A Polymorphism in the Serotonin Transporter Gene Regulatory Region and Frequency of Migraine Attacks

Kotani, Kazuhiko; Shimomura, Tokio; Shimomura, Fumiyo; Ikawa, Shiro; Nanba, Eiji

doi:10.1046/j.1526-4610.2002.02209.x

Cited by 50 publications

(63 citation statements)

References 11 publications

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“…While there is currently no clear evidence for 5-HTT polymorphisms being associated with migraine without aura [17,21,28,40], previous genetic studies pointed to a possible link between carriers of the short allele of the 5HTTLPR (5-HT gene linked polymorphic region) and migraine with aura [7,25]. So far, investigations which focused on a possible correlation between the 5-HTTLPR polymorphism and the availability of SERT-radioligands failed to show a simple genotypephenotype relationship [36].…”

Section: Discussionmentioning

confidence: 99%

Increased serotonin transporter availability in the brainstem of migraineurs

et al. 2007

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For decades, serotonin has been speculated to play a major role in migraine pathophysiology. The central serotonergic system is located in the raphe nuclei and the adjacent reticular formation in the brainstem. Recently, radioligands targeting the brain serotonin transport protein (SERT) have been developed. We used the highly specific SERT-radioligand (123)I-ADAM [2-((2-((dimethylamino) methyl)phenyl)thio)-5-iodophenylamine] to test the hypothesis of the mesopontine serotonergic system being involved in the pathophysiology of migraine. Nineteen migraine patients and 10 healthy, age- and sex-matched controls were enrolled. The neuroimaging study was performed interictally during the pain-free interval. Single Photon Emission Computed Tomography (SPECT)-images were coregistered with MRI-scans. Region of interest (ROI)-analysis revealed a highly significant increase of (123)I-ADAM uptake in the mesopontine brainstem of migraineurs (p < 0.001). In contrast, (123)IADAM uptake in the thalamus did not differ significantly between migraineurs and controls. Our study demonstrates for the first time a significant increase of brainstem SERT-availability in migraineurs, suggesting a dysregulation of the brainstem serotonergic system. It remains to be elucidated whether the altered SERT-availability is causally related to migraine pathophysiology or whether it reflects secondary pathophysiological mechanisms.

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Section: Discussionmentioning

confidence: 99%

Increased serotonin transporter availability in the brainstem of migraineurs

et al. 2007

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“…Twelve studies, which included a total of 1502 cases and 1958 controls, dealt with the association between 5-HTTLPR and migraine [12][13][14][31][32][33][34][35][36][37][38][39]. Four studies, involving 495 cases and 729 controls, examined the risk of 5-HTT VNTR in migraine [11,36,37,40].…”

Section: Eligible Studies and Study Characteristicsmentioning

confidence: 99%

“…Of studies investigating the 5-HTTLPR polymorphism, eight were performed on Caucasian populations [12][13][14]32,33,35,37,38] and four on Asian populations [31,34,36,39]. Nine studies examined patients with MA and MO [12,13,31,[33][34][35][37][38][39], one with MA alone [14] and two with MO alone [32,36]. In studies of 5-HTT VNTR polymorphism, three were carried out on Caucasians [11,37,40] and one was on Asians [36].…”

Section: Eligible Studies and Study Characteristicsmentioning

confidence: 99%

Association of 5-HTT gene polymorphisms with migraine: A systematic review and meta-analysis

Liu

Wang

et al. 2011

Journal of the Neurological Sciences

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“…Polymorphisms in the serotonin transporter gene (5HTTLPR) were identifi ed, with two polymorphic regions noted-one with a short-based pair region of 484 based pairs, and one with a long-based pair region of 428 polymorphisms [ 32 ]. Patients with migraine were compared with controls and could be classifi ed as having two short regions, two long regions, or a mixture.…”

Section: Serotonin Transporter Genementioning

confidence: 99%

Genetics of headache in children: Where are we headed?

Hershey

2008

Current Science Inc

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A history of headaches in a family is very frequently noted when evaluating a child for recurrent, episodic headaches. Oftentimes, these headaches have migraine features, although the family may deny a history of migraine. This positive family history implies an inherited or genetic basis as a component to the underlying pathophysiology of primary headaches. A variety of methodology has begun to elucidate this contribution, including historical observation, population-based studies of families and twins, gene polymorphism association studies, and specific gene identification for isolated migraine subtypes. This line of investigation should progress in the future to a better understanding of migraine and clarification of the diagnostic subtypes for a genotype-phenotype association.

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A Polymorphism in the Serotonin Transporter Gene Regulatory Region and Frequency of Migraine Attacks

Abstract: This polymorphism does not appear to be involved in a genetic predisposition to the disease but may affect the frequency of attacks in patients with migraine. These findings may contribute to our understanding of factors that influence the clinical severity of migraine.

Cited by 50 publications

References 11 publications

Increased serotonin transporter availability in the brainstem of migraineurs

Increased serotonin transporter availability in the brainstem of migraineurs

Association of 5-HTT gene polymorphisms with migraine: A systematic review and meta-analysis

Genetics of headache in children: Where are we headed?

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