A Prospective Cohort Study on Overweight, Smoking, Alcohol Consumption, and Risk of Barrett's Esophagus

Steevens, Jessie; Schouten, Leo J.; Driessen, Ann; Huysentruyt, Clément J.R.; Keulemans, Yolande C.A.; Goldbohm, R. Alexandra; Brandt, Piet A. van den

doi:10.1158/1055-9965.epi-10-0636

Cited by 61 publications

(53 citation statements)

References 42 publications

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“…For example, over 70% of the Japanese subjects had a BMI <25.0 [29], while in contrast over 70% of individuals in the USA had a BMI >25.0 [48]. Regarding the relationship between BMI and BE formation, we found a positive association between the two factors, consistent with previous reports from Western countries [38,39,40,41,49]. Further, we identified even slightly overweight subjects (BMI 23.0-24.9) as having an independent risk factor for BE, in contrast with previous reports from Western countries in which a BMI >25.0 or >30.0 has been associated with BE [38,39,40,41,49].…”

Section: Discussionsupporting

confidence: 89%

“…We found increased BMI to be an independent risk factor for BE in addition to the well-recognized GERD-related risk factors such as heartburn and hiatal hernia. Although BMI >25 or >30 have sometimes been identified as an increased risk factor for BE in Caucasian populations [38,39,40,41], this study clarified that even slightly overweight Japanese subjects with a BMI of 23.0-24.9 have a significantly increased risk of BE, suggesting that the Japanese are predisposed to BE at lower BMI compared to Caucasian populations. In addition, there seemed to be gender-related differences in the association between BMI and BE, i.e.…”

Section: Discussionmentioning

confidence: 62%

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Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Shinkai

Iijima²,

Koike³

et al. 2014

Digestion

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Background: We investigated the association between long-segment Barrett's esophagus and obesity in the Japanese population in a multicenter case-control trial. Methods: One hundred thirteen patients with endoscopically detected Barrett's esophagus with a length of more than 2 cm and the same number of sex- and age-matched controls were prospectively enrolled. Barrett's esophagus was diagnosed based on the Prague C and M criteria. The body mass index (BMI) of the subjects was categorized into the following groups: normal, BMI <22.9; overweight, BMI 23.0-24.9, and obese, BMI >25.0. To determine the association between BMI and the risk of Barrett's esophagus, multivariate logistic regression analyses were performed. Results: The basically adjusted regression model adjusted for smoking and alcohol consumption revealed that overweight and obesity were significantly associated with an elevated risk of Barrett's esophagus (OR 2.4, 95% CI 1.2-4.7, and OR 2.5, 95% CI 1.3-4.6, respectively). The intensity of the association was not attenuated even after adjustment for gastroesophageal reflux disease-related parameters. Conclusions: An increased BMI was associated with an increased risk for Barrett's esophagus through a gastroesophageal reflux-independent mechanism in the Japanese population. Further, unlike in Caucasian populations, being even slightly overweight with a BMI of 23.0-24.9 was an independent risk factor in the Japanese population.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 62%

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Shinkai

Iijima²,

Koike³

et al. 2014

Digestion

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“…However, the association between alcohol intake and esophageal adenocarcinoma (EAC) is attenuated. The two cohort studies by Steevens et al (17,30) revealed that alcohol consumption did not promote the risk of developing EAC or Barrett's esophagus (precancerous lesions of EAC). Other analyses reached similar conclusions (29,31,32).…”

Section: Subtypes Of Esophageal Cancermentioning

confidence: 98%

Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer

2016

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Abstract. Esophageal cancer is the eighth most common type of cancer in the world, and the sixth most common cause of mortality from cancer. Alcohol consumption is the major risk factor for esophageal cancer, due to the worldwide prevalence and high carcinogenicity of the ethanol metabolite. In epidemiological studies, the efficiency of alcohol intake to enhance the risk of esophageal cancer is altered by daily ethanol consumption, type of alcoholic beverages ingested, time since quitting drinking, age of drinking initiation, differences in population and subtypes of esophageal cancer. Corresponding factors, including gene polymorphisms, tobacco smoking, oral microorganisms and folate deficiency, reveal a synergistic effect in concurrent alcohol users that may lead to an increased risk of developing esophageal cancer. Consequently, esophageal cancer prevention involves multiple aspects, including quitting drinking and smoking, maintaining an adequate oral health and ingesting adequate quantities of folate, particularly in genetically high-risk populations.

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“…Pre-existing diabetes may increase the risk of mortality by as much as 40% in people with cancer [43]. While gastroesophageal reflux and high body mass index are known as well established risk factors for esophageal cancers [44][45][46], it has also reported that diabetes was associated with substantial and a significant increased risk of esophageal adenocarcinoma [47][48][49][50][51].…”

Section: Ampk Pathway As a Target For Esophagus Cancer Treatmentmentioning

confidence: 99%

Inhibition of tumor energy pathways for targeted esophagus cancer therapy

et al. 2015

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A Prospective Cohort Study on Overweight, Smoking, Alcohol Consumption, and Risk of Barrett's Esophagus

Cited by 61 publications

References 42 publications

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer

Inhibition of tumor energy pathways for targeted esophagus cancer therapy

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