Since the 1990s Brazilian foreign policy has become increasingly central to Latin American integration, to South—South relations, and to global governance, especially under the leadership of presidents Fernando Henrique Cardoso (1995—2002) and Luiz Inácio Lula da Silva (2003 to the present). This article argues that the making of Brazilian foreign policy since the mid-1990s has been marked by two major trends: pluralization of actors and the rise of presidentially led diplomacy. These two trends have promoted a gradual erosion of the influence of the highly professionalized and traditionally autonomous Foreign Ministry (Itamaraty). The article analyzes the role of global, regional, and domestic political factors in promoting this transformation, and examines the consequences for Brazil's foreign policy outputs.