A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel ( Anguilla anguilla )

Brinkmann, Markus; Freese, Marko; Pohlmann, Jan‐Dag; Kammann, Ulrike; Preuß, Thomas G.; Buchinger, Sebastian; Reifferscheid, Georg; Beiermeister, Anne; Hanel, Reinhold; Hollert, Henner

doi:10.1016/j.scitotenv.2015.07.046

Cited by 19 publications

(14 citation statements)

References 49 publications

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“…In addition, temperature might alter the molecular structure of the branchial epithelium, modifying its permeability to compounds (Crockett and Hazel, 1995). Some recent PBTK models have described the effect of temperature on ventilation in fish (Péry et al 2014;Brinkmann et al 2014;Brinkmann et al 2015;Grech et al 2019). Results of the PBTK model developed by showed the importance of the branchial pathway to plot PFOS TK.…”

Section: Discussionmentioning

confidence: 99%

Temperature effect on perfluorooctane sulfonate toxicokinetics in rainbow trout (Oncorhynchus mykiss): Exploration via a physiologically based toxicokinetic model

et al. 2020

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Salmonids are poikilotherms which means that their internal temperature varies with that of water. Water temperature thus controls many of their lifecycle processes and physiological functions, which could influence the mechanisms of absorption, distribution, metabolism and excretion (ADME) of many substances, including perfluorinated alkyl substances (PFAAs). However, the processes governing the fate of PFAAs are still poorly understood in fish. Here we developed a physiologically based toxicokinetic (PBTK) model for rainbow trout (Oncorhynchus mykiss) to study changes in physiological functions and PFAA ADME at different temperatures. The model was calibrated using experimental data from dietary exposure to perfluorooctane sulfonate at 7°C and 19°C. Predictions of PFOS concentrations were globally satisfactory at both temperatures, when accounting for the influence of temperature on growth, ventilation rate, cardiac output, clearances, and absorption rates. Accounting for the influence of temperature on tissue-plasma partition coefficients significantly improved predicted inorgan PFOS concentrations.

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Section: Discussionmentioning

confidence: 99%

Temperature effect on perfluorooctane sulfonate toxicokinetics in rainbow trout (Oncorhynchus mykiss): Exploration via a physiologically based toxicokinetic model

et al. 2020

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“…To swim towards the spawning ground and reproduce, silver eels need sufficient energy reserves. Because lipids are mainly stored in the muscle tissues (Boëtius and Boëtius, 1985;Dave et al, 1976) which constitute a large part of the bodyweight (Brinkmann et al, 2015) and since our muscular sampling area reflects the total muscular lipid level (Pohlmann et al, 2019), the measures of lipid content in muscles of our study provide a representative proxy for total energy stores. Several experiments and modelling studies suggest that the migration may consume 60-65% of the total lipid content (or the 12-13% of the body weight that it represents), while maturation requires an additional 40% (8% body weight, van den Thillart et al, 2007).…”

Section: Quality Of Eelsmentioning

confidence: 99%

“…iii) The contaminant load in body tissues. Contaminants such as lipophilic persistent organic pollutants (POPs) and non-lipophilic trace elements (TEs) bioaccumulate in the lipid, muscles and organs (for example : Brinkmann et al, 2015;ICES, 2016;Zacs et al, 2018). During migration, the contaminants are remobilised and directed towards developing organs like gonads and eggs (Freese et al, 2019;Sühring et al, 2015Sühring et al, , 2016b.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the quality of European silver eels and tentative approach to trace the origin of contaminants – A European overview

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et al. 2020

Science of The Total Environment

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Highlights • Among 482 eels, 66% were impacted by A. crassus and 27% showed evidence of past infection. • Among 169 eels, organic and inorganic contaminants showed high prevalence. • Variability in eel quality at the European scale was mainly driven by organic pollutants. • According a risk index, eels from Scheldt, Warwickshire and Frémur ranked lowest risk. • Eel quality risks were positively correlated with a remote sensing anthropization index.

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“…Currently, it is sought for practical implementations of these findings at least for the assessment of dredged materials. In addition to the experimental work conducted within the project, computational models were developed, which will be highly valuable to derive scientifically sound sediment quality standards (Brinkmann et al [ 174 , 175 ]).…”

Section: Scientific Support For Dioxin- and Wfd-related Eu-directivesmentioning

confidence: 99%

Dioxin in the Elbe river basin: policy and science under the water framework directive 2000–2015 and toward 2021

et al. 2016

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A critical review of the last 25 years of dioxin policy in the Elbe river catchment is presented along seven main theses of the River Basin Community (RBC)-Elbe background document “Pollutants” for the Management Plan 2016–2021. In this period, polychlorinated dibenzodioxins/-furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) will play a major role: (i) as new priority substances for which environmental quality standards (EQSs) need to be derived (Directive 2013/39/EC); (ii) in the search for innovative solutions in sediment remediation (i.e., respecting the influence of mechanical processes; Flood Risk Directive 2007/60/EC); and (iii) as indicators at the land–sea interface (Marine Strategy Framework Directive 2008/56/EC). In the Elbe river catchment, aspects of policy and science are closely connected, which became particularly obvious in a classic example of dioxin hot spot contamination, the case of the Spittelwasser creek. Here, the “source-first principle” of the first cycle of the European Water Framework Directive (WFD) had to be confirmed in a controversy on the dioxin hot spots with Saxony-Anhalt’s Agency for Contaminated Sites (LAF). At the Spittelwasser site, the move from “inside the creek” to “along the river banks” goes parallel to a general paradigm shift in retrospective risk assessment frameworks and remediation techniques for organic chemicals (Ortega-Calvo et al. 2015). With respect to dioxin, large-scale stabilization applying activated carbon additions is particularly promising. Another important aspect is the assessment of the ecotoxicology of dioxins and dl- PCBs in context of sediment mobility and flood risk assessment, which has been studied in the project framework FloodSearch. Currently, the quality goals of the WFD to reach a “good chemical status” are not met in many catchment areas because substances such as mercury do and others probably will (PCDD/Fs and dl-PCB) exceed biota-EQS values catchment area-wide. So far, relating biota-EQS values to sediment-EQSs is not possible. To overcome these limitations, the DioRAMA project was initiated, which has led to improved approaches for the assessment of dioxin-contaminated sediment using in vitro bioassays and to a robust dataset on the interrelation between dioxins and dioxin-like compounds in sediments and biota.Electronic supplementary materialThe online version of this article (doi:10.1186/s12302-016-0075-8) contains supplementary material, which is available to authorized users.

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A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel ( Anguilla anguilla )

Cited by 19 publications

References 49 publications

Temperature effect on perfluorooctane sulfonate toxicokinetics in rainbow trout (Oncorhynchus mykiss): Exploration via a physiologically based toxicokinetic model

Temperature effect on perfluorooctane sulfonate toxicokinetics in rainbow trout (Oncorhynchus mykiss): Exploration via a physiologically based toxicokinetic model

Assessment of the quality of European silver eels and tentative approach to trace the origin of contaminants – A European overview

Dioxin in the Elbe river basin: policy and science under the water framework directive 2000–2015 and toward 2021

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