A promising of alloying modified beta-type Titanium-Niobium implant for biomedical applications: Microstructural characteristics, in vitro biocompatibility and antibacterial performance

Ou, Keng-Liang; Weng, Chao Chia; Lin, Yu-Chen; Huang, Mao-Suan

doi:10.1016/j.jallcom.2016.12.120

Cited by 50 publications

(26 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies had shown that MAO treatment on Ti surfaces enhanced its biological response. Alves et al performed PEO on commercial pure Ti and studied the biological properties of Ca‐and P‐enriched layers assessed for osteoblastic cell viability/proliferation ability.…”

Section: Introductionmentioning

confidence: 99%

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

et al. 2018

View full text Add to dashboard Cite

Highly porous Ti implant materials are being used in order to overcome the stress shielding effect on orthopedic implants. However, the lack of bioactivity on Ti surfaces is still a major concern regarding the osseointegration process. It is known that the rapid recruitment of osteoblasts in bone defects is an essential prerequisite for efficient bone repair. Conventionally, osteoblast recruitment to bone defects and subsequent bone repair has been achieved using growth factors. Thus, in this study highly porous Ti samples were processed by powder metallurgy using space holder technique followed by the bio-functionalization through microarc oxidation using a Ca- and P-rich electrolyte. The biological response in terms of early cell response, namely, adhesion, spreading, viability, and proliferation of the novel biofunctionalized highly porous Ti was carried out with NIH/3T3 fibroblasts and MC3T3-E1 preosteoblasts in terms of viability, adhesion, proliferation, and alkaline phosphatase activity. Results showed that bio-functionalization did not affect the cell viability. However, bio-functionalized highly porous Ti (22% porosity) enhanced the cell proliferation and activity. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.

show abstract

Section: Introductionmentioning

confidence: 99%

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In vitro cell culturing is the main method used to evaluate the biocompatibility of implant materials. In vitro biocompatibility test, which is simple and repeatable, has been the preferred method to assess the biocompatibility of materials [ 27 , 28 ]. Direct contact method provides the advantage of high susceptibility to toxicity testing for the evaluation of the biocompatibility of PDLLA-1 and PDLLA-2.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of salen-Ti(IV) complex and application in the controllable polymerization of D, L-lactide

Yang

Zheng

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

Poly(lactic acid) has been extensively investigated in the biomedical field because of its good biocompatibility and biodegradability. As an important method of poly(lactic acid) synthesis, metal complex-catalyzed ring-opening polymerization (ROP) of lactide can achieve a controllable lactide polymerization through the selection of appropriate ligands and metals. In this study, a novel metal (LTi–O)2 complex was synthesized and structurally characterized. (LTi–O)2 showed a relatively high catalytic activity and controllability of Poly(D, L-lactide) (PDLLA) molecular weights (polydispersity index of 1.02–1.22) in the ROP of D,L-lactide. The kinetic equation of D,L-LA ROP catalyzed by (LTi–O)2 could be expressed as–d[M]/dt = k[M]2[(LTi–O)2]1, and the reaction activation energy was 95.67 kJ·mol−1. Physical/chemical properties and biocompatibility evaluation results showed that PDLLA obtained through the (LTi–O)2-catalyzed ROP of D,L- lactide exhibited a good degradation performance and excellent biocompatibility.

show abstract

“…Moreover, a comparison of Ag particles found that the antibacterial effects were enhanced by decreasing the size of the Ag particles [46,55]. Ou [56] reported that the strong antibacterial agents of Ag nanoparticles or Ag + ions could be released from Ag-rich compounds precipitated in the matrix of the Ag-bearing Ti-27.5Nb alloys into the surrounding solution. Therefore, Ag nanoparticles or Ag + ions can destroy the cell walls or cell membranes of bacteria in order to inhibit their growth [57].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Properties and Corrosion Resistance of the Newly Developed Biomaterial, Ti–12Nb–1Ag Alloy

Chao

Chiu

et al. 2017

Metals

View full text Add to dashboard Cite

Currently, the development of biomaterials has focused on having a low Young's modulus, biocompatibility, corrosion resistance, and antibacterial properties. Ti-Nb alloys have higher research value due to their excellent corrosion resistance and low Young's modulus. In recent years, the antibacterial properties of materials have been enhanced by the addition of Ag and Cu. Therefore, the corrosion resistance and antibacterial properties of the Ti-12Nb-1Ag alloy formulated in the current study were investigated and compared to those of commonly used Ti alloys, G2 pure Ti (ASTM B348 CP Grade 2), and Ti-6Al-4V, via electrochemical and E. coli antibacterial tests. Meanwhile, we also carried out a microstructural analysis to investigate the composition of the alloy. The results were as follows: (1) The electrochemical test demonstrated that Ti-12Nb-1Ag had a higher corrosion resistance than Ti-6Al-4V, which is similar to the properties of pure Ti. (2) The E. coli antibacterial test demonstrated that the sterilization rate of Ti-12Nb-1Ag was higher than that of the Ti-6Al-4V alloy and pure Ti. (3) The microstructural analysis revealed that Ti-12Nb-1Ag had an acicular martensite structure, with nano-Ag precipitates observed. Based on the results of the E. coli antibacterial test and the principles of sterilization of nano-precipitates and Ag, we inferred that the nano-Ag precipitates of Ti-12Nb-1Ag enhanced the antibacterial properties of the newly developed biomaterial, which is, namely, the Ti-12Nb-1Ag alloy.

show abstract

A promising of alloying modified beta-type Titanium-Niobium implant for biomedical applications: Microstructural characteristics, in vitro biocompatibility and antibacterial performance

Cited by 50 publications

References 41 publications

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

Synthesis and characterization of salen-Ti(IV) complex and application in the controllable polymerization of D, L-lactide

Antibacterial Properties and Corrosion Resistance of the Newly Developed Biomaterial, Ti–12Nb–1Ag Alloy

Contact Info

Product

Resources

About