volume 28, issue 6, P739-745 2014
DOI: 10.3109/02688697.2014.915007
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Weichuan Wu, Runfa Tian, Shuyu Hao, Feifan Xu, Xiang Mao, Baiyun Liu

Abstract: Drinking is a risk factor for traumatic brain injury (TBI), and ethanol can aggravate the outcome by promoting brain edema. The mechanism involved is not fully understood. It has been confirmed that aquaporin-4 (AQP4) and vascular endothelial growth factor (VEGF) play pivotal roles in cytotoxic/vasogenic brain edema individually, and both of these proteins are downstream regulatory factors of hypoxia-inducible factor-1α (HIF-1α). In this study, we used a fluid percussion injury (FPI) model in rats to determine…

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