A positive feedback loop of miR-30a-5p-WWP1-NF-κB in the regulation of glioma development

Zhao, Peichao; Wang, Mengmeng; An, Jiyang; Sun, Hongwei; Li, Tianhao; Li, Dongming

doi:10.1016/j.biocel.2019.04.003

Cited by 15 publications

(17 citation statements)

References 16 publications

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“…miR-30a-5p was increased and as a potential biomarker for ovarian serous adenocarcinoma [16]. In addition, the expression of miR-30a-5p was increased in glioma tissues and promoted glioma cell proliferation, migration, and invasion via targeting WWP1 [12]. These consistent with our present data.…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, the down-regulation of miR-30a-5p was associated with poor prognosis and promoted chemoresistance of gemcitabine in pancreatic ductal adenocarcinoma [19]. However, it has been also reported that overexpression of miR-30a-5p contributed to initiation and progression of some tumors [12,16]. miR-30a-5p was increased and as a potential biomarker for ovarian serous adenocarcinoma [16].…”

Section: Discussionmentioning

confidence: 98%

“…The miR-30 family, which contains five members of distinct pre-mature miRNAs (miR-30a, -30b, -30c, -30d, -30e), has been proved to play diverse roles in regulating essential aspects of tumorigenesis, metastasis, chemo-resistance and clinical prognosis in several types of human cancers [11,12]. A large number of reports have demonstrated that miR-30a-5p, as a member of the mir-30 family, was down-regulated and associated with tumorigenesis and progression of prostate cancer, hepatocellular carcinoma, breast tumor and some other cancers [13][14][15].…”

Section: Ivyspring International Publishermentioning

confidence: 99%

“…A large number of reports have demonstrated that miR-30a-5p, as a member of the mir-30 family, was down-regulated and associated with tumorigenesis and progression of prostate cancer, hepatocellular carcinoma, breast tumor and some other cancers [13][14][15]. However, it has been reported that overexpression of miR-30a-5p contributed to initiation and progression of some tumors [12,16]. However, the expression and role of miR-30a-5p in CCA progression remain unclear.…”

Section: Ivyspring International Publishermentioning

confidence: 99%

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MiR-30a-5p promotes cholangiocarcinoma cell proliferation through targeting SOCS3

Zhang¹,

Wang²,

Li³

et al. 2020

J. Cancer

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Background: MicroRNAs (miRNAs) play important roles in the occurrence and development of cancers. In this project, we aimed to explore the role and molecular mechanism of mir-30a-5p in cholangiocarcinoma (CCA). Materials and Methods:The expression profile and clinical significance of miR-30a-5p in CCA patients were investigated in 31 ICC and 52 ECC patients respectively. The role and mechanism of miR-30a-5p in CCA cells were investigated by up-regulating and inhibiting miR-30a-5p expression in vitro functional study. Results: The expression of miR-30a-5p was increased in both CCA tissues and cells. The inhibition of miR-30a-5p decreased cell proliferation and induced cell apoptosis while overexpression of miR-30a-5p achieved the opposite effect. Furthermore, SOCS3 was down-regulated in ICC and ECC tissues and negatively regulated by miR-30a-5p. Dual-luciferase reporter assay revealed that co-transfection of miR-30a-5p significantly inhibited the activity of firefly luciferase reporter carrying the wild-type 3′UTR of SOCS3. The inhibition of SOCS3 could largely rescue the inhibitory effect of miR-30a-5p inhibition on CCA cells proliferation. In clinical, up-regulated miR-30a-5p expression was correlated with large tumor size in both ICC and ECC cohorts. Conclusions: miR-30a-5p promoted CCA cells proliferation through targeting SOCS3. These findings suggested that miR-30a-5p could be a potential therapeutic target.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Section: Ivyspring International Publishermentioning

confidence: 99%

Section: Ivyspring International Publishermentioning

confidence: 99%

See 2 more Smart Citations

MiR-30a-5p promotes cholangiocarcinoma cell proliferation through targeting SOCS3

Zhang¹,

Wang²,

Li³

et al. 2020

J. Cancer

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“…Moreover, overexpression of NF-κB increased the expression of miR-30a-5p, inhibited the expression of its target gene WWP1, and promoted the malignant behavior of glioma cells. In contrast, WWP1 overexpression reduced miR-30a-5p expression by inhibiting NF-κB, thereby inhibiting the vicious behavior of glioma cells [102]. It can be seen that miR-30 is closely related to inflammation in antineoplastic drug CTX.…”

Section: Ventricular Remodeling and Mir-30 Familymentioning

confidence: 99%

The microRNA in ventricular remodeling: the miR-30 family

Zhang

Dong²,

Jia

et al. 2019

Bioscience Reports

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Ventricular remodeling (VR) is a complex pathological process of cardiomyocyte apoptosis, cardiac hypertrophy, and myocardial fibrosis, which is often caused by various cardiovascular diseases (CVDs) such as hypertension, acute myocardial infarction, heart failure (HF), etc. It is also an independent risk factor for a variety of CVDs, which will eventually to damage the heart function, promote cardiovascular events, and lead to an increase in mortality. MicroRNAs (miRNAs) can participate in a variety of CVDs through post-transcriptional regulation of target gene proteins. Among them, microRNA-30 (miR-30) is one of the most abundant miRNAs in the heart. In recent years, the study found that the miR-30 family can participate in VR through a variety of mechanisms, including autophagy, apoptosis, oxidative stress, and inflammation. VR is commonly found in ischemic heart disease (IHD), hypertensive heart disease (HHD), diabetic cardiomyopathy (DCM), antineoplastic drug cardiotoxicity (CTX), and other CVDs. Therefore, we will review the relevant mechanisms of the miR-30 in VR induced by various diseases.

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NEDD4 E3 ubiquitin ligases: Promising biomarkers and therapeutic targets for cancer

Tian

Chen

Peng

et al. 2023

Biochemical Pharmacology

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A positive feedback loop of miR-30a-5p-WWP1-NF-κB in the regulation of glioma development

Cited by 15 publications

References 16 publications

MiR-30a-5p promotes cholangiocarcinoma cell proliferation through targeting SOCS3

MiR-30a-5p promotes cholangiocarcinoma cell proliferation through targeting SOCS3

The microRNA in ventricular remodeling: the miR-30 family

NEDD4 E3 ubiquitin ligases: Promising biomarkers and therapeutic targets for cancer

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