A preliminary study of the clinical significance of folate receptor- positive circulating tumor cell in the management of hepatobiliary- pancreatic cancers

He, Yonggang; Gao, Ming-fa; Tang, Yichen; Li, Yuming; Yu, Kaihuan; Li, Jing; Huang, Xiaobing

doi:10.21037/tcr-20-2192

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…28,29,[47][48][49] A few studies revealed that pre-and post-operative FR + CTC levels are strong risk factors of recurrence and prognosis and may be used for clinical decision making. [50][51][52][53] In stage IV NSCLC patients receiving first-line chemotherapy or targeted therapy, FR + CTC levels before and after treatment and the dynamic changes of FR + CTC during treatment were associated with progression-free survival. Similar results were found for SCLC patients with chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, FR has been adopted as a target for CTC enumeration and its applications in clinical diagnosis and prognosis in lung cancer have received much attention 28,29,47–49 . A few studies revealed that pre‐ and post‐operative FR + CTC levels are strong risk factors of recurrence and prognosis and may be used for clinical decision making 50–53 . In stage IV NSCLC patients receiving first‐line chemotherapy or targeted therapy, FR + CTC levels before and after treatment and the dynamic changes of FR + CTC during treatment were associated with progression‐free survival.…”

Section: Discussionmentioning

confidence: 99%

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A combined diagnostic model based on circulating tumor cell in patients with solitary pulmonary nodules

Wang

Xiang

Che

et al. 2023

The Journal of Gene Medicine

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BackgroundAlthough many prediction models in diagnosis of solitary pulmonary nodules (SPNs) have been developed, few are widely used in clinical practice. It is therefore imperative to identify novel biomarkers and prediction models supporting early diagnosis of SPNs. This study combined folate receptor‐positive circulating tumor cells (FR+CTC) with serum tumor biomarkers, patient demographics and clinical characteristics to develop a prediction model.MethodsA total of 898 patients with a solitary pulmonary nodule who received FR+CTC detection were randomly assigned to a training set and a validation set in a 2:1 ratio. Multivariate logistic regression was used to establish a diagnostic model to differentiate malignant and benign nodules. The receiver operating curve (ROC) and the area under the curve (AUC) were calculated to assess the diagnostic efficiency of the model.ResultsThe positive rate of FR+CTC between patients with non‐small cell lung cancer (NSCLC) and benign lung disease was significantly different in both the training and the validation dataset (p < 0.001). The FR+CTC level was significantly higher in the NSCLC group compared with that of the benign group (p < 0.001). FR+CTC (odds ratio, OR, 95% confidence interval, CI: 1.13, 1.07–1.19, p < 0.0001), age (OR, 95% CI: 1.06, 1.01–1.12, p = 0.03) and sex (OR, 95% CI: 1.07, 1.01–1.13, p = 0.01) were independent risk factors of NSCLC in patients with a solitary pulmonary nodule. The area under the curve (AUC) of FR+CTC in diagnosing NSCLC was 0.650 (95% CI, 0.587–0.713) in the training set and 0.700 (95% CI, 0.603–0.796) in the validation set, respectively. The AUC of the combined model was 0.725 (95% CI, 0.659–0.791) in the training set and 0.828 (95% CI, 0.754–0.902) in the validation set, respectively.ConclusionsWe confirmed the value of FR+CTC in diagnosing SPNs and developed a prediction model based on FR+CTC, demographic characteristics, and serum biomarkers for differential diagnosis of solitary pulmonary nodules.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A combined diagnostic model based on circulating tumor cell in patients with solitary pulmonary nodules

Wang

Xiang

Che

et al. 2023

The Journal of Gene Medicine

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Sensitivity and specificity of folate receptor α-positive circulating tumour cells in gastric cancer

Cao,

Liu,

Zhang

et al. 2023

Postgraduate Medical Journal

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Purpose We aimed to investigate whether folate receptor α (FRα)-positive circulating tumour cells (CTCs) could be used as a noninvasive liquid biopsy approach in gastric cancer (GC). Methods Tissue microarray and bioinformatic analyses were used to evaluate FRα expression in GC. Patients with FRα-positive CTC examinations at our institute between July 2021 and May 2022 were retrospectively evaluated. Receiver operating characteristic curves were used to evaluate the diagnostic performance of FRα-positive CTCs in GC. Results FRα was highly expressed and associated with poor prognosis in GC based on public database. Data for 163 patients (20 with benign disease and 143 with GC) were retrospectively collected. FRα-positive CTC levels were significantly higher in the GC group than in the benign disease group (12.15 ± 1.47 FU/3 ml vs. 10.47 ± 1.63 FU/3 ml, P < 0.01). FRα-positive CTC levels were also elevated in GC patients with vessel/neuron invasion or extra-nodal tumour deposits (12.31 ± 1.47 FU/3 ml vs. 11.77 ± 1.38 FU/3 ml, P = 0.037). Areas under the curve of FRα-positive CTC levels for GC and early GC were 0.774 (P < 0.001) and 0.736 (P = 0.005). With a cut-off value of 10.95 FU/3 ml, the Youden indexes for GC and early GC were 0.502 (sensitivity = 85.2% and specificity = 65.0%) and 0.450 (sensitivity = 80.0% and specificity = 65.0%), respectively. Conclusion FRα-positive CTC detection by noninvasive liquid biopsy is a useful and effective approach for screening of patients with GC. Key messages What is already known on this topic Early detection is important in the treatment of gastric cancer. However, noninvasive diagnostic techniques with adequate sensitivity are lacking. What this study adds The diagnostic performance of folate receptor-positive circulating tumour cells was better than that of carcinoembryonic antigen. With the optimal cut-off values, the sensitivities of folate receptor-positive circulating tumour cells in the diagnosis of gastric cancer and early gastric cancer were 85.2% and 80.0%, respectively. How this study might affect research, practice, or policy Folate receptor-positive circulating tumour cell examination is a promising noninvasive approach for the screening of patients with gastric cancer.

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A preliminary study of the clinical significance of folate receptor- positive circulating tumor cell in the management of hepatobiliary- pancreatic cancers

Cited by 2 publications

References 34 publications

A combined diagnostic model based on circulating tumor cell in patients with solitary pulmonary nodules

A combined diagnostic model based on circulating tumor cell in patients with solitary pulmonary nodules

Sensitivity and specificity of folate receptor α-positive circulating tumour cells in gastric cancer

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