A placebo‐controlled multi‐centred evaluation of an anaesthetic gel (Oraqix<sup>®</sup>) for periodontal therapy

Donaldson, David; Gelskey, Shirley C.; Landry, R G; Matthews, David; Sandhu, Harman Singh

doi:10.1034/j.1600-051x.2003.00017.x

Cited by 47 publications

(81 citation statements)

References 8 publications

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“…A number of studies evaluating topical intrapocket anesthesia have used Oraqix, which was developed for periodontal use and has demonstrated satisfactory effectiveness for subgingival SRP (3,(7)(8)(9). Oraqix was found to be safe and effective at doses ranging from 3.5 g (2.5 mL) (15) to 8.5 g (6 mL) (16) per session of subgingival SRP.…”

Section: Discussionmentioning

confidence: 99%

“…This product has proven to be a reliable alternative to injectable anesthesia (7)(8)(9). A eutectic mixture denominated EMLA ® has the same composition as Oraqix, but is offered at a lower cost.…”

Section: Introductionmentioning

confidence: 99%

“…While injectable anesthetics are effective in controlling pain, many patients report fear of the needle, long-lasting effects and the prolonged numbness of adjacent tissues, such as the lips and tongue (3)(4)(5). The need for painless, noninvasive, fast-acting anesthetics with effectiveness only during the procedure has led to the investigation of the use of substances with topical application during SRP (3,(6)(7)(8)(9)(10)(11) and periodontal maintenance (12). It has recently been demonstrated that the use of a topical anesthetic does not compromise subgingival treatment and offers similar benefits to pocket probing and clinical attachment gain to an injectable anesthetic (13).…”

Section: Introductionmentioning

confidence: 99%

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Topical Intrapocket Anesthesia During Scaling and Root Planing: a Randomized Clinical Trial

et al. 2015

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Although the use of injectable anesthesia prior to subgingival scaling and root planing (SRP) reduces pain, many patients report fear and prolonged numbness of adjacent tissues. The aim of the present study was to compare the effects of a eutectic mixture containing 25 mg/g of lidocaine and 25 mg/g of prilocaine, injectable 2% lidocaine, topical 2% benzocaine and a placebo substance on reducing pain during SRP. In this randomized, split-mouth, masked clinical trial, thirty-two patients presenting more than two teeth with probing depth and clinical attachment level ≥5 mm in at least 4 sextants were randomly allocated to four groups: EMLA ® ; injectable 2% lidocaine; topical 2% benzocaine and placebo. Pain and discomfort were measured using a visual analogue scale (VAS) and verbal scale (VS). Repeated-measures analysis of variance and Poisson regression were used for analysis. Patient satisfaction with the anesthesia was determined at the end of each treatment session. VAS and VS scores did not differ between injectable 2% lidocaine and EMLA (p>0.05) and both substances showed significantly better pain control compared to 2% benzocaine and placebo (p<0.05). 93.7% and 81.2% of the individuals were satisfied with the injectable anesthetic and EMLA, respectively (p=0.158). Dissatisfaction with benzocaine and placebo was approximately 10 times greater than injectable anesthesia (p=0.001). In conclusion, EMLA showed an equivalent effect on pain control when compared to the injectable anesthesia and performed better than 2% benzocaine in SRP. Thus, EMLA is a viable anesthetic option during scaling and root planning, despite the frequent need for second application.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Topical Intrapocket Anesthesia During Scaling and Root Planing: a Randomized Clinical Trial

et al. 2015

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“…The use of topical anesthesia for SRP has been shown to be superior to placebo (Magnusson et al, 2004, Mayor-Subirana et al, 2013. Even so, there are reports of the occurrence of pain with the need for infiltrative terminal anesthesia after topical anesthetic application (Jeffcoat et al, 2001, Donaldson et al, 2003, Magnusson et al, 2003.Variations in the studies design, such as in the sample selection, patient randomization, operator experience, level of periodontal involvement, type of scales used to assess pain can influence the results (Donaldson et al, 2003). Different shaped hand and power-driven instruments may also be a factor that influences pain intensity (Braun et al, 2007).…”

mentioning

confidence: 99%

Intra‐pocket anaesthesia and pain during probing, scaling and root planing: a systematic review and meta‐analysis

Wambier

Geus

Chibinski

et al. 2016

J Clinic Periodontology

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“…Lidocaine jelly (2%) preparations have been reported to be beneficial in upper airway, 2,3 dental, 4 urogenital, 5 and gastrointestinal procedures. 6 The use of lidocaine topical anesthetic as a single agent for ocular procedures has been reviewed in several studies.…”

mentioning

confidence: 99%

A novel lidocaine hydrochloride ophthalmic gel for topical ocular anesthesia

Busbee¹

2010

LRA

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Topical anesthetics play an important role in the practice of ophthalmology, both for procedures in the office and in the operating room. The need for safe, long-acting topical ocular anesthetic agents is ongoing, and has been highlighted by the increase of intravitreal administration of pharmacologic agents. Current practices for ocular anesthesia include subconjunctival injection of 2% aqueous lidocaine, topical 2% lidocaine drops and topical 0.5% tetracaine. Tetracaine is not yet FDA approved, and is associated with corneal epithelial toxicity and delayed epithelial healing after multiple administrations. Lidocaine jelly (2%) preparations have been reported to be beneficial in several systemic procedures, including those of the upper airway, dental, urogenital, and gastrointestinal. It has been theorized, and recent studies support the idea, that gel formulations of lidocaine may enhance anesthetic effect, and therefore be superior to anesthetic solutions for topical cataract surgery. The viscous nature of gel formulations is thought to lengthen contact time, resulting in better anesthesia at lower drug concentrations. Furthermore, several studies suggest that lidocaine is bactericidal and bacteriostatic, and may have a supplementary role in preventing and treating surgical site infections. Akten™, lidocaine 3.5% gel (Akorn, Buffalo Grove, IIlinois) was FDA approved for all ophthalmic procedures in October 2008. This gel is a preservative-free, lidocaine-based anesthetic gel consisting of 35 mg/mL of lidocaine hydrochloride. We describe the properties, including chemical structure, indications, evidence of support, use, adverse effects, and precautions, which we believe enable Akten to provide superior anesthesia, while minimizing side effects.

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A placebo‐controlled multi‐centred evaluation of an anaesthetic gel (Oraqix^®) for periodontal therapy

Abstract: The VAS pain scores showed that the anaesthetic gel 5% was statistically more effective than the placebo in reducing pain during periodontal debridement.

Cited by 47 publications

References 8 publications

Topical Intrapocket Anesthesia During Scaling and Root Planing: a Randomized Clinical Trial

Topical Intrapocket Anesthesia During Scaling and Root Planing: a Randomized Clinical Trial

Intra‐pocket anaesthesia and pain during probing, scaling and root planing: a systematic review and meta‐analysis

A novel lidocaine hydrochloride ophthalmic gel for topical ocular anesthesia

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A placebo‐controlled multi‐centred evaluation of an anaesthetic gel (Oraqix®) for periodontal therapy

Abstract: The VAS pain scores showed that the anaesthetic gel 5% was statistically more effective than the placebo in reducing pain during periodontal debridement.

Cited by 47 publications

References 8 publications

Topical Intrapocket Anesthesia During Scaling and Root Planing: a Randomized Clinical Trial

Topical Intrapocket Anesthesia During Scaling and Root Planing: a Randomized Clinical Trial

Intra‐pocket anaesthesia and pain during probing, scaling and root planing: a systematic review and meta‐analysis

A novel lidocaine hydrochloride ophthalmic gel for topical ocular anesthesia

Contact Info

Product

Resources

About

A placebo‐controlled multi‐centred evaluation of an anaesthetic gel (Oraqix^®) for periodontal therapy