volume 93, issue 0, P3-P-311 2020
DOI: 10.1254/jpssuppl.93.0_3-p-311
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Abstract: Asthma-COPD overlap (ACO) rapidly deteriorates the respiratory function and is steroid resistant, and its effective treatment has not been established. The effects of dexamethasone (Dex) and roflumilast (Rof) on the asthma model sensitized and challenged by ovalbumin (OVA), and the ACO model exposed to OVA and cigarette smoke (CS) in BALB/c mice were examined. In the OVA + CS group, the peak expiratory flow, tidal volume, Newtonian resistance (Rn, central airways resistance) and airway reactivity to methacholi…

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