A Pregnant Patient with Brittle Type 1 Diabetes Successfully Managed by CSII Therapy with Insulin Aspart

Higuchi, Chigusa; Tone, Atsuhito; Iseda, Izumi; Tsukamoto, Keiko; Katayama, Akihiro; Wada, Jun; Shikata, Kenichi; Hida, Kazuyuki

doi:10.4172/2155-6156.1000104

Cited by 7 publications

(5 citation statements)

References 3 publications

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“…In Type-1 Diabetes, the body produces little or no insulin so those with this type of diabetes need to be on insulin therapy for their entire lives [53]. Type-1 diabetes mellitus is characterized by loss of the insulin-producing beta cells of the islets [54] of Langerhans in the pancreas leading to insulin deficiency [55].…”

Section: Type-1 Diabetesmentioning

confidence: 99%

Role of Diabetes in prevalence of Tuberculosis

Siddiqui¹

2012

J Diabetes Metab

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Tuberculosis is a lethal disease caused by Mycobacterium tuberculosis. The Mycobacterium initially infects lungs. If the infection spreads beyond the lungs, the symptoms will depend upon the individual organs. Diabetes is a type of metabolic disease in which a person has increased blood sugar level. It's because the body does not produce enough insulin or the cells inside the body do not respond to the insulin that is produced. Diabetics have a three to five time's higher risk of developing tuberculosis (TB) than those without diabetes disease. Diabetes mellitus is an important risk factor for tuberculosis and may affect disease treatment and also the response. Additionally tuberculosis may induce glucose intolerance and worsen the glycaemic control in people with diabetes. The main aim of this Review is to evaluate the epidemiology of diabetes mellitus and tuberculosis disease, the effect of diabetes mellitus on tuberculosis and vice versa.  When the immune system of a patient with dormant TB is weakened, the TB can become active (reactivate) and cause infection in lungs or any other parts of the body. The risk factors for acquiring TB include close-contact situations, alcohol, drug abuse and certain diseases (examples include diabetes, cancer, and HIV) and occupations (for example, health-care workers). The common signs and symptoms of TB include fatigue, fever, weight loss, coughing, and night sweats. The diagnosis of TB involves skin tests, chest X-rays, sputum analysis (smear and culture), and PCR tests to detect the genetic material of the causative bacteria or causative agent [12]. Inactive tuberculosis may be treated with an isoniazid (INH), antibiotic, in order to prevent the TB infection from becoming active. Active TB is usually treated, successfully, with INH in combination with one or more of several drugs, including rifampin (Rifadin), ethambutol (Myambutol), pyrazinamide, and streptomycin [13].

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Section: Type-1 Diabetesmentioning

confidence: 99%

Role of Diabetes in prevalence of Tuberculosis

Siddiqui¹

2012

J Diabetes Metab

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“…Continuous subcutaneous insulin infusion (CSII) therapy is widely accepted for brittle type 1 diabetes, since it has the benefit of less frequency of hypoglycemia and better management of the dawn phenomenon compared to multiple daily insulin injection (MDI) therapy [57]. Comparative studies between African and European populations suggest that total lymphocyte count (TLC), including CD4+ count, is likely to vary significantly by ethnicity, in both, healthy and HIV-infected Individuals [58]. Natural killer (NK) cell function was investigated in Malaysian HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency.…”

Section: Gene Therapy and Other Diagnosis Factors In Cure Of Diseasesmentioning

confidence: 99%

The Influence of Environmental and Genetic Factors on Various Disorders and Diseases

Tripathy¹,

Tushar²,

Sudharani³

2011

J Genet Syndr Gene Ther

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Both genetic and environmental factors have been implicated in the mechanism of various disorders. Epidemiological data have shown that environmental factors can also cause and/or exacerbate the pathogenesis of these diseases. However in this article, we provide a summary of evidence for environmental and genetic factors influencing the diseases. The review also incorporates the major findings categorizing the common diseases on the basis of genetic profiles and ethnic information and in establishing personalized disease diagnosis, drug responses and treatment modalities based on the genetic determinants. These studies provide important insights into the interplay between environmental and genetic factors leading to human diseases. Overall an attempt has been made to highlight the importance of studying the genetic profiles of an individual with many factors.

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“…Women who have had gestational diabetes have a 40 to 60 percent chance of developing type2 diabetes within 5 to 10 years. Type1 diabetes can be managed by various Continuous subcutaneous insulin infusion therapies [19]. Women with the history of gestational diabetes mellitus (GDM) have a significantly increased risk of type 2 diabetes and of cardiovascular disease during the next years after delivery [20].…”

Section: Type 2 Diabetesmentioning

confidence: 99%

Late Stage Complications of Diabetes and Insulin Resistance

Soumya¹,

Srilatha²

2011

J Diabetes Metab

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Diabetes mellitus is considered one of the main threats to human health in the 21st century. Diabetes is a metabolic disorder or a chronic condition where the sugar levels in blood are high. Diabetes is associated with long-term complications that affect almost every part of the body and often leads to blindness, heart and blood vessel disease, stroke, kidney failure, amputations, and nerve damage. Also it is associated with significantly accelerated rates of several debilitating microvascular complications such as nephropathy, retinopathy, and neuropathy, and macrovascular complications such as atherosclerosis and stroke. In the present article it has been discussed about the resistance of insulin and its consequences in diabetic patients. Insulin resistance results in various disorders. Metabolic syndrome is predicted to become a major public health problem in many developed, as well as developing countries. J ou rna l o f D ia be tes & M e ta bolism

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A Pregnant Patient with Brittle Type 1 Diabetes Successfully Managed by CSII Therapy with Insulin Aspart

Cited by 7 publications

References 3 publications

Role of Diabetes in prevalence of Tuberculosis

Role of Diabetes in prevalence of Tuberculosis

The Influence of Environmental and Genetic Factors on Various Disorders and Diseases

Late Stage Complications of Diabetes and Insulin Resistance

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