A Phase II Study with Antioxidants, Both in the Diet and Supplemented, Pharmaconutritional Support, Progestagen, and Anti-Cyclooxygenase-2 Showing Efficacy and Safety in Patients with Cancer-Related Anorexia/Cachexia and Oxidative Stress

Mantovani, Giovanni; Macciò, Antonio; Madeddu, Clelia; Gramignano, Giulia; Lusso, Maria Rita; Serpe, Roberto; Massa, Elena; Astara, Giorgio; Deiana, Laura

doi:10.1158/1055-9965.epi-05-0538

Cited by 140 publications

(106 citation statements)

References 27 publications

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“…Intervention should include dietary counselling, nutritional and vitamin supplementation, exercise concordant with the patient's physical condition, anti-inflammatory agents, anabolic drugs and the most adequate symptom managements. In the context of such combined approaches, one of the most intriguing ones was an open phase II trial published by our group (Mantovani et al, 2006) which aimed to test the safety and efficacy of an integrated treatment based on diet, pharmaconutritional support administered orally, and drugs in a population of cachectic patients with advanced cancer at different sites, including also a significant percentage of EOC patients. The treatment consisted of diet with high polyphenols content (400 mg), antioxidant treatment (300 mg/day alpha lipoic acid+2.7 g/day carbocysteine lysine salt+400 mg/day vitamin E+30,000 IU/day vitamin A+500 mg/day vitamin C), and pharmaconutritional support enriched with two cans per day (n−3)-PUFA (eicosapentaenoic acid and docosahexaenoic acid), 500 mg/day MPA and 200 mg/day selective cyclooxygenase-2 inhibitor celecoxib.…”

Section: Inflammation and Possible Therapeutic Implicationsmentioning

confidence: 99%

Inflammation and Ovarian Cancer

Macci¹,

Madeddu²

2012

Ovarian Cancer - Basic Science Perspective

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Section: Inflammation and Possible Therapeutic Implicationsmentioning

confidence: 99%

Inflammation and Ovarian Cancer

Macci¹,

Madeddu²

2012

Ovarian Cancer - Basic Science Perspective

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“…Suplementos nutricionais que contêm AGPIs n-3 são benéficos para reduzir a perda de peso associada à caquexia/câncer em pacientes com neoplasias em estado avançado. Ensaios clínicos sugerem que AGPIs n-3 podem estabilizar a perda de peso ou levar ao ganho de peso em pacientes com câncer avançado com caquexia 16,29 . Esta perda de peso corporal em indivíduos caquéticos está associada à presença de fator indutor de proteólise (PIF) secretado pelo tumor 27 .…”

Section: Pesounclassified

Exercício de força associado a óleo de peixe reduzem massa tumoral e caquexia em ratos

Gomes

Kryczyk

Minuzzi

et al. 2014

Rev Bras Med Esporte

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RESUMOObjetivo: Investigar o efeito do treinamento de salto associado à suplementação com óleo de peixe (1g/kg peso corporal/dia) em ratos portadores do tumor de Walker 256, sobre parâmetros bioquímicos de caquexia e crescimento tumoral. Métodos: Oitenta Ratos foram divididos em sedentário sem ou com tumor (S ou SW), exercitado (EX ou EXW), suplementado com óleo de peixe (SO ou SWO) e suplementado e exercitado (EXO ou EXWO). Sessões de treinamento de salto consistiram de 10 séries com duração de 30 segundos e intervalo de 1 minuto entre cada série. Após seis semanas de treinamento, células do tumor de Walker 256 foram inoculadas e após 15 dias os animais foram mortos. Resultados: O peso médio do tumor no grupo SW foi de 25,32 g, p<0,05 vs. ao dos SWO, EXW e EXWO (~11 g). O grupo SW apresentou hipoglicemia, hiperlactatemia, hipertriacilglicerolemia e perda de peso (-7,52±3,19g) (-7.52 ± 3.19g) grupo SW presento hipoglucemia, hiperlactatemia y hipertriacilglicerolemia y reducción de peso corporal (-7,52 ± 3,19 ABSTRACT Objective: To investigate the effect of jump training associated with fish oil (FO) supplementation (1g/Kg bodyweight/day) on biochemical parameters of cachexia and tumor growth in Walker 256 tumor-bearing rats. Methods: Eighty rats were divided into sedentary non-and tumor-bearing (S and SW), exercised (EX and EXW), FO supplemented (SO and SWO), and both supplemented and exercised (EXW and EXWO). Jump training sessions consisted of 10 series of 30 seconds each, followed by 1 minute of rest. After six weeks of jump training, ascitic cells from Walker 256 tumor bearing-rat were inoculated, and after 15 days, all the animals were sacrificed. Results: The tumor mass in the SW group was 25.32 g, p<0.05 vs the SWO, EXW and EXWO groups (~11 g). The SW group presented hypoglycemia, hyperlactacidemia and hypertriacylglycerolemia and a reduction in body weight Métodos: Ochenta ratas fueron divididas en sedentarias sin y con tumor (S o SW), ejercitadas (EX o EXW), suplementadas con aceite de pescado (SO o SWO) y ejercitadas y suplementadas de forma simultánea (EXO o EXWO). Las sesiones de entrenamiento de salto consistieron en g), lo que caracteriza el estado caquéctico. La suplementación con aceite de pescado (SWO), el ejercicio (EXW) y la asociación de ambos (EXWO) impidieron la instalación de la caquexia (p < 0,05 vs. SW). En el grupo SWO, EXW e sus asociaciones (EXWO) promovieron aumento de peso (p < 0,05 vs. SW), pero inferior al de la suplementación aislada (p < 0,05 vs. SWO). La proliferación in vitro de las células tumorales fue menor en el grupo SWO (p < 0,05 vs. SW) y el ejercicio la redujo todavía más (p < 0,05 vs. SW e SWO), no habiendo incremento cuando se asociaran ambas las terapias. La lipoperoxidación fue mayor en los grupos SWO, EXW, EXWO con respecto al grupo S (p < 0,05). La expresión de INTRODUÇÃOAlguns pacientes com câncer podem desenvolver a síndrome metabólica complexa denominada caquexia, caracterizada por progressiva perda de peso, anorexia, astenia, anemia, náusea crônica, imu...

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“…Besides an adequate intake of energy-building substrates, an optimum supply of micronutrients is also required (27)(28)(29)(30)147). Therefore, in recent years the administration of micronutrient supplements to cancer patients has gained growing interest (31, [47][48][49][50][51]53,54,56). From the dietetic-therapeutic point of view, such substances can perform the following functions (148): i) compensation of a nutrient deficit induced by the cancer disease itself and/ or the antineoplastic therapy with the aim of improving the patient's nutritional status; and ii) specific supplementation for dietetic-therapeutic purposes aiming less at the supply of nutrients, rather at taking a beneficial influence on the course of the disease.…”

Section: Tumor-associated Deficit Of Micronutrients -Pathophysiologicmentioning

confidence: 99%

“…Against this background it is evident that a supportive nutrition therapy should be an integral part of cancer care (44)(45)(46). In addition to a sufficient supply of energy substrates, vitamins and minerals as well as long-chain ˆ-3 fatty acids are becoming more and more interesting (31, [47][48][49][50][51][52][53][54][55][56], although the therapeutic benefit of such supplements is the subject of a controversial discussion, especially in respect ONCOLOGY REPORTS 24: 815-828, 2010 of supplements with high concentrations of antioxidants like the vitamins C and E and the trace element selenium (57)(58)(59)(60)(61)(62)(63)(64)(65)(66).…”

Section: Introductionmentioning

confidence: 99%

Nutrition in oncology: the case of micronutrients (Review)

Ströhle¹

2010

Oncol Rep

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Abstract. In the course of cancer disease, many oncological patients develop tumor-associated malnutrition characterized by an insufficient supply of macro-and micronutrients. The inadequate nutritional status and the cancer anorexia-cachexia syndrome related to it are clinically relevant, as the response to antineoplastic measures, such as radiation and chemotherapy, is diminished, their side effects aggravated and the patient's quality of life and prognosis negatively affected. Therefore, the supportive nutrition care of oncological patients is of central importance. In this context, vitamins, minerals and long-chain ˆ-3 fatty acids are becoming more and more relevant in oncology although the benefit of such supplements is discussed controversially. Starting from a description of the etiopathogenesis and the pathophysiological consequences of cancer-associated malnutrition, the present study provides an overview of the importance of micronutrients for oncological patients. In the case of reduced food intake and/or inappropriate food choice the use of a multi-vitaminmultimineral supplement administered in physiological doses, i.e. nutrient quantities approximately corresponding to the recommended daily allowances, can be generally recommended. However, to enhance postoperative wound healing, it seems that cancer patients require higher amounts of micronutrients than healthy individuals. Because vitamin D deficiency is highly prevalent in oncological patients, improvement of vitamin D status is of special interest.

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A Phase II Study with Antioxidants, Both in the Diet and Supplemented, Pharmaconutritional Support, Progestagen, and Anti-Cyclooxygenase-2 Showing Efficacy and Safety in Patients with Cancer-Related Anorexia/Cachexia and Oxidative Stress

Abstract: Purpose: To test the efficacy and safety of an integrated treatment based on a pharmaconutritional support, antioxidants, and drugs, all given orally, in a population of advanced cancer patients with cancer-related anorexia/ cachexia and oxidative stress.

Cited by 140 publications

References 27 publications

Inflammation and Ovarian Cancer

Inflammation and Ovarian Cancer

Exercício de força associado a óleo de peixe reduzem massa tumoral e caquexia em ratos

Nutrition in oncology: the case of micronutrients (Review)

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