A probable case of rotavirus exanthem

Ruzicka, T.

doi:10.1001/archderm.121.2.253

Cited by 8 publications

(9 citation statements)

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“…Rotaviral infection is generally thought to be localized to the epithelial cells lining the small intestine. However, case reports suggest that rotavirus may cause infection and illness outside the intestine, including hepatitis and nephritis [3], pneumonia [4], exanthema [5], disseminated intravascular coagulation [6], haemophagocytic lymphohistiocytosis [7], and neurological complications such as encephalitis [8], encephalopathy [7], cerebellitis [9], or convulsions or seizures [10,11]. Reports of attempts to find rotavirus RNA or proteins at extraintestinal sites include detection of RNA in cerebral spinal fluid [12,13], central nervous system [14], heart [14,15], blood [16], and endothelial cells [14,17], while rotavirus nonstructural proteins were detected in liver and kidney sections [3].…”

Section: Introductionmentioning

confidence: 99%

Rotavirus Antigenemia in Children Is Associated with Viremia

Matson²,

et al. 2007

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BackgroundAntigenemia is commonly detected in rotavirus-infected children. Although rotavirus RNA has been detected in serum, definitive proof of rotavirus viremia has not been shown. We aimed to analyze a defined patient population to determine if infectious virus could be detected in sera from children with rotavirus antigenemia.Methods and FindingsSerum samples obtained upon hospitalization from children with gastroenteritis (57 stool rotavirus-positive and 41 rotavirus-negative), children with diagnosed bronchiolitis of known (n = 58) or unknown (n = 17) viral etiology, children with noninfectious, nonchronic conditions (n = 17), and healthy adults (n = 28) were tested for rotavirus antigen by enzyme immunoassay (EIA). Results of serum antigen testing were assessed for association with clinical and immunological attributes of the children. Rotavirus antigenemia was detected in 90% (51/57) of children with rotavirus-positive stools, in 89% (8/9) of children without diarrhea but with rotavirus-positive stools, in 12% (2/17) of children with bronchiolitis of unknown etiology without gastroenteritis, and in 12% (5/41) of children with gastroenteritis but with rotavirus-negative stools. Antigenemia was not detected in sera from children with noninfectious nonchronic conditions, children with bronchiolitis of known etiology and no gastroenteritis, or healthy adults. Neither age nor timing of serum collection within eight days after onset of gastroenteritis significantly affected levels of antigenemia, and there was no correlation between antigenemia and viral genotype. However, there was a negative correlation between serum rotavirus antigen and acute rotavirus-specific serum IgA (r = −0.44, p = 0.025) and IgG (r = −0.40, p = 0.01) titers. We examined 11 antigen-positive and nine antigen-negative sera for infectious virus after three blind serial passages in HT-29 cells using immunofluorescence staining for rotavirus structural and nonstructural proteins. Infectious virus was detected in 11/11 (100%) sera from serum antigen-positive children and in two out of nine (22%) sera samples from antigen-negative children (p = 0.002).ConclusionsMost children infected with rotavirus are viremic. The presence of viremia is directly related to the detection of antigenemia and is independent of the presence of diarrhea. Antigenemia load is inversely related to the titer of antirotavirus antibody in the serum. The finding of infectious rotavirus in the blood suggests extraintestinal involvement in rotavirus pathogenesis; however, the impact of rotavirus viremia on clinical manifestations of infection is unknown.

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Section: Introductionmentioning

confidence: 99%

Rotavirus Antigenemia in Children Is Associated with Viremia

Matson²,

et al. 2007

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“…15 Therefore, systemic manifestations including cutaneous disorders, although rare, may be associated with rotavirus infection. 16 Ruzicka et al, 12 reported the first case of a patient with signs of hepatitis and generalized maculo-papular exanthema which developed one week after his two sons had suffered from rotavirus gastroenteritis. Rotavirus antibody at titers of 1:256 and 1:512 were identified from the patient's serum.…”

Section: Discussionmentioning

confidence: 99%

“…In developing countries, rotavirus-related diarrhea and vomiting, together, are the major causes of severe dehydration and eventual death in children. [1][2][3] Apart from gastroenteritis, rotavirus has also been implicated with several systemic disorders such as elevated transaminase, 4 convulsion, 5,6 encephalitis, 7 pneumonia, 8 disseminated intravascular coagulation, 9 hemophagocytic lymphohistiocytosis, 10 nephritis in children with immunodeficiency 11 and also with several cutaneous disorders such as generalized maculopapular exanthema, 12 infantile acute hemorrhagic edema 13 and Gianotti-Crosti syndrome.…”

Section: Introductionmentioning

confidence: 99%

Macular exanthema in a child with rotavirus gastroenteritis: A case report

2014

Arch Argent Pediat

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Apart from gastroenteritis, rotavirus has been rarely implicated with some cutaneous disorders such as generalized maculopapular exanthema, infantile acute hemorrhagic edema and Gianotti-Crosti syndrome. We report a 30-month old toddler boy who developed erythematous macular skin eruptions during the course of rotavirus gastroenteritis. To our knowledge, this is the first case in the literature reporting rotavirusrelated macular erythematous lesions in a pediatric patient. We therefore would like to share our experience, to keep rotavirus infection in the differential diagnosis of children with gastroenteritis and erythematous eruption.

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“…15 En consecuencia, si bien son poco frecuentes, las manifestaciones sistémicas, incluidos los trastornos cutáneos, pueden estar asociadas a infección por rotavirus. 16 Ruzicka et al, 12 informaron el primer caso de un paciente con signos de hepatitis y exantema maculopapular generalizado una semana después de que sus dos hijos presentaran gastroenteritis por rotavirus. En el suero del paciente se identificaron anticuerpos de rotavirus con títulos de 1:256 y 1:512.…”

Section: Discussionunclassified

“…14 Sin embargo, raramente se ha informado exantema asociado a rotavirus. 12 Comunicamos el caso de un niño de 30 meses de edad que presentó erupciones cutáneas maculares eritematosas mientras cursaba una gastroenteritis por rotavirus.…”

Section: Macular Exanthema In a Child With Rotavirus Gastroenteritis:unclassified

Exantema macular en un niño con gastroenteritis por rotavirus. Informe de caso

et al. 2014

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Apart from gastroenteritis, rotavirus has been rarely implicated with some cutaneous disorders such as generalized maculo-papular exanthema, infantile acute hemorrhagic edema and Gianotti-Crosti syndrome. We report a 30-month old toddler boy who developed erythematous macular skin eruptions during the course of rotavirus gastroenteritis. To our knowledge, this is the first case in the literature reporting rotavirus-related macular erythematous lesions in a pediatric patient. We therefore would like to share our experience, to keep ro-tavirus infection in the differential diagnosis of children with gastroenteritis and erythematous eruption.

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A probable case of rotavirus exanthem

Cited by 8 publications

References 0 publications

Rotavirus Antigenemia in Children Is Associated with Viremia

Rotavirus Antigenemia in Children Is Associated with Viremia

Macular exanthema in a child with rotavirus gastroenteritis: A case report

Exantema macular en un niño con gastroenteritis por rotavirus. Informe de caso

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