A phase II randomized, double-blind placebo-controlled trial of an antiemetic, 6-gingerol in solid tumor patients receiving moderately to highly emetogenic adjuvant chemotherapy.

Konmun, Jitprapa; Danwilai, Kwanjit; Ngamphaiboon, Nuttapong; Sookprasert, Aumkhae; Sirachainan, Ekaphop; Subongkot, Suphat

doi:10.1200/jco.2014.32.15_suppl.9647

Cited by 4 publications

(11 citation statements)

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“…There were no significant differences between groups regarding adverse effects (p> 0.05). (23) 2014/ Thailand Randomized, doubleblind, controlled clinical trial, n = 87.…”

Section: Design/number Of Patientsmentioning

confidence: 99%

“…Regarding the antiemetic action of ginger, 13 studies observed the action of ginger in nausea (14,16,(20)(21)(23)(24)(25)(26)(27)(28)(29)(30)37) ; of these, 9 (16,(23)(24)(25)(26)(27)(28)(29)(30) presented significant results considering significance level of 5% (p < 0.001 (16) ; p = 0.002 (23) ; p = 0.0001 (24) ; p = 0.04 (26) ; p = 0.0003 (27) , p = 0.003 (29)(30) ). As for emesis, 11 investigations (13,(15)(16)(20)(21)23,25,(28)(29)33,35) described advantages in this therapy, and 6 presented a result with a significance level of less than 5% (p < 0.0 01 (16,23) ; p < 0.0001 (20) ; p < 0.05 (21) ; p = 0.002 (29) ; p = 0.04 (35) ).…”

Section: Note: Flie: Functional Living Index Emesismentioning

confidence: 99%

“…Regarding the influence of this intervention on the control of nausea and vomiting in the acute phase, 11 publications were detected that analyzed nausea in the acute phase (15)(16)(22)(23)(24)(25)(26)(27)(28)(29)(30) , among which 8 (23)(24)(25)(26)(27)(28)(29)(30) detected advantages, but only 6 investigations had statistically significant results with p < 5% (p = 0.002 (23) ; p = 0.0001 (24) ; p = 0.04 (26) ; p = 0.0003 (27) , p = 0.003 (29)(30) ). Regarding emesis, 8 studies analyzed the acute stage (14,18,(21)(22)24,(27)(28)34) ; of these, 6 (19,23,25,28,34) observed the therapeutic effect of ginger, but only 2 had significant results considering significance level of 5% (p = 0.002 (29) ; p = 0.04 (35) ). Regarding the influence on the control of nausea and vomiting in the delayed phase, 6 studies (15)(16)(22)(23)(28)…”

Section: Note: Flie: Functional Living Index Emesismentioning

confidence: 99%

“…Regarding emesis, 8 studies analyzed the acute stage (14,18,(21)(22)24,(27)(28)34) ; of these, 6 (19,23,25,28,34) observed the therapeutic effect of ginger, but only 2 had significant results considering significance level of 5% (p = 0.002 (29) ; p = 0.04 (35) ). Regarding the influence on the control of nausea and vomiting in the delayed phase, 6 studies (15)(16)(22)(23)(28)(29) analyzed delayed nausea, 4 observed advantages in the use of ginger (15,22,(27)(28) . Of the investigations, 3 had significant results (p < 0.001 (16,23,29) ).…”

Section: Note: Flie: Functional Living Index Emesismentioning

confidence: 99%

“…Regarding the influence on the control of nausea and vomiting in the delayed phase, 6 studies (15)(16)(22)(23)(28)(29) analyzed delayed nausea, 4 observed advantages in the use of ginger (15,22,(27)(28) . Of the investigations, 3 had significant results (p < 0.001 (16,23,29) ). In the emesis, 6 publications (15,(22)(23)(28)(29)35) evaluated the delayed phase, and 4 (23,(28)(29)35) described that ginger assisted in the management of this symptom; of these, 3 (22,28,34) showed significant results (p < 0.001 (23) ; p = 0.022 (29) ; p = 0.003 (35) ).…”

Section: Note: Flie: Functional Living Index Emesismentioning

confidence: 99%

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Benefits of ginger in the control of chemotherapy-induced nausea and vomiting

et al. 2020

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Objectives: To identify and discuss scientific evidence of the effects of ginger use on the management of chemotherapy-induced nausea and vomiting. Methods: This is an integrative reviewperformed by Ganong’s reference. Results: We included 24 studies, highlighting three thematic categories, namely 1) antiemetic action of ginger - nausea (13 articles; of these, nine significant) and emesis (10 studies; of these, six significant); 2) action in the control of nausea (11 articles; of these, six significant) and vomiting (8 articles; of these, three significant) in the acute phase; 3) action in the control of nausea (6 articles; of these, three significant) and vomiting (6 articles; of these, three significant) in the delayed phase. There were divergences of the methods used. Final considerations: This complementary therapy has low cost and easy access, but no statistical confirmation of its effectiveness in the management of nausea and vomiting in cancer patients was found.

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“…There were no significant differences between groups regarding adverse effects (p> 0.05). (23) 2014/ Thailand Randomized, doubleblind, controlled clinical trial, n = 87.…”

Section: Design/number Of Patientsmentioning

confidence: 99%

Section: Note: Flie: Functional Living Index Emesismentioning

confidence: 99%

Section: Note: Flie: Functional Living Index Emesismentioning

confidence: 99%

Section: Note: Flie: Functional Living Index Emesismentioning

confidence: 99%

Section: Note: Flie: Functional Living Index Emesismentioning

confidence: 99%

See 3 more Smart Citations

Benefits of ginger in the control of chemotherapy-induced nausea and vomiting

et al. 2020

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Cost-effectiveness analysis of olanzapine-containing antiemetic therapy for managing highly emetogenic chemotherapy in Southeast Asia: a multinational study

Chanthawong

Lim

Subongkot

et al. 2018

Support Care Cancer

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Counseling on Complementary Methods in the Treatment of Side Effects of Oncological Therapies: A Project of the Breast and Bowel Center Nahe at the Hospital Sankt Marienwoerth Bad Kreuznach

Muecke

Gosenheimer

Schulz³

et al. 2021

Integr Cancer Ther

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Background: Increasingly, patients with cancer are asking for additional, complementary therapy options for treating the side effects of oncological therapy. Thus, the members of the Breast and Bowel Center Nahe at the Sankt Marienwörth Hospital Bad Kreuznach decided to define the content of this type of counseling for patients before treatment. Methods: In 2018, a team of internal oncologists, gynecological oncologists, radio-oncologists, nutritionists, psycho-oncologists, and study nurses met several times to define the content of counseling. To inform the team, an intensive literature review was conducted. Results: Counseling content was determined for complementary treatment options for the most frequent side effects of oncological therapies. Counseling sessions were formulated as frontal lectures (slide presentations), given at regular intervals for patients and relatives. These lectures were highly appreciated by patients. Conclusion: These counseling sessions increased patient understanding of both useful complementary measures and harmful measures they should not use.

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A phase II randomized, double-blind placebo-controlled trial of an antiemetic, 6-gingerol in solid tumor patients receiving moderately to highly emetogenic adjuvant chemotherapy.

Cited by 4 publications

References 0 publications

Benefits of ginger in the control of chemotherapy-induced nausea and vomiting

Benefits of ginger in the control of chemotherapy-induced nausea and vomiting

Cost-effectiveness analysis of olanzapine-containing antiemetic therapy for managing highly emetogenic chemotherapy in Southeast Asia: a multinational study

Counseling on Complementary Methods in the Treatment of Side Effects of Oncological Therapies: A Project of the Breast and Bowel Center Nahe at the Hospital Sankt Marienwoerth Bad Kreuznach

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