A point-of-care chemiluminescence immunoassay for pepsinogen I enables large-scale community health screening

Detection of Carbohydrate Antigen 50 Based on a Novel Miniaturized Chemiluminescence Analyzer Enables Large-Scale Cancer Early Screening in Grassroots Community

“…A suitable incubation time for the antigen-antibody is beneficial to improve the overall reaction efficiency and save the assay time that is extremely critical for the large-scale screening of cancer ( Nayak et al, 2017 ; Liu et al, 2021 ). As shown in Figure 3D , the RLU increased within 20 min and hardly changed in 20–30 min, indicating a binding equilibrium between the antigen and antibody.…”

“…Large-scale screening in the grassroots communities requires not only miniature and portable analyzers but also intelligent and integrated operating systems. Hence, the miniaturized CLIA analyzer with a fully automated operation system and shortened analysis time has been urgently demanded for the rapid POC cancer screening ( Poschenrieder et al, 2019 ; Xiao and Xu, 2020 ; Liu et al, 2021 ).…”

Painless and sensitive pepsinogen I detection: an electrochemical immunosensor based on rhombic dodecahedral Cu3Pt and MoS2 NFs

“…Gastroscopy is the gold standard for detecting gastric disorders, but the high cost and invasive nature of the procedure make it unappealing to patients. 17 Electrochemical methods have attracted a great deal of attention due to their good physicochemical properties and the advantages of simplicity of operation, high population acceptance and reproducibility. 18,19 Moreover, there are no published studies on the detection of PG in serum via electrochemical methods.…”