A pilot validation in 10 European Union Member States of a point prevalence survey of healthcare-associated infections and antimicrobial use in acute hospitals in Europe, 2011

Reilly, Jacqui; Price, Lesley; Godwin, Jon; Cairns, Shona; Hopkins, Susan; Cookson, Barry; Malcolm, William; Hughes, G.; Lyytikäinen, Outi; Coignard, B.; Hansen, Sonja; Suetens, Carl; study, Collective National Participants in the ECDC pilot validation

doi:10.2807/1560-7917.es2015.20.8.21045

Cited by 16 publications

(14 citation statements)

References 15 publications

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“…During the SNHPS, we did not have resources needed for the concurrent validation of data collection methods within the European point prevalence survey of healthcare-associated infections and antimicrobial use in Europe in 2011 validation study performed in 10 EU Member States in 20 acute hospitals. The sensitivity of 83% (95% CI: 79%–87%) and specificity of 98% (95% CI: 98%-99%) were found for HAIs ( 6 ). The level of agreement between the primary survey data collection and validation of results were very good for HAIs overall (Cohen’s κappa (κ): 0.81), and across all the types of HAIs (the range: from 0.83 for bloodstream infections to 1.00 for lower respiratory tract infections).…”

Section: Discussionmentioning

confidence: 99%

The prevalence of and risk factors for healthcare-associated infections in Slovenia: results of the second national survey

Klavs

Kolman

Zupanc

et al. 2016

Slovenian Journal of Public Health

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IntroductionIn the second Slovenian national healthcare-associated infections (HAIs) prevalence survey, conducted within the European point prevalence survey of HAIs and antimicrobial use in acute-care hospitals, we estimated the prevalence of all types of HAIs and identified risk factors.MethodsPatients from acute-care hospitals were enrolled into a one-day cross-sectional study in October 2011. Descriptive analyses were performed to describe the characteristics of patients, their exposure to invasive procedures and the prevalence of different types of HAIs. Univariate and multivariate analyses of association of having at least one HAI with possible risk factors were performed to identify risk factors.ResultsAmong 5628 patients, 3.8% had at least one HAI and additional 2.6% were still being treated for HAIs on the day of the survey; the prevalence of HAIs was 6.4%. The prevalence of urinary tract infections was the highest (1.4%), followed by pneumoniae (1.3%) and surgical site infections (1.2%). In intensive care units (ICUs), the prevalence of patients with at least one HAI was 35.7%. Risk factors for HAIs included central vascular catheter (adjusted odds ratio (aOR) 4.0; 95% confidence intervals (CI): 2.9-5.7), peripheral vascular catheter (aOR 2.0; 95% CI: 1.5-2.6), intubation (aOR 2.3; 95% CI: 1.4-3.5) and rapidly fatal underlying condition (aOR 2.1; 95% CI: 1.4-3.3).ConclusionsThe prevalence of HAIs in Slovenian acute-care hospitals in 2011 was substantial, especially in ICUs. HAIs prevention and control is an important public health priority. National surveillance of HAIs in ICUs should be developed to support evidence-based prevention and control.

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Section: Discussionmentioning

confidence: 99%

The prevalence of and risk factors for healthcare-associated infections in Slovenia: results of the second national survey

Klavs

Kolman

Zupanc

et al. 2016

Slovenian Journal of Public Health

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“…There were striking differences in antimicrobial prescription patterns between Indian and European centers. European centers used narrow spectrum antimicrobials consisting mainly of penicillins, sulphonamides, aminoglycosides and other betalactams, while in the Indian centers high-end reserve antibiotics like piperacillin-tazobactam and carbapenems were commonly used [7][8][9].…”

Section: Discussionmentioning

confidence: 99%

A point prevalence surveillance study from pediatric and neonatal specialty hospitals in India

Singh

Jose

Versporten

et al. 2015

J Pediatr Infect Dis

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Point prevalence surveys (PPS) have been used to document antimicrobial use in healthcare organizations. Antimicrobial resistance is a global concern, more so for developing countries like India, where the burden of antimicrobial resistance and infectious diseases are very high. A web based PPS developed by University of Antwerp, Belgium for the Antibiotic Resistance and Prescribing in European Children (ARPEC) project was used to enter data from pediatric and neonatal wards and intensive care units (ICU) from 8 centers across India. All patients who were receiving systemic antibacterial treatments on the day of the survey inclusive of antibacterial prophylaxis for surgery were included. 195 patients were surveyed across India: 105 (54%) medical and 90 (46%) surgical. 192 (98%) patients received multiple antimicrobials out of which 187 (95%) were given parenterally. Empirical antimicrobials were prescribed in 138 (71%) patients and targeted therapy in 57 (29%). The commonest infections for which antimicrobials were prescribed were healthcare associated infections 180 (41.76%) followed by surgical prophylaxis 90 (21%) and community acquired infections 84 (18%). Antimicrobials usage was maximal in ICUs. More than a single dose (5.6%) for more than a day (86.7%) was used for surgical prophylaxis. The Web based PPS suggests widespread antibiotic usage among pediatric and neonatal patients in selected tertiary Indian hospitals and underscores the need for antibiotic stewardship in order to promote rational and evidence based practice to limit the emergence of antibiotic resistant microbes.

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“…The extrapolation of the RMCR results to the 1655 eligible patients (UMCL patients included into the SNHPS without neonates and duplicates) was performed. We used the same approach as described in Reilly et al ( 11 ). The positive predictive value (PPV) and negative predictive value (NPV) were calculated from combined RMCR and SNHPS datasets.…”

Section: Methodsmentioning

confidence: 99%

“…In order to contribute to the accuracy of results of future surveys, sensitivity and specificity of methods used should be determined regularly ( 9 , 10 ). Recently, the results of the ECDC pilot validation of the EUPPS in 10 European Union (EU) Member States conducted in 2011 were published ( 11 ). The overall sensitivity and specificity of the method used for ascertainment of HAIs were estimated to be 83% and 98%, respectively.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity and specificity of the method used for ascertainment of healthcare-associated infections in the second Slovenian national prevalence survey

Serdt

Zupanc

Korošec

et al. 2016

Slovenian Journal of Public Health

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IntroductionThe second Slovenian national healthcare-associated infections (HAIs) prevalence survey (SNHPS) was conducted in acute-care hospitals in 2011. The objective was to assess the sensitivity and specificity of the method used for the ascertainment of six types of HAIs (bloodstream infections, catheter-associated infections, lower respiratory tract infections, pneumoniae, surgical site infections, and urinary tract infections) in the University Medical Centre Ljubljana (UMCL).MethodsA cross-sectional study was conducted in patients surveyed in the SNHPS in the UMCL using a retrospective medical chart review (RMCR) and European HAIs surveillance definitions. Sensitivity and specificity of the method used in the SNHPS using RMCR as a reference was computed for ascertainment of patients with any of the six selected types of HAIs and for individual types of HAIs. Agreement between the SNHPS and RMCR results was analyzed using Cohen’s kappa coefficient.Results1474 of 1742 (84.6%) patients surveyed in the SNHPS were included in RMCR. The sensitivity of the SNHPS method for detecting any of six HAIs was 90% (95% confidence interval (CI): 81%-95%) and specificity 99% (95% CI: 98%-99%). The sensitivity by type of HAI ranged from 63% (lower respiratory tract infections) to 92% (bloodstream infections). Specificity was at least 99% for all types of HAIs. Agreement between the two data collection approaches for HAIs overall was very good (κ=0.83).ConclusionsThe overall sensitivity of SNHPS collection method for ascertaining HAIs overall was high and the specificity was very high. This suggests that the estimated prevalence of HAIs in the SNHPS was credible.

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A pilot validation in 10 European Union Member States of a point prevalence survey of healthcare-associated infections and antimicrobial use in acute hospitals in Europe, 2011

Cited by 16 publications

References 15 publications

The prevalence of and risk factors for healthcare-associated infections in Slovenia: results of the second national survey

The prevalence of and risk factors for healthcare-associated infections in Slovenia: results of the second national survey

A point prevalence surveillance study from pediatric and neonatal specialty hospitals in India

Sensitivity and specificity of the method used for ascertainment of healthcare-associated infections in the second Slovenian national prevalence survey

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