A Prospective Analysis of Drug  Interactions in Patients of Intensive  Cardiac Care Unit

Jain, Shipra; Jain, Pooja; Sharma, Kopal; Saraswat, Pushpendra

doi:10.7860/jcdr/2017/23638.9403

Cited by 25 publications

(33 citation statements)

References 20 publications

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“…identified age and polypharmacy having a positive correlation with the drug interaction. [18] Polypharmacy, length of stay, and concurrent illness are the most crucial determinants of pDDIs. [15] Predictors of pDDIs.…”

Section: Discussionmentioning

confidence: 99%

Assessment of potential drug–Drug interactions in hospitalized cardiac patients of a secondary care hospital in the United Arab Emirates

Sridhar

Gupta²

2019

J Res Pharm Pract

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Objective: To identify the types, severity, and documentation grades of potential drug–drug interactions (pDDIs) and to identify the predictors of pDDIs among hospitalized cardiac patients. Methods: This was a cross-sectional study. All the patients who were admitted for >24 h in a cardiology ward of a general hospital of the United Arab Emirates and prescribed with cardiac medications were included. The occurrence of any pDDI between cardiac medications and other coprescribed medications was identified using Micromedex database 2.0 ® and graded and documented based on the severity and documentation. Findings: A total of 842 pDDIs were identified in 155 patients. The overall relevant frequency for the occurrence of pDDIs was found to be 87.74%. A total of 79 pairs of pDDIs were identified. Among identified pDDIs, 41.33% and 56.65% were major and moderate severity type, respectively, whereas 12.32% were excellent and 36.81% were good documentation grade. The majority of pDDIs were between aspirin-bisoprolol (11.64%). Patients taking more than seven drugs (odds ratio [OR] = 9.90; 95% confidence interval [CI]: 2.28–42.99), polypharmacy (OR = 3.86; 95% CI: 0.93–16.08), and number of medical conditions (OR 0.25; 95% CI: 0.09–0.68) were significant predictors of pDDIs. Conclusion: The study fosters the importance of regular and close monitoring for pDDIs among cardiac patients. Thus, multicenter interventional studies are required to determine the exact nature and types of pDDIs in the local population.

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Section: Discussionmentioning

confidence: 99%

Assessment of potential drug–Drug interactions in hospitalized cardiac patients of a secondary care hospital in the United Arab Emirates

Sridhar

Gupta²

2019

J Res Pharm Pract

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“…These interactions are preventable by substituting the participate drug (thiazide by furosemide) or substituting metformin by sulfonylureas in the case of spironolactone drug interactions with metformin. [ 42 43 ]…”

Section: Discussionmentioning

confidence: 99%

Drug-drug interaction-related uncontrolled glycemia

et al. 2017

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“…Највећи број истраживања о интеракцијама лекова спроведен је код болесника који су били на болничком лечењу, јер су истраживачи тада имали потпуни увид у целокупну примењену терапију. Тако је у истраживању које је спроведено у терцијарној болници у Раџастану, Индија, на 500 кардиолошких пацијената, применом овог Интернет програма уочено 2.849 интеракција, од којих су значајне 71,29%, минорне 25,45%, док су озбиљне интеракције уочене у 3,26% парова лекова 12 .…”

Section: дискусијаunclassified

Drug Interaction Checker in Emergency exam room, Belgrade

Živanović¹,

Petrov-Kiurski²

2018

Opšta medicina

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A Prospective Analysis of Drug Interactions in Patients of Intensive Cardiac Care Unit

Abstract: The risk of pDDI was more commonly observed in elderly male patients particularly with antiplatelet drugs like low dose aspirin and clopidogrel.

Cited by 25 publications

References 20 publications

Assessment of potential drug–Drug interactions in hospitalized cardiac patients of a secondary care hospital in the United Arab Emirates

Assessment of potential drug–Drug interactions in hospitalized cardiac patients of a secondary care hospital in the United Arab Emirates

Drug-drug interaction-related uncontrolled glycemia

Drug Interaction Checker in Emergency exam room, Belgrade

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