A prognostic index for thyroid carcinoma. A study of the E.O.R.T.C. thyroid cancer cooperative group

Byar, David P.; Green, Sylvan S.B.; Dor, Pierre; Williams, E. D.; Colon, J; Gilse, Henriette H.A. van; Mayer, M; Sylvester, Richard; Glabbeke, M. van

doi:10.1016/0014-2964(79)90291-3

Cited by 514 publications

(293 citation statements)

References 6 publications

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“…Some investigators have reported that the age of the patient is an important prognostic factor in papillary and follicular carcinomas (Crile and Hazard, 1953;Cady et al, 1979), whereas others (Franssila, 1975;Byar et al, 1979;Hay et al, 1993) have great emphasis on age, sex and tumour status in the scoring system. Shi and Farid (1993) reported a negative correlation between expression of TSH-R mRNA and tumour stage in most patients.…”

Section: Resultsmentioning

confidence: 99%

“…The clinical stages of the papillary carcinomas and follicular carcinomas were determined according to the UICC classification (Hermanek and Sobin, 1990). The total score of the patients was decided according to the EORTC prognostic index system (Byar et al, 1979). The total score of EORTC is calculated by summing age + 12 (if male), +10 (if medullary or if the principal cell type is of follicular, less differentiated type and provided that the associated cell type is not anaplastic), +45 (if anaplastic cell type), +10 (if the T-category is T3), +15 (if one distant metastasis) or +15 (if multiple distant metastases).…”

Section: Materials and Methods Materialsmentioning

confidence: 99%

“…With these two scoring systems, the higher the score, the poorer the prognosis (Byar et al, 1979;Hay et al, 1993). According to Hay et al (1993), the survival rates for patients with MACIS scores of < 6, 6-6.99, 7-7.99, and 8+ were 99%, 89%, 56%, and 24% respectively.…”

Section: +1 (If Incompletely Resected) +1 (If Locally Invasive) or +mentioning

confidence: 99%

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Relationship between prognostic score and thyrotropin receptor (TSH-R) in papillary thyroid carcinoma: immunohistochemical detection of TSH-R

Tanaka

Inoue²,

Miki³

et al. 1997

Br J Cancer

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Summary We have demonstrated the expression of thyrotropin receptor (TSH-R) in thyroid neoplasms (13 adenomas, 21 papillary carcinomas, two follicular carcinomas) and adjacent normal thyroid using the monoclonal antibody against human TSH-R and have also demonstrated a relationship between prognostic scores and the expression of TSH-R. Among the adenomas, eight showed an intensity similar to that of normal thyroid and five showed a higher intensity than normal. Two tumours exhibited heterogeneous distribution of TSH-R. Among the papillary carcinomas, seven showed similar intensity to normal tissue and four showed higher intensity and ten showed weaker intensity. Eight tumours showed heterogeneous distribution of the stain. Among the follicular carcinomas, one showed similar intensity to normal tissue and the other exhibited weaker intensity. Both cases showed homogeneous distribution of TSH-R. The adenomas never showed a weaker intensity than normal thyroid, but various intensities of TSH-R occurred in differentiated carcinomas. There was no significant relationship between the clinical data and the signal intensity in the adenomas. Among the papillary carcinomas, however, the group with weaker intensity had significantly poorer prognostic scores than the other two groups. Thus, we assume that low TSH-R may be expressed by the clinically high-rsk group of patients with papillary thyroid carcinoma.

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Section: Resultsmentioning

confidence: 99%

Section: Materials and Methods Materialsmentioning

confidence: 99%

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Relationship between prognostic score and thyrotropin receptor (TSH-R) in papillary thyroid carcinoma: immunohistochemical detection of TSH-R

Tanaka

Inoue²,

Miki³

et al. 1997

Br J Cancer

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“…In thyroid cancer, the AJCC/UICC Stage does not take account of several additional independent prognostic variables and may risk misclassification of some patients. Numerous other schemes have been developed in an effort to achieve more accurate risk factor stratification, including CAEORTC, AGES, AMES, U of C, MACIS, OSU, MSKCC, and NTCTCS systems (61, 62,68,98,[122][123][124][125]. These schemes take into account a number of factors identified as prognostic for outcome in multivariate analysis of retrospective studies, with the most predictive factors generally being regarded as the presence of distant metastases, the age of the patient, and the extent of the tumor.…”

Section: What Is the Role Of Postoperative Staging Systems And Which mentioning

confidence: 99%

Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce

Cooper

Doherty

Haugen

et al. 2006

Thyroid

1,915

938

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“…The incidence of PTMC has increased dramatically and it presents overall excellent prognosis that the overall 10-year survival rate associated with this malignancy is >90% (Wang et al, 2014). However, many current guidelines and recommendations regarding the optimal treatment strategy for PTMC remain controversial (Byar et al, 1979;Udelsman et al, 1996). The reason is that we could not accurately predict the aggressiveness of tumors before the operation.…”

Section: Introductionmentioning

confidence: 99%

Could Tumor Size Be A Predictor for Papillary Thyroid Microcarcinoma: a Retrospective Cohort Study

Wang¹,

Wu²,

Chen³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Central lymph node metastasis(CLNM) is common in papillary thyroid microcarcinoma (PTMC). The aim of this study was to define the pathohistologic risk grading based on surgical outcomes. Materials and Methods: Statistical analysis was performed to figure out the optimal cut-off values of size in preoperative ultrasound images for defining the risk of CLNM in papillary thyroid microcarcinoma. Receiver operating characteristic curves (ROC) studies were carried out to determine the cutoff value(s) for the predictor(s). All the patients were divided into two groups according to the above size and the clinic-pathological and immunohistochemical parameters were compared to determine the significance of findings. Results: The optimal cut-off value of tumor size to predict the risk of CLNM in papillary thyroid microcarcinoma was 0.575 cm (area under the curve 0.721) according to the ROC curves. Significant differences were observed on the multifocality, extrathyroidal extension and central lymph node metastasis between two groups which were divided according to the tumor size by the cutoff values. Patients in two groups showed different positive rate and intensity of Ki67. Conclusions: The size of PTMC in ultrasound images are helpful to predict the aggressiveness of the tumors, it could be an easy predictor for PTMC prognosis and assist us to choose treatment.

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A prognostic index for thyroid carcinoma. A study of the E.O.R.T.C. thyroid cancer cooperative group

Cited by 514 publications

References 6 publications

Relationship between prognostic score and thyrotropin receptor (TSH-R) in papillary thyroid carcinoma: immunohistochemical detection of TSH-R

Relationship between prognostic score and thyrotropin receptor (TSH-R) in papillary thyroid carcinoma: immunohistochemical detection of TSH-R

Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce

Could Tumor Size Be A Predictor for Papillary Thyroid Microcarcinoma: a Retrospective Cohort Study

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