A pH-responsive MOF for site-specific delivery of fungicide to control citrus disease of Botrytis cinerea

Zhang, Xuqian; Tang, Xinyi; Zhao, Chenchen; Yuan, Zitong; Zhang, Di; Zhao, Hui; Yang, Ni; Guo, Kunyan; He, Ying; He, Yuke; Hu, Junhua; He, Lina; He, Lin; Qian, Kun

doi:10.1016/j.cej.2021.133351

Cited by 33 publications

(40 citation statements)

References 26 publications

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“…After 5 days of treatment, the cumulative release rates of β-CYP/ZIF-8 nanoparticles reached 66.95 ± 2.36 and 98.20 ± 3.61% at pH 6.0 and 4.5, respectively, largely exceeding those under neutral conditions (pH 7.4). This tendency was due to acidic conditions that can protonate organic ligands, leading to the cleavage of the Zn + –imidazolium ion coordination bond, thereby decomposing the ZIF-8 skeleton to release the drug …”

Section: Resultsmentioning

confidence: 99%

pH-Responsive ZIF-8-Based Metal–Organic-Framework Nanoparticles for Termite Control

Zhao

Shang

et al. 2022

ACS Appl. Nano Mater.

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Pesticides are the primary defending strategy against major biological invaders and important for ensuring national food security. Intelligent nanopesticides with precise controlled release modes are currently an emerging area of interest in the field of green, safe, and sustainable pesticide formulation. In this study, βcypermethrin (β-CYP) was loaded into ZIF-8 by the one-pot method, which successfully prepared a pH-responsive delivery nanoparticle (β-CYP/ZIF-8) to control termites. Results demonstrated that β-CYP/ZIF-8 had a mean diameter of 188 ± 2 nm and a loading capacity of approximately 21%. In vitro release experiments showed that β-CYP/ZIF-8 releases better in acidic than in neutral conditions due to the presence of intermediate acidunstable imidazole organic compounds. The acidic microenvironment in which termites thrive can promote β-CYP release due to ZIF-8 decomposition, thus improving pesticide targeting and reducing toxic side effects. The bioactivity survey confirmed that β-CYP/ZIF-8 could control termites (Coptotermes formosanus Shiraki) for a longer duration compared to commercial wettable powder (WP) and emulsifiable concentrate (EC). Moreover, an acute toxicity test showed an over 2-and 10-fold reduction in the acute toxicity of β-CYP/ZIF-8 to earthworms and zebrafish, respectively, compared to that of commercial WP and EC. Finally, the cytotoxicity assay of β-CYP/ZIF-8 showed higher safety to human hepatocyte LO2 cells. Overall, these β-CYP/ZIF-8 nanoparticles, prepared using the one-pot method, have great application potential in sustainable pest management and protection of the ecological environment.

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Section: Resultsmentioning

confidence: 99%

pH-Responsive ZIF-8-Based Metal–Organic-Framework Nanoparticles for Termite Control

Zhao

Shang

et al. 2022

ACS Appl. Nano Mater.

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“…Recently, nanoformulations based on metal–organic frameworks (MOFs) represent an attractive alternative to improve the efficiency of agrochemicals. , Cargos are loaded in the nano-frameworks and avoid direct contact with the medium, which achieves cargo-sustained release. For example, an MOF core made of MIL-101(Fe) coated with silica was prepared to load the insecticide chlorantraniliprole; ZIF-67, a subclass of MOF, was prepared to encapsulate boscalid, and the combination of UiO-66 and sodium alginate was used to control the release of clothianidin . Zeolitic imidazolate framework-8 (ZIF-8) as a green MOF, consisting of zinc ion (Zn 2+ ) and 2-methylimidazole (2-HmIm), has been designed as a pH-responsive carrier for controlled delivery of agrochemicals. , In addition, ZIF-8 can be decomposed into soluble zinc ions in the water environment, which can be used as nutrients and ultimately reduce environmental pollution .…”

Section: Introductionmentioning

confidence: 99%

MOF Hybrid for Long-Term Pest Management and Micronutrient Supply Triggered with Protease

Wang

Yang

et al. 2022

ACS Appl. Mater. Interfaces

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Advanced intelligent systems for delivery of pesticides or fertilizers require formulations that allow for long-term efficacy. In this work, a metal–organic framework (MOF) hybrid was developed for long-term pest management and micronutrient supply. Zeolitic imidazolate framework-8 was fabricated for crop micronutrients (Zn2+) supply and insecticide dinotefuran (DNF) encapsulation. Polymethylmethacrylate was polymerized in situ to impart the MOF hybrid with sustained cargo delivery. Then, zein was introduced to facilitate protease-triggered cargo release associated with the microenvironment of pests and targeted release. The resulting MOF hybrid exhibited stimulus-responsive, slow-release behaviors. Sustained DNF delivery was achieved over a period of at least 32 days in soil. Compared with that of free DNF, the UV resistance of DNF in the MOF hybrid increased by nearly 10 times, and the insecticidal efficiency increased 33.3% with leaching treatment and 40.1% after incubating in a greenhouse for 14 days. This MOF hybrid provides a controlled, targeted, and sustained delivery formulation for long-term pest management and crop micronutrient supply and has huge application prospects in sustainable agriculture.

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“…In recent years, stimuli-responsive pesticide delivery systems based on nanocarriers have attracted widespread attention due to their ability to control pesticide release, improve target activity, and minimize the adverse effects on the environment [ 9 , 10 , 11 , 12 ]. Among various nanocarriers explored, Zn-based metal–organic frameworks (ZIF-90) as pesticide carriers for stimuli-responsive pesticide delivery systems have a number of unique advantages, such as facile synthesis route, high porosity, abundant aldehyde groups, outstanding biocompatibility, and being environmentally friendly [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Zeolitic Imidazole Framework-90-Based Pesticide Smart-Delivery System with Enhanced Antimicrobial Performance

et al. 2022

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Multimodal antimicrobial technology is regarded as a promising strategy for controlling plant diseases because it enhances antimicrobial efficacy by blocking multiple pesticide-resistance pathways. In this work, a pH-responsive multimodal antimicrobial system was constructed based on ZIF-90 for the controlled release of kasugamycin (KSM). A series of physicochemical characterizations confirmed the successful fabrication of ZIF-90-KSM. The results indicated that the loading capacity of ZIF-90-KSM for KSM was approximately 6.7% and that the ZIF-90 nanocarriers could protect KSM against photodegradation effectively. The acid pH at the site of disease not only decompose the Schiff base bonds between KSM and ZIF-90, but also completely dissolved the nanocarriers. The simultaneous release of KSM and Zn2+ ions was able to achieve multimodal antimicrobial functions during disease occurs. A bioactivity survey indicated that ZIF-90-KSM had superior fungicidal activity and longer duration against Magnaporthe oryzae than KSM aqueous solution. In addition, the phytotoxicity assessment of ZIF-90-KSM on rice plants did not reveal any adverse effects. Therefore, ZIF-90-KSM prepared by Schiff base reaction has great potential for achieving synergistic antifungal functions and provides an eco-friendly approach to manage rice diseases.

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A pH-responsive MOF for site-specific delivery of fungicide to control citrus disease of Botrytis cinerea

Cited by 33 publications

References 26 publications

pH-Responsive ZIF-8-Based Metal–Organic-Framework Nanoparticles for Termite Control

pH-Responsive ZIF-8-Based Metal–Organic-Framework Nanoparticles for Termite Control

MOF Hybrid for Long-Term Pest Management and Micronutrient Supply Triggered with Protease

Zeolitic Imidazole Framework-90-Based Pesticide Smart-Delivery System with Enhanced Antimicrobial Performance

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