A pH-sensitive delivery system based on N-succinyl chitosan-ZnO nanoparticles for improving antibacterial and anticancer activities of curcumin

Ghaffari, Seyed-Behnam; Sarrafzadeh, Mohammad‐Hossein; Salami, Maryam; Khorramizadeh, Mohammad Reza

doi:10.1016/j.ijbiomac.2020.02.141

Cited by 98 publications

(51 citation statements)

References 71 publications

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“…Other than this, the conjugate exhibited a pHresponsive drug release owing to the use of Nsuccinyl chitosan, allowing the drug release at the target site. The increased therapeutic activity arises from the combined use of ZnNP, chitosan, and curcumin [48].…”

Section: Drug and Gene Deliverymentioning

confidence: 99%

Advances of Non-Iron Metal Nanoparticles in Biomedicine

Nair¹,

Morsy²,

Shinu³

et al. 2021

J Pharm Pharm Sci

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Metal nanoparticles (MNPs) comprise of nanoparticles originating from metallic elements with additional properties inherent to metal ions. MNPs found applications in various field such as electronics, optics, mechanics, physics etc. There are many reviews on iron MNPs for biomedical application. Hence, in this review, we focus on non-iron MNPs and their vivid biomedical applications. Here, we review the applications of non-iron MNPs in biomedicine such as drug delivery, gene delivery, anticancer activity, antimicrobial activity, tissue engineering, bioimaging, and photodynamic, and photothermal therapies.

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Section: Drug and Gene Deliverymentioning

confidence: 99%

Advances of Non-Iron Metal Nanoparticles in Biomedicine

Nair¹,

Morsy²,

Shinu³

et al. 2021

J Pharm Pharm Sci

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“…The maximum immobilization yield of catalase (84.32%) was detected at 0.2g Fe 2 O 3 Np and pH 8.0, with 500 unit/g support and 855 units of immobilized catalase/mg protein loaded (Table 1). The improvement in immobilization enzyme can be attributed to the strong interaction between the amino group in chitosan with iron (III) oxide and zinc oxide [24]. In previous work, chitosan activated with cyanuric chloride was used as a support for peroxidase, with the maximum immobilization of 60% [9].…”

Section: Immobilization Of Catalase Enzymementioning

confidence: 99%

Immobilization of Catalase on Chitosan/ZnO and Chitosan/ZnO/Fe2O3 Nanocomposites: A Comparative Study

2021

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The strong catalytic performance, eco-friendly reaction systems, and selectivity of enzyme-based biocatalysts are extremely interesting. Immobilization has been shown to be a good way to improve enzyme stability and recyclability. Chitosan-incorporated metal oxides, among other support matrices, are an intriguing class of support matrices for the immobilization of various enzymes. Herein, the cross-linked chitosan/zinc oxide nanocomposite (CS/ZnO) was synthesized and further improved by adding iron oxide (Fe2O3) nanoparticles. The final cross-linked CS/ZnO/Fe2O3 nanocomposite was used as an immobilized support for catalase and is characterized by SEM, EDS, and FTIR. The nanocomposite CS/ZnO/Fe2O3 enhanced the biocompatibility and immobilized system properties. CS/ZnO/Fe2O3 achieved a higher immobilization yield (84.32%) than CS/ZnO (37%). After 10 repeated cycles, the remaining immobilized catalase activity of CS/ZnO and CS/ZnO/Fe2O3 was 14% and 45%, respectively. After 60 days of storage at 4 °C, the remaining activity of immobilized enzyme onto CS/ZnO and CS/ZnO/Fe2O3 was found to be 32% and 47% of its initial activity. The optimum temperature was noticed to be broad at 25–30 °C for the immobilized enzyme and 25 °C for the free enzyme. Compared with the free enzyme optimum pH (7.0), the optimum pH for the immobilized enzyme was 7.5. The Km and Vmax values for the free and immobilized enzyme on CS/ZnO, and the immobilized enzyme on CS/ZnO/Fe2O3, were found to be 91.28, 225.17, and 221.59 mM, and 10.45, 15.87, and 19.92 µmole ml−1, respectively. Catalase immobilization on CS/ZnO and CS/ZnO/Fe2O3 offers better stability than free catalase due to the enzyme’s half-life. The half-life of immobilized catalase on CS/ZnO/Fe2O3 was between 31.5 and 693.2 min.

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“…of ZnO nanoparticles will lead to less content of CHT in the whole molecular structure of the composite material as a result less amine group content will be obtained [15]. Another possible reason is the coordination of zinc ions with the amino and hydroxyl groups, which may lead to reduce the free amino group content [28].…”

Section: Adsorption Study Of Rbbr On Cht-gla/zno/fe3o4mentioning

confidence: 99%

“…Recently, CHT/ZnO nanocomposites have received great attention as a key material in many applications such as food packaging [26], wastewater treatment [27], antibacterial [28], and biosensor [29]. Currently, magnetic adsorbents are receiving great attention from researchers due to its easy collection from an aqueous solution by magnetic tool after adsorption process.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Chitosan-Glutaraldehyde/Zinc Oxide/Fe3O4 Nanocomposite: Optimization and Adsorptive Mechanism of Remazol Brilliant Blue R Dye Removal

et al. 2021

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A magnetic Schiff's base chitosan-glutaraldehyde/Fe3O4 composite (CHT-GLA/ZnO/Fe3O4) was developed by incorporating zinc oxide (ZnO) nanoparticles into its structure to prepare an efficient adsorbent for the removal of remazol brilliant blue R (RBBR) dye. The CHT-GLA/ZnO/Fe3O4 was characterized by the following methods: CHN, BET, FTIR, XRD, SEM-EDX, pHpzc, and potentiometric titrations. Box-Behnken design based on response surface methodology was used to optimize the effects of the A: ZnO nanoparticles loading (0-50%), B: dose (0.02-0.1 g), C: pH (4-10), D: temperature (30-60 °C), and time E: (10-60 min) on the synthesis of the magnetic adsorbent and the RBBR dye adsorption. The experimental data of kinetics followed the pseudo-second order model, while isotherms showed better fit to Freundlich and Temkin models. The maximum adsorption capacity of the target nanocomposite (CHT-GLA/Fe3O4 containing 25% ZnO or CHT-GLA/ZnO/Fe3O4-25) was reached of 176.6 mg/g at 60 °C. The adsorption mechanism of RBBR onto CHT-GLA/ZnO/Fe3O4 nanocomposite can be attributed to multi-interactions including electrostatic attractions, hydrogen bonding, Yoshida Hbonding, and n-π interactions. This study offers a promising hybrid nanobiomaterial adsorbent in environmental nanotechnology to separate and remove the contaminants such as organic dyes from wastewater.

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A pH-sensitive delivery system based on N-succinyl chitosan-ZnO nanoparticles for improving antibacterial and anticancer activities of curcumin

Cited by 98 publications

References 71 publications

Advances of Non-Iron Metal Nanoparticles in Biomedicine

Advances of Non-Iron Metal Nanoparticles in Biomedicine

Immobilization of Catalase on Chitosan/ZnO and Chitosan/ZnO/Fe2O3 Nanocomposites: A Comparative Study

Magnetic Chitosan-Glutaraldehyde/Zinc Oxide/Fe3O4 Nanocomposite: Optimization and Adsorptive Mechanism of Remazol Brilliant Blue R Dye Removal

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