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Cited by 4 publications
(5 citation statements)
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References 8 publications
(13 reference statements)
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“…58 NK cells at the implantation site would sense trophoblast invasion by responding to the soluble HLA-G produced by these invading fetal cells. Endosomal signaling by KIR2DL4 in response to HLA-G would result in the reprogramming of NK cells to a senescent state.…”
Section: A Role For Senescence In Reproductionmentioning
confidence: 99%
See 1 more Smart Citation
“…58 NK cells at the implantation site would sense trophoblast invasion by responding to the soluble HLA-G produced by these invading fetal cells. Endosomal signaling by KIR2DL4 in response to HLA-G would result in the reprogramming of NK cells to a senescent state.…”
Section: A Role For Senescence In Reproductionmentioning
confidence: 99%
“…Senescence of decidual NK cells upon sensing soluble HLA-G secreted by trophoblast cells would arrest cells, while promoting the secretion of factors that would favor remodeling at this site. 58 In this regard, two studies have revealed an unexpected role for senescence during normal development. 65,66 Markers of senescence such as SAbG were used to identify senescent cells at specific stages and in distinct patterns in the developing embryo.…”
Section: A Role For Senescence In Reproductionmentioning
confidence: 99%
“…As engagement of 2DL4 via this pathway is a molecular switch for a SASP, these signals are likely to promote vascular permeability and angiogenesis at sites of HLA-G expression, such as in the maternal decidua during early pregnancy. We have previously proposed that a positive role of senescence is to favor reproduction through sustained NK activation to remodel maternal vasculature early in pregnancy (28). HLA-G expression has also been detected de novo during viral infections, transplantation, autoimmunity and upon malignant transformation of healthy cells (7).…”
Section: Discussionmentioning
confidence: 99%
“…The factors secreted by dNK cells, including chemokines, cytokines and vasoactive factors, such as IL-8, TGF-β, angiopoietin-1/2 (Ang1/2), and VEGF-C, initiate destabilization of vascular structures and, thus, SA transformation ( 59 , 67 , 68 ). As mentioned above, sHLA-G from EVT induces a senescent state in NK cells capable of participating in SA remodeling by secreting a series of factors (TNF-α, IL-1β, IFN-γ, IL-6, IL-8 ( 28 ).…”
Section: The Role Of Dnk Cells In Normal Pregnancymentioning
confidence: 98%
“…There is also evidence that dNK cells can be induced for a senescent phenotype by interacting with HLA-G from trophoblasts during pregnancy ( 26 , 27 ). The NK cells of senescent phenotype would produce pro-inflammatory factors and pro-angiogenic factors that contribute to for trophoblast invasion and spiral artery remodeling ( 28 ).…”
Section: Characteristics and Subtypes Of Dnk Cells In Human Pregnancymentioning
confidence: 99%