A Possible Association Between Thyroid Cancer and Breast Cancer

An, Jee Hyun; Hwangbo, Yul; Ahn, Hwa Young; Keam, Bhumsuk; Lee, Kyu Eun; Han, Wonshik; Park, Do Joon; Park, In Ae; Noh, Dong Young; Youn, Yeo-Kyu; Cho, Bo Youn; Im, Seock Ah; Park, Young Joo

doi:10.1089/thy.2014.0561

Cited by 67 publications

(74 citation statements)

References 25 publications

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“…These results are in agreement with previous studies showing that TC in patients with BC was diagnosed at an earlier stage than ordinary TC and is specific for papillary TC . Similarly, An et al reported that after excluding incidentally detected cases by imaging modalities during follow‐up of BC, the SIR for secondary TC decreased from 2.18 to 1.73 in a Korean cohort.…”

Section: Discussionsupporting

confidence: 91%

“…The incidence of TC was 1.8% in 13 978 patients with BC, and the SIR of secondary TC for female patients with BC was as high as 4.48 (95% CI, 3.95‐5.44) compared with Chinese females in the general population and was 2.52 (95% CI, 2.22‐3.06) compared with areas of high urbanization. These results are comparable with those of previous studies, which showed an SIR ranging from 1.16 to 4.75 in patients with BC . More active surveillance of BC could lead to more incidental diagnoses of TC.…”

Section: Discussionsupporting

confidence: 90%

“…Thyroid cancer (TC) is the most prevalent endocrine malignancy among women. Epidemiologic studies have indicated that patients with BC have a higher risk of developing TC as an SPM, and vice versa, than would be expected in the general population; and the risk of BC following TC is increased by 21% to 89% and that of TC following BC by 31% to 73% . Therefore, these cancers might share some etiologies in common, including hormonal factors, a genetic predisposition, and environment‐ and therapy‐related factors.…”

Section: Introductionmentioning

confidence: 99%

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Association between breast cancer and thyroid cancer: A study based on 13 978 patients with breast cancer

et al. 2018

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BackgroundThyroid cancer (TC) is one of the most commonly seen secondary malignancy in breast cancer (BC) survivors.Materials and methodsA retrospective study was conducted in BC patients in our center from 1999 to 2013. Patients were divided into BC‐TC group and BC‐alone group.ResultsIn total, 13 978 BC patients were identified, among whom 247 (1.8%) had TC. The standardized incidence ratio (SIR) of TC was 4.48 compared with Chinese females, and up to 98.0% of cases were thyroid papillary carcinomas. A family history of malignancy was the only independent risk factor (odds ratio = 1.457, P = 0.025) for development of TC in patients with BC. We also identified inferior survival in patients with synchronous versus metachronous BC‐TC (P = 0.016). Synchronous BC‐TC (risk ratio = 5.597, P = 0.018) was an independent prognostic factor for inferior RFS.ConclusionsWe observed high co‐occurrence of TC in patients with BC. There might be different mechanisms behind synchronous and metachronous BC‐TC.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Association between breast cancer and thyroid cancer: A study based on 13 978 patients with breast cancer

et al. 2018

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“…The latter ones include genetic susceptibility, as is the case for Cowden and Cowden-like syndromes (89), as well as a common molecular mechanism mediated by sex steroid receptors. In this regard, compared to control groups of breast cancer as the only malignancy, the expression of both ER and progesterone receptor (PR) was found to be significantly increased in breast cancer specimens from women who also had DTC, regardless of which of the two cancers had occurred first and/or of the latency to detection of the second malignancy (90, 91). Interestingly, evidence has been provided showing that rearranged during transfection/papillary thyroid carcinoma (RET/PTC) oncogene is induced by estrogen in breast cancer cells, and the RET/PTC kinase signaling enhances estrogen-driven cell proliferation (92, 93).…”

Section: Resultsmentioning

confidence: 99%

Female Reproductive Factors and Differentiated Thyroid Cancer

et al. 2017

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Differentiated thyroid cancer (DTC) is markedly more common in women than men, the highest female-to-male ratio being recorded during the reproductive period. This evidence has led to the suggestion that female hormonal and reproductive factors may account for the observed DTC gender disparity. This review focuses on current evidence on the risk of DTC in conjunction with major female reproductive factors, including the impact of pregnancy on DTC occurrence and progression/recurrence. Overall, studies exploring the link between the risk of DTC and menstrual and menopausal factors, oral contraceptives and/or hormone replacement therapy, showed these associations, if any, to be generally weak. Nonetheless, there is some evidence that higher levels of exposure to estrogens during reproductive years may confer an increased risk of DTC. As far as pregnancy is concerned, it is unclear whether a potential association between parity and risk of DTC actually exists, and whether it is enhanced in the short-term following delivery. A possible role for pregnancy-related factors in DTC progression has been recently suggested by some reports, the results of which are consistent with a worse outcome in the short-term of women diagnosed with DTC during gestation compared to non-pregnant control patients. Also, some progression of disease has been described in women with structural evidence of disease prior to pregnancy. However, there seems to be no impact from pregnancy in DTC-related death or overall survival. Several in vitro and animal studies have evaluated the influence of estrogens (E) and estrogen receptors (ERs) on thyroid cell proliferation. Presently available data are indicative of a role of E and ERs in thyroid cancer growth, although considerable discrepancies in respect to ER expression patterns in thyroid cancer tissues actually exist. Further studies providing more direct evidence on the possible role of E and of placental hormones and growth factors on thyroid growth may expand our knowledge on the mechanisms beyond the gender disparity of proliferative thyroid diseases.

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“…The SIR value was calculated according to the estimated incidence of BC (37.86/100,000) and TC (10.32/ 100,000) in China in 2011 [11]. The SIR value of TC was higher compared with the value obtained in previous studies (from 1.2 to 4.6) [12–15]. The increased incidence of TC followed by the occurrence of BC might be attributed to the incidental detection of TC during follow-up of BC or to the frequent health check-ups following BC.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and survival of patients with metachronous or synchronous double primary malignancies: breast and thyroid cancer

Zhang

Liu

et al. 2016

Oncotarget

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BackgroundClinical experiences suggest that breast cancer (BC) and thyroid cancer (TC) occur metachronously or synchronously in a patient more frequently than it would by chance. This study was conducted to investigate the clinicopathological characteristics and survival of these double primary malignancies.Methods18732 patients with first primary BC and 12877 female patients with first primary TC were performed in this retrospective case-controlled study. The control groups were matched with both age at diagnosis and time of surgery (±2 years). The clinicopathological factors, Overall survival (OS), and HRs were evaluated by SPSS.ResultsThere were 91(0.49%) BC patients developed metachronous second primary TC (B-T group), and 117 (0.91%) TC patients developed metachronous second primary BC (T-B group). The expression of estrogen and progesterone receptors, and the value of Ki-67, were significantly higher in the B-T group than control. The median value of thyroid globulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) were higher in T-B group than control (p <0.05). The duration before second primary cancer was shorter for the B-T group than the T-B group (4.09 years vs. 5.82 years, p<0.001). B-T group patients showed poorer survival than BC only patients (p=0.044).ConclusionsIn general, the overall risk of the occurrence of a second primary TC or BC elevated highly in patients with BC or TC. Detailed mechanisms need to be studied to explore the association between these two cancers. Early detection and effective prevention for the first primary BC or TC patients are necessities for reducing the incidence of the second primary cancer and improving the OS.

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A Possible Association Between Thyroid Cancer and Breast Cancer

Cited by 67 publications

References 25 publications

Association between breast cancer and thyroid cancer: A study based on 13 978 patients with breast cancer

Association between breast cancer and thyroid cancer: A study based on 13 978 patients with breast cancer

Female Reproductive Factors and Differentiated Thyroid Cancer

Characteristics and survival of patients with metachronous or synchronous double primary malignancies: breast and thyroid cancer

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