A product portfolio approach in the pharmaceutical industry

Rotstein, G.E.; Papageorgiou, Lazaros G.; Shah, Nilay; Murphy, D. C.; Mustafa, R.

doi:10.1016/s0098-1354(99)80217-8

Cited by 36 publications

(9 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This hierarchical solution approach is able to find an effective solution with up to seven products using a reasonable amount of time. In all of their examples, they find this approach outperforms the cut-off procedure proposed in Rotstein [24].…”

Section: Figure 1 Tree Representation Of Clinical Trails Outcomesmentioning

confidence: 95%

See 1 more Smart Citation

Analytical models for biopharmaceutical operations and supply chain management: a survey of research literature

Kaminsky

Wang²

2015

Pharmaceutical Bioprocessing

View full text Add to dashboard Cite

While sophisticated analytical tools and models for operations and supply chain management are increasingly used in many industries, the biopharmaceutical industry lags many others in terms of applying these approaches. We survey the (relatively small number of) papers that explore the use of analytical models to address various strategic, tactical and operational issues in biopharmaceutical operations and supply chain management, discuss gaps in current knowledge, and identify opportunities to further extend the state-of-the art in this area.

show abstract

Section: Figure 1 Tree Representation Of Clinical Trails Outcomesmentioning

confidence: 95%

“…Rotstein et al [24] first develop a stochastic model for simultaneous product selection and capacity planning that incorporates binary clinical trial uncertainty (i.e., success/failure). They develop a heuristic cut-off procedure to address larger size instances.…”

Section: Strategic Decisionsmentioning

confidence: 99%

Analytical models for biopharmaceutical operations and supply chain management: a survey of research literature

Kaminsky

Wang²

2015

Pharmaceutical Bioprocessing

View full text Add to dashboard Cite

show abstract

“…One of the first studies of network design for the pharmaceutical industry was developed by Rotstein et al [20]. In this paper, the authors develop an optimization model for product development, introduction strategy, capacity strategy, and investment strategy.…”

Section: Supply Chain Networkmentioning

confidence: 99%

A Structured Review of Quantitative Models of the Pharmaceutical Supply Chain

Franco

Alfonso-Lizarazo

2017

Complexity

View full text Add to dashboard Cite

The aim of this review is to identify and provide a structured overview of quantitative models in the pharmaceutical supply chain, a subject not exhaustively studied in the previous reviews on healthcare logistics related mostly to quantitative models in healthcare or logistics studies in hospitals. The models are classified into three categories of classification: network design, inventory models, and optimization of a pharmaceutical supply chain. A taxonomy for each category is shown describing the principal features of each echelon included in the review; this taxonomy allows the readers to identify easily a paper based on the actors of the pharmaceutical supply chain. The search process included research articles published in the databases between 1984 and November 2016. In total 46 studies were included. In the review process we found that in the three fields the most common source of uncertainty used is the demand in the 56% of the cases. Within the review process we can conclude that most of the articles in the literature are focused on the optimization of the pharmaceutical supply chain and inventory models but the field on supply chain network design is not deeply studied.

show abstract

“…Hence, diverse fields of application are possible in a pharmaceutical context. These applications could support decision making for pipeline management [12][13][14] and optimize supply chain management [15][16][17]. Simulations of production processes are also of interest.…”

Section: Introductionmentioning

confidence: 99%

Analysis and Optimization of Two Film-Coated Tablet Production Processes by Computer Simulation: A Case Study

Hering

Schäuble²,

Buck³

et al. 2020

Processes

View full text Add to dashboard Cite

Increasing regulatory demands are forcing the pharmaceutical industry to invest its available resources carefully. This is especially challenging for small- and middle-sized companies. Computer simulation software like FlexSim allows one to explore variations in production processes without the need to interrupt the running process. Here, we applied a discrete-event simulation to two approved film-coated tablet production processes. The simulations were performed with FlexSim (FlexSim Deutschland—Ingenieurbüro für Simulationsdienstleistung Ralf Gruber, Kirchlengern, Germany). Process visualization was done using Cmap Tools (Florida Institute for Human and Machine Cognition, Pensacola, FL, USA), and statistical analysis used MiniTab® (Minitab GmbH, Munich, Germany). The most critical elements identified during model building were the model logic, operating schedule, and processing times. These factors were graphically and statistically verified. To optimize the utilization of employees, three different shift systems were simulated, thereby revealing the advantages of two-shift and one-and-a-half-shift systems compared to a one-shift system. Without the need to interrupt any currently running production processes, we found that changing the shift system could save 50–53% of the campaign duration and 9–14% of the labor costs. In summary, we demonstrated that FlexSim, which is mainly used in logistics, can also be advantageously implemented for modeling and optimizing pharmaceutical production processes.

show abstract

A product portfolio approach in the pharmaceutical industry

Cited by 36 publications

References 5 publications

Analytical models for biopharmaceutical operations and supply chain management: a survey of research literature

Analytical models for biopharmaceutical operations and supply chain management: a survey of research literature

A Structured Review of Quantitative Models of the Pharmaceutical Supply Chain

Analysis and Optimization of Two Film-Coated Tablet Production Processes by Computer Simulation: A Case Study

Contact Info

Product

Resources

About