A preclinical study comparing single- and double-root 3D-printed Ti–6Al–4V implants

Chung, Inna; Lee, Jung Won; Li, Ling; Seol, Yang‐Jo; Lee, Yong-Moo; Koo, Ki‐Tae

doi:10.1038/s41598-023-27712-2

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…Previously, our group established a digital workflow for the fabrication of double-root 3DIs that were designed in the shape of lattice- and solid-type roots, and found that the macrodesign of the implants may affect the secondary stability in vivo 15 . Furthermore, another study performed by our group comparing single and double-root 3DIs showed comparable implant stability and peri-implant bone remodeling, whereas higher marginal bone loss was observed in the furcation areas of double-root 3DIs 18 . However, there have been few related studies that fundamentally compared the in vivo clinical outcomes of 3DIs and CIs.…”

Section: Introductionmentioning

confidence: 70%

“…Numerous studies of 3DIs have shown favorable clinical outcomes in vivo and have indicated a demand for further investigations into the actual implementation of 3DIs 15 – 18 . Previously, our group established a digital workflow for the fabrication of double-root 3DIs that were designed in the shape of lattice- and solid-type roots, and found that the macrodesign of the implants may affect the secondary stability in vivo 15 .…”

Section: Introductionmentioning

confidence: 99%

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Comparative evaluation of 3D-printed and conventional implants in vivo: a quantitative microcomputed tomographic and histomorphometric analysis

Suh,

Lee,

Lee

et al. 2023

Sci Rep

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In recent years, 3D-printing technology to fabricate dental implants has garnered widespread attention due to its patient-specific customizability and cost-effectiveness. This preclinical animal study analyzed the radiographic and histomorphometric outcomes of 3D-printed implants (3DIs) placed immediately after extraction and compared them to conventional implants (CIs). 3DIs and CIs of the same dimensions placed immediately were analyzed at 2, 6, and 12 weeks. The micro-computed tomography (micro-CT) analysis revealed statistically significant differences at 2 weeks in favor of 3DIs over the CIs in terms of bone volume/tissue volume (BV/TV), bone surface/bone volume (BS/BV), trabecular bone pattern factor (Tb.Pf), and structure model index (SMI). At 2 weeks, the mean bone-to-implant contact (BIC) of the 3DIs was greater than that of the CIs; the mean bone area fraction occupancy (BAFO) and the number of Haversian canals of the 3DIs showed no statistically significant differences compared to CIs at 2 weeks. At 6 and 12 weeks, there were no statistically significant differences between the 3DIs and CIs in any parameters. Within limitations, in the early stage of extraction socket healing, the 3DIs demonstrated a higher BIC than the CIs, presenting that 3DIs may be a potential option for immediate placement to enhance osseointegration.

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Section: Introductionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of 3D-printed and conventional implants in vivo: a quantitative microcomputed tomographic and histomorphometric analysis

Suh,

Lee,

Lee

et al. 2023

Sci Rep

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“…Block biopsies including the experimental sites were obtained 6 weeks after the first surgery. Prior to histological preparation, micro-computed tomography (micro-CT) data of the samples were obtained, using the same conditions as in a previous study (13.3-μm resolution, 60 kV energy, and 167 μA intensity using 0.5-mm aluminum filter) 27 . The scanned images were reconstructed using software (DataViewer 1.5.2.4 64-bit version, Bruker microCT, Skyscan, Kontich, Belgium) and the data were analyzed with CTAn software (Bruker-CT, Kontich, Belgium).…”

Section: Methodsmentioning

confidence: 99%

“…The scanned images were reconstructed using software (DataViewer 1.5.2.4 64-bit version, Bruker microCT, Skyscan, Kontich, Belgium) and the data were analyzed with CTAn software (Bruker-CT, Kontich, Belgium). In accordance with previous studies 27 , 28 , 8-bit grayscale values ranging from 30 to 80 was set to identify bone tissue. Bone volume/tissue volume (BV/TV), bone surface/bone volume (BS/BV), the trabecular bone pattern factor (Tb.Pf), and structure model index (SMI) values within the VOI were calculated.…”

Section: Methodsmentioning

confidence: 99%

Effect of polydeoxyribonucleotide on early bone formation in lateral bone augmentation with immediate implant placement: an experimental in vivo study

Lee,

Seol

et al. 2023

Sci Rep

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This study investigated early bone formation using collagenated biphasic calcium phosphate (CBCP) with or without polynucleotide (PDRN). Third (P3) or fourth (P4) premolars of six male beagle dogs were extracted and 5-mm-high dehiscence defects were created, followed by 3D-printed implant placement. The buccal bone defects were grafted with (i) CBCP and collagen membrane or (ii) CBCP soaked in polydeoxyribonucleotide (CBCP/PDRN) and collagen membrane. Samples of the experimental sites were harvested at 2- and 6-weeks post-surgery. The specimens were evaluated with radiologic and histomorphometric analysis. No significant differences were found between the CBCP and CBCP/PDRN groups in the micro-CT analysis at 2 or 6 weeks. No significant differences were observed in bone-to-implant contact (BIC) or bone area fraction occupancy (BAFO) in buccal augmented and lingual non-augmented areas. In the qualitative analysis, the new bone (NB) area and NB proportion in buccal augmented areas showed significantly higher values in the CBCP/PDRN group than in the CBCP group at 2 and 6 weeks. Peri-implant buccal dehiscence defects with immediate 3D-printed implant placement were corrected using a collagen membrane and CBCP or CBCP/PDRN. PDRN might have the potential to facilitate early bone formation with sufficient stability over time in dehiscence defects.

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“…In a study by Zhong et al [122], double-root 3D tomography, micro-computed tomography (micro-CT), and histological analysis of a 3D printed implant were conducted. It was found that the stability and bone remodeling around the fixation of the 3D-printed double-root implant were comparable.…”

Section: Different Structures Of the Tooth Rootmentioning

confidence: 99%

Research Progress on the Preparation Process and Material Structure of 3D-Printed Dental Implants and Their Clinical Applications

Gao,

Pan,

Gao

et al. 2024

Coatings

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Additive manufacturing, commonly known as 3D printing technology, has become a prominent topic of research globally in recent years and is playing an increasingly important role in various industries. Particularly within the healthcare sector, the use of 3D printing technology is gaining prominence, with a special focus on the manufacturing and application of dental implants. As research in this field progresses, the preparation methods, material selection, and technological innovations for dental implants are evolving, promising a future where the manufacturing process of dental implants becomes even more refined and efficient. Through thorough research in materials science, it is possible to develop dental implant materials that have better biocompatibility with the human body and improved mechanical properties. Additionally, advancements in surface modification technology can further enhance the strength and stability of the bond between dental implants and bone tissue. These advancements not only expand treatment options for patients but also greatly improve the long-term success rate of dental implants. In the field of dental implants, the success of the implant depends on the interactions between the materials used, the cells involved, and the bone tissue. Therefore, there is an urgent need to explore the molecular mechanisms of such interactions in depth. In this study, we provide a comprehensive review of the application of 3D printing technology in the fabrication of dental implants. This includes an examination of the process methods, surface coating technology, and a comparison of the shapes and structures of different dental implants, along with their advantages and disadvantages. Furthermore, this paper analyzes the intrinsic mechanisms of successful dental implant placement in clinical practice, and it highlights the latest progress in the clinical application of 3D-printed dental implants. Undeniably, the use of 3D-printed dental implants not only offers patients more precise and personalized treatment plans but also brings revolutionary changes to the development of the medical industry.

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A preclinical study comparing single- and double-root 3D-printed Ti–6Al–4V implants

Cited by 8 publications

References 24 publications

Comparative evaluation of 3D-printed and conventional implants in vivo: a quantitative microcomputed tomographic and histomorphometric analysis

Comparative evaluation of 3D-printed and conventional implants in vivo: a quantitative microcomputed tomographic and histomorphometric analysis

Effect of polydeoxyribonucleotide on early bone formation in lateral bone augmentation with immediate implant placement: an experimental in vivo study

Research Progress on the Preparation Process and Material Structure of 3D-Printed Dental Implants and Their Clinical Applications

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