A Practical Guide and Perspectives on the Use of Experimental Pain Modalities with Children and Adolescents

Birnie, Kathryn A.; Caes, Line; Wilson, Anna; Williams, Sara E.; Chambers, Christine T.

doi:10.2217/pmt.13.72

Cited by 48 publications

(59 citation statements)

References 93 publications

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“…However, experimental measurement of central pain processing is relatively complex and not commonly conducted in children 1 . Assessment of the spatial distribution of pain is potentially a non-invasive surrogate measure to assess the presence of central pain augmentation that is feasible in the clinical setting.…”

Section: Discussionmentioning

confidence: 99%

Association Between Widespread Pain Scores and Functional Impairment and Health-Related Quality of Life in Clinical Samples of Children

Rabbitts

Holley

Groenewald

et al. 2016

The Journal of Pain

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Pain involving several body regions generally represents nervous system pathophysiology shifting from predominantly peripheral to more central. In adults, higher widespread pain scores are clinically meaningful and confer risk for poor response to treatment. It is unknown whether widespread pain is similarly important in children. To address this gap, we conducted an observational study examining (1) associations between widespread pain and functional impairment and health-related quality of life (HRQOL) in clinical pediatric samples, and (2) associations among sociodemographic factors and pain catastrophizing with widespread pain scores. Participants were 166 children age 10-18 years from three samples (acute pain, pre-surgery, chronic pain). Children self-reported pain intensity, pain catastrophizing, functional impairment and HRQOL. Children indicated pain locations on a body diagram, which was coded using the American College of Rheumatology definition of widespread pain. Results revealed higher widespread pain scores were associated with greater functional impairment with routine activities (F=3.15, p=0.02) and poorer HRQOL (F=3.29, p=0.02), adjusting for pain intensity, study group and demographics. Older age (B=0.11, p=0.01), and Hispanic ethnicity (B=0.67, p=.03) were associated with higher widespread pain scores. Findings support incorporating evaluation of widespread pain into pediatric pain assessment. Future research is needed to examine longitudinal impact of widespread pain on children's treatment outcomes.

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Section: Discussionmentioning

confidence: 99%

Association Between Widespread Pain Scores and Functional Impairment and Health-Related Quality of Life in Clinical Samples of Children

Rabbitts

Holley

Groenewald

et al. 2016

The Journal of Pain

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show abstract

“…Additionally, this finding reflects the mostly clinical orientation of pediatric pain research, but the relative lack of basic science exploring biomedical mechanisms specific to pediatric pain experiences. This orientation might also be partially explained by ethical challenges involved in applying methodologies to investigate underlying pain mechanisms (e.g., imaging, experimental pain induction) within a vulnerable sample of children [6].…”

Section: Discussionmentioning

confidence: 99%

A comprehensive categorical and bibliometric analysis of published research articles on pediatric pain from 1975 to 2010

Caes

Boerner

Chambers

et al. 2016

Pain

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2 SUMMARYUsing categorical and bibliometric meta-trend analysis methods, this article provides a comprehensive overview of published peer-reviewed research articles on pediatric pain from 1975-2010. ABSTRACTThe field of pediatric pain research began in the mid-1970's and has undergone significant growth and development in recent years as evidenced by the variety of books, conferences, and journals on the topic as well as the number of disciplines engaged in work in this area.Using categorical and bibliometric meta-trend analysis, the current study offers a synthesis of research on pediatric pain published between 1975 and 2010 in peer-reviewed journals.Abstracts from 4256 articles, retrieved from Web of Science, were coded across four categories: article type, article topic, type and age of participants, and pain stimulus. The affiliation of the first author and number of citations were also gathered. The results suggest a significant increase in the number of publications over the time period investigated, with 96% of the included articles published since 1990 and most research being multi-authored publications in pain-focused journals. First authors were most often from the United States, and affiliated with a medical department. The majority of studies were original research articles; the most frequent topics were pain characterization (39.86%), pain intervention (37.49%), and pain assessment (25.00%). Clinical samples were most frequent, with participants most often characterized as children (6-12 years) or adolescents (13-18 years) experiencing chronic or acute pain. The findings provide a comprehensive overview of contributions in the field of pediatric pain research over 35 years and offers recommendations for future research in the area.3

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“…Pressure pain thresholds were measured during the first experimental session (pre/post 20 minutes quiet rest) and pre/post maximal aerobic exercise (treadmill session) at three sites: left 4 th finger nailbed, left middle deltoid muscle (one quarter the distance from the acromion to the lateral epicondyle), and right quadriceps muscle (half the distance from the anterior superior iliac crest to the superior patella) (2). Three trials were completed at each site with a 10 second inter-stimulus interval, and the site order were randomized at each session.…”

Section: Methodsmentioning

confidence: 99%

Pain Response after Maximal Aerobic Exercise in Adolescents across Weight Status

Stolzman

Danduran

Hunter

et al. 2015

Medicine &Amp; Science in Sports &Amp; Exercise

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Introduction Pain reports are greater with increasing weight status, and exercise can reduce pain perception. It is unknown however, whether exercise can relieve pain in adolescents of varying weight status. The purpose of this study was to determine if adolescents across weight status report pain relief following high intensity aerobic exercise (exercise-induced hypoalgesia [EIH]). Methods 62 adolescents (15.1±1.8 years, 29 males) participated in three sessions: 1) Pressure pain thresholds (PPTs) before and after quiet rest, clinical pain (McGill Pain Questionnaire), and physical activity levels (self-report and ActiSleep Plus Monitors) were measured; 2) PPTs were measured with a computerized algometer at the 4th finger nailbed, middle deltoid muscle, and quadriceps muscle before and after maximal oxygen uptake test (VO2 max Bruce Treadmill Protocol); and 3) Body composition was measured with Dual-energy X-ray absorptiometry. Results All adolescents met criteria for VO2 max. Based on body mass index z-score, adolescents were categorized as normal weight (n=33) or overweight/obese (n=29). PPTs increased following exercise (EIH) and were unchanged with quiet rest (trial × session: p=0.02). EIH was similar across the 3 sites and between normal weight and overweight/obese adolescents. Physical activity and clinical pain were not correlated with EIH. Overweight/obese adolescents had similar absolute VO2 max (L·min-1) but lower relative VO2 max (ml·kg-1·min-1) compared with normal weight adolescents. When adolescents were categorized using FitnessGram standards as unfit (n=15) and fit (n=46), the EIH response was similar between fitness levels. Conclusion This study is the first to establish that adolescents experience EIH in both overweight and normal weight youth. EIH after high intensity aerobic exercise was robust in adolescents regardless of weight status and not influenced by physical fitness.

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A Practical Guide and Perspectives on the Use of Experimental Pain Modalities with Children and Adolescents

Cited by 48 publications

References 93 publications

Association Between Widespread Pain Scores and Functional Impairment and Health-Related Quality of Life in Clinical Samples of Children

Association Between Widespread Pain Scores and Functional Impairment and Health-Related Quality of Life in Clinical Samples of Children

A comprehensive categorical and bibliometric analysis of published research articles on pediatric pain from 1975 to 2010

Pain Response after Maximal Aerobic Exercise in Adolescents across Weight Status

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