A preferential increase in the extrastriate response to signals of danger

Surguladze, Simon; Brammer, Michael; Young, Andrew W.; Andrew, Christopher; Travis, Michael J.; Williams, Steven; Phillips, Mary L.

doi:10.1016/s1053-8119(03)00085-5

Cited by 185 publications

(158 citation statements)

References 44 publications

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“…Aversive faces also activated posterior OFC on the right, lateral frontal cortex, and temporal poles on both sides, occipital and extrastriate regions, particularly fusiform gyrus, again broadly consistent with other studies (Keightley et al, 2003;Lange et al, 2003;Gur et al, 2002;Abel et al, 2003;Surguladze et al, 2003;Sprengelmeyer et al, 1998).…”

Section: Covert Face Emotion Recognitionsupporting

confidence: 90%

“…There are less consistent findings with other emotions such as anger (eg Blair et al, 1999;Hariri et al, 2002) and disgust (Phillips et al, 1997;Winston et al, 2003), perhaps reflecting a stronger reaction to fear than other emotions rather than a truly selective response (Whalen et al, 2001). Previous imaging studies using emotional face stimuli have also shown activation of medial and orbital prefrontal cortices, including anterior cingulate, insula and regions of the occipital cortex, particularly the fusiform gyrus (Sprengelmeyer et al, 1998;Blair et al, 1999;Surguladze et al, 2003;Abel et al, 2003;Keightley et al, 2003). Depressed and anxious patients have been shown to have altered neural responses to negative emotional faces (Lawrence et al, 2004;Thomas et al, 2001;Sheline et al, 2001).…”

Section: Introductionmentioning

confidence: 91%

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The Effect of Citalopram Pretreatment on Neuronal Responses to Neuropsychological Tasks in Normal Volunteers: An fMRI Study

Del-Ben

Deakin

McKie

et al. 2005

Neuropsychopharmacol

238

184

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Changes in serotonin neurotransmission have also been implicated in the etiology and treatment of impulse control disorders, depression, and anxiety. We have investigated the effect of enhancing serotonin function on fundamental brain processes that we have proposed are abnormal in these disorders. In all, 12 male volunteers received citalopram (7.5 mg intravenously) and placebo pretreatment in a single-blind crossover design before undertaking Go/No-go, Loss/No-loss, and covert (aversive) face emotion recognition tasks during functional magnetic resonance imaging (fMRI). Blood oxygenation level dependent responses were analyzed using Statistical Parametric Mapping (SPM2). The tasks activated prefrontal and subcortical regions generally consistent with literature with lateral orbitofrontal cortex (BA47) common to the three tasks. Citalopram pretreatment enhanced the right BA47 responses to the No-go condition, but attenuated this response to aversive faces. Attenuations were seen following citalopram in the medial orbitofrontal (BA11) responses to the No-go and No-loss (ie relative reward compared with Loss) conditions. The right amygdala response to aversive faces was attenuated by citalopram. These results support the involvement of serotonin in modulating basic processes involved in psychiatric disorders but argue for a process-specific, rather than general effect. The technique of combining drug challenge with fMRI (pharmacoMRI) has promise for investigating human psychiatric disorders.

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Section: Covert Face Emotion Recognitionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 91%

The Effect of Citalopram Pretreatment on Neuronal Responses to Neuropsychological Tasks in Normal Volunteers: An fMRI Study

Del-Ben

Deakin

McKie

et al. 2005

Neuropsychopharmacol

238

184

View full text Add to dashboard Cite

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“…Several functional imaging studies reported that brain regions in the visual cortex exhibit stronger activation to emotional faces than to neutral faces, including faceselective areas in the fusiform gyrus ( Ishai et al, 2004;Surguladze et al, 2003;Vuilleumier et al, 2001;Winston et al, 2003). Further, cerebral regions such as the amygdala, insula, hippocampal regions, striatum, cingulate cortex as well as prefrontal areas are involved in the processing of emotion perception (Phillips et al, 2003).…”

Section: Decreased Activation During Facial Emotion Processing In Juvmentioning

confidence: 99%

Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia

Seiferth

Pauly

Kellermann

et al. 2008

Neuropsychopharmacol

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Emotion discrimination deficits represent a well-established finding in schizophrenia. Although imaging studies addressed the cerebral dysfunctions underlying emotion perception in adult patients, the question of trait vs state characteristics is still unresolved. The investigation of juvenile patients offers the advantage of studying schizophrenia at an age where influences of illness course and long-term medication are minimized. This may enable a more detailed characterization of emotion discrimination impairments and their cerebral correlates with respect to their appearance and exact nature. A total of 12 juvenile patients with early onset schizophrenia and matched healthy juveniles participated in this study. fMRI data were acquired during an emotion discrimination task consisting of standardized photographs of faces displaying happy, sad, angry, fearful, or neutral facial expression. Similar to findings in adult patients, juvenile patients exhibited reduced performance specificity whereas sensitivity was unaffected. Independent of the valence, their processing of emotional faces was associated with hypoactivations in both fusiform gyri and in the left inferior occipital gyrus. In addition, hyperactivations in patients were found in the right cuneus common to happy, angry, and fearful faces. Further, most distinct changes were present in juvenile patients when processing sad faces. These results point to a dysfunction in cerebral circuits relevant for emotion processing already prominent in adolescent schizophrenia patients. Regions affected by a decrease in activation are related to visual and face processing, similar to deficits reported in adult patients. These changes are accompanied by hyperactivations in areas related to emotion regulation and attribution, possibly reflecting compensatory mechanisms.

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“…Activation of this area in response to facial emotion stimuli has been reported in neuroimaging studies employing similar facial emotion processing tasks [60,103]. In addition, BA 6 is also active during the production of empathetic facial expressions [109][110][111].…”

Section: Discussionmentioning

confidence: 59%

ISDN2014_0211: An fMRI study of facial emotion processing in children and adolescents with 22q11.2 deletion syndrome

Azuma

Deeley

Campbell

et al. 2015

Intl J of Devlp Neuroscience

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Background: 22q11.2 deletion syndrome (22q11DS, velo-cardio-facial syndrome [VCFS]) is a genetic disorder associated with interstitial deletions of chromosome 22q11.2. In addition to high rates of neuropsychiatric disorders, children with 22q11DS have impairments of face processing, as well as IQ-independent deficits in visuoperceptual function and social and abstract reasoning. These face-processing deficits may contribute to the social impairments of 22q11DS. However, their neurobiological basis is poorly understood. Methods: We used event-related functional magnetic resonance imaging (fMRI) to examine neural responses when children with 22q11DS (aged 9-17 years) and healthy controls (aged 8-17 years) incidentally processed neutral expressions and mild (50%) and intense (100%) expressions of fear and disgust. We included 28 right-handed children and adolescents: 14 with 22q11DS and 14 healthy (including nine siblings) controls.

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A preferential increase in the extrastriate response to signals of danger

Cited by 185 publications

References 44 publications

The Effect of Citalopram Pretreatment on Neuronal Responses to Neuropsychological Tasks in Normal Volunteers: An fMRI Study

The Effect of Citalopram Pretreatment on Neuronal Responses to Neuropsychological Tasks in Normal Volunteers: An fMRI Study

Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia

ISDN2014_0211: An fMRI study of facial emotion processing in children and adolescents with 22q11.2 deletion syndrome

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