A Prebiotic Selection of β-Furanoside-5'-Phosphate as the Sole Configuration toward the Synthesis of Extant RNA
Ze-Run Zhao,
Hao-Xing Xu,
Cheng-Cheng Gu
et al.
Abstract:The cause of the selection of β-furanoside-5'-phosphate as the backbone configuration of RNA during life’s origins has not been fully determined. Previous attempts were mostly unsuccessful in demonstrating either a selective synthesis or a selection mechanism for β-furanoside and 5'-nucleotide in the nucleosidation and phosphorylation steps. These questions are answered in this study. Inspired by the chromatographic elution order of nucleoside and nucleotide isomers, a unique separation mechanism has been esta… Show more
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