A Prognostic Model Based on Clinicopathological Features and Inflammation- and Nutrition-Related Indicators Predicts Overall Survival in Surgical Patients With Tongue Squamous Cell Carcinoma

Abstract

Objectives: It is reported that inflammation- and nutrition-related indicators have a prognostic impact on multiple cancers. Here we aimed to identify a prognostic nomogram model for prediction of overall survival (OS) in surgical patients with tongue squamous cell carcinoma (TSCC). Methods: The retrospective data of 172 TSCC patients were charted from the Cancer Hospital of Shantou University Medical College between 2008 and 2019. A Cox regression analysis was performed to determine prognostic factors to establish a nomogram and predict OS. The predictive accuracy of the model was analyzed by the calibration curves and the concordance index (C-index). The difference of OS was analyzed by Kaplan–Meier survival analysis. Results: Multivariate analysis showed age, tumor node metastasis (TNM) stage, red blood cell, platelets, and platelet-to-lymphocyte ratio were independent prognostic factors for OS, which were used to build the prognostic nomogram model. The C-index of the model for OS was 0.794 (95% CI = 0.729-0.860), which was higher than that of TNM stage 0.685 (95% CI = 0.605-0.765). In addition, decision curve analysis also showed the nomogram model had improved predictive accuracy and discriminatory performance for OS, compared to the TNM stage. According to the prognostic model risk score, patients in the high-risk subgroup had a lower 5-year OS rate than that in a low-risk subgroup (23% vs 49%, P < .0001). Conclusions: The nomogram model based on clinicopathological features inflammation- and nutrition-related indicators represents a promising tool that might complement the TNM stage in the prognosis of TSCC.

Prognostic and clinicopathological role of pretreatment systemic immune-inflammation index in patients with oral squamous cell carcinoma: a meta-analysis

“…All included studies were retrospective in nature, published in the English language and had publication years ranging from 2018 to 2022. Four studies were carried out in China ( 18 , 20 , 22 , 23 ), two in Taiwan ( 21 , 25 ), and one each in Turkey ( 19 ), Korea ( 24 ), Japan ( 26 ), Spain ( 27 ), and Malaysia ( 28 ). Sample sizes ranged from 58-993 (median, 269).…”

“…Ten articles described single center studies ( 19 – 28 ) and one was a multicenter study ( 18 ). Seven studies recruited patients with OSCC ( 18 , 22 , 24 – 28 ), two recruited oral cavity cancer cases ( 19 , 21 ), and two involved tongue cancer cases ( 20 , 23 ). Ten articles described studies involving patients with TNM stage I-IV ( 18 – 21 , 23 – 28 ), whereas one study only included stage III-IV patients ( 22 ).…”

“…Seven studies recruited patients with OSCC ( 18 , 22 , 24 – 28 ), two recruited oral cavity cancer cases ( 19 , 21 ), and two involved tongue cancer cases ( 20 , 23 ). Ten articles described studies involving patients with TNM stage I-IV ( 18 – 21 , 23 – 28 ), whereas one study only included stage III-IV patients ( 22 ). Seven studies treated patients with surgery ( 18 , 20 , 22 – 25 , 27 ), three studies used surgery and concurrent chemoradiotherapy (CCRT) ( 21 , 26 , 28 ), and one study only applied radiotherapy (RT) ( 19 ).…”

“…The threshold SII ranged from 204-1,137 (median, 569) in all 11 studies. Seven articles described the threshold through receiver operating characteristic curve ( 19 , 21 , 22 , 24 , 25 , 27 , 28 ), three studies applied the X-tile software ( 18 , 20 , 23 ), whereas another one was determined using previous literature ( 26 ). Nine articles reported a prognostic effect of SII for OS ( 18 – 23 , 25 – 27 ) and nine mentioned a relationship between SII and DFS ( 18 – 20 , 22 , 24 – 28 ) in OSCC.…”

“…For example, a higher SII was reported as a distinct prognostic indicator of OSCC in certain articles ( 19 , 26 , 28 ). In contrast, some researchers indicated the absence of any obvious association of SII with survival outcomes in OSCC ( 23 – 25 ). Consequently, to identify the precise impact of SII on predicting OSCC prognosis, this work carried out comprehensive literature retrieval for meta-analysis.…”