A phase II study of mitomycin-C and S-1 as third-line chemotherapy in patients with advanced colorectal cancer

Kim, Jung Han; Kim, Hyeong Su; Choi, Dae Ro; Jang, Geundoo; Kwon, Jung Hye; Kim, Ho Young; Jung, Joo Young; Kim, Hyo Jung; Song, Hun Ho; Shin, Yun Ho; Jung, So Young; Kim, Byung Chun; Zang, Dae Young

doi:10.3892/ol.2011.367

Cited by 4 publications

(5 citation statements)

References 16 publications

(15 reference statements)

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“…It is mostly known as a mitostatic agent used for treatment of cancer and other diseases associ ated with redundant cell proliferation (Volpato and Phillips, 2007;Kim et al, 2011;Anjos et al, 2012;Wu et al, 2013). Most papers are concerned with antibi otic toxicity and optimization of its therapeutic effect for cancer patients (Hlavin et al, 2010;Wang et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

HeLa cell response to mitomycin C. I. cell division

Petrov

2014

Cell Tiss. Biol.

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The effect of mitomycin C (10 µg/mL) on HeLa M cells was studied using light microscopy, time lapse imaging, and digital image analysis. It was shown that after 2 h of being in contact with mitomycin, the cells could be divided into two groups: M I, functional cells surviving after division but not entering mitosis, and M II, cells entering mitosis but incapable to complete it, which results in their death. It is known that mitomycin C, being located in the DNA minor groove, specifically blocks DNA replication. According to the standard hypothesis of transcription bubble formation, it should inhibit RNA synthesis. However, the increase in the cell and nucleolus area during the M I cell growth suggests that RNA and protein synthesis are not blocked. I conclude that these findings confirm my hypothesis of RNA synthesis in the main DNA groove without its local melting (Petrov, 2006).

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Section: Discussionmentioning

confidence: 99%

HeLa cell response to mitomycin C. I. cell division

Petrov

2014

Cell Tiss. Biol.

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“…[72] For example, transition metals may be used to enhance the binding of hydrogen within the silica, and the size of the cation may be modified to alter the pore space and the free pore space. [73,74] Silica as a porous material has been investigated for its potential use to store hydrogen. Early studies concentrated on hydrogen encapsulation in silica at low and high temperatures and pressures.…”

Section: Silicamentioning

confidence: 99%

“…Similarly, exchangeable cations make it possible to modify certain properties of the silica material [72] . For example, transition metals may be used to enhance the binding of hydrogen within the silica, and the size of the cation may be modified to alter the pore space and the free pore space [73,74] . Silica as a porous material has been investigated for its potential use to store hydrogen.…”

Section: Metal‐doped Materials For Hydrogen Storagementioning

confidence: 99%

Potential Applications of Metal‐Doped Nanomaterials for Enhancing Solid‐State Hydrogen Storage

Abdulkadir,

Teh,

Rahman Khan

et al. 2024

ChemistrySelect

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Hydrogen energy is the primary replacement for fossil fuels in the future because of its advantages in terms of efficiency, cost‐effectiveness, and environmental friendliness. The fundamental issue with hydrogen, however, arises from its exceedingly low volumetric density; thus, developing efficient storage methods is critical to achieving a sustainable hydrogen economy. Hydrogen storage has demonstrated tremendous potential as a possible alternative for effective large‐scale storage. Due to their low cost, and high volumetric and gravimetric capacities, metal hydride‐based storage is considered the most prospective solid‐state storage material. Their low storage capacity nevertheless restricts their application effectively. Hence, the need to enhance the storage capacity by doping active metals becomes an interesting study area. With considerable success, metals, particularly transition metals, have been used to modify hydrides to improve their storage capacities. Owing to their strong and superior performance, active metals have demonstrated tremendous potential in increasing the performance of storage materials. This review critically examined recent developments in enhancing hydrogen storage characteristics through the incorporation of active metals. The preparation techniques for metal infiltration through different techniques, such as impregnation, ball/mechanical milling, and reflux were reported. The review describes significant advances in hydrogen storage characteristics due to metal doping and offers perspective recommendations for future research.

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“…With increasing Zn content, these samples revealed a reduction in pore volume and surface area, but a rise in d-spacing in their XRD patterns, suggesting Zn integration into the structure. Similarly, Kim et al [122] studied the influence of MCM-41 nanoconfinement technology on the thermal breakdown of metal borohydrides. The researchers reported that the melting and decomposition temperatures of metal borohydrides nanoconfined in the MCM-41 mesopores were affected.…”

Section: Mcm-41mentioning

confidence: 99%

“…More so, recent research and findings have shown that the confinement of hydrides in porous material at the nanoscale range can affect hydrides′ hydrogen sorption capabilities. Such nanoporous materials mainly focused on nowadays are silica such as MCM‐41, SBA‐15 and hollow silica materials [117,119,120] …”

Section: Research Trends On Porous Scaffoldsmentioning

confidence: 99%

Progress and Advances in Porous Silica‐based Scaffolds for Enhanced Solid‐state Hydrogen Storage: A Systematic Literature Review

Abdulkadir,

Jalil,

Cheng

et al. 2023

Chemistry An Asian Journal

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Hydrogen plays a crucial role in the future energy landscape owing to its high energy density. However, finding an ideal storage material is the key challenge to the success of the hydrogen economy. Various solid‐state hydrogen storage materials, such as metal hydrides, have been developed to realize safe, effective, and compact hydrogen storage. However, low kinetics and thermodynamic stability lead to a high working temperature and a low hydrogen sorption rate of the metal hydrides. Using scaffolds made from porous materials like silica to confine the metal hydrides is necessary for better and improved hydrogen storage. Therefore, this article reviews porous silica‐based scaffolds as an ideal material for improved hydrogen storage. The outcome showed that confining the metal hydrides using scaffolds based on porous silica significantly increases their storage capacities. It was also found that the structural modifications of the silica‐based scaffold into a hollow structure further improved the storage capacity and increased the affinity and confinement ability of the metal hydrides, which prevents the agglomeration of metal particles during the adsorption/desorption process. Hence, the structural modifications of the silica material into a fibrous and hollow material are recommended to be crucial for further enhancing the metal hydride storage capacity.

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A phase II study of mitomycin-C and S-1 as third-line chemotherapy in patients with advanced colorectal cancer

Cited by 4 publications

References 16 publications

HeLa cell response to mitomycin C. I. cell division

HeLa cell response to mitomycin C. I. cell division

Potential Applications of Metal‐Doped Nanomaterials for Enhancing Solid‐State Hydrogen Storage

Progress and Advances in Porous Silica‐based Scaffolds for Enhanced Solid‐state Hydrogen Storage: A Systematic Literature Review

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