A polygenetic risk score combined with environmental factors better predict susceptibility to hepatocellular carcinoma in Chinese population
Yuanlin Zou,
Jicun Zhu,
Caijuan Song
et al.
Abstract:AimsThis study aimed to investigate environmental factors and genetic variant loci associated with hepatocellular carcinoma (HCC) in Chinese population and construct a weighted genetic risk score (wGRS) and polygenic risk score (PRS).MethodsA case–control study was applied to confirm the single nucleotide polymorphisms (SNPs) and environmental variables linked to HCC in the Chinese population, which had been screened by meta‐analyses. wGRS and PRS were built in training sets and validation sets. Area under the… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.