A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner

Influence of seasonal variation on Thymus longicaulis C. Presl chemical composition and its antioxidant and anti-inflammatory properties

“…Vinblastine (0.01 lM) served as positive control. The cytotoxic effect of the treatment was determined as percentage of viability compared to untreated cells using the following formula: (absorbance of treated cells/absorbance of untreated cells) Â 100 (Rinner et al, 2010). 4.7.…”

Anti-tumor effects of shikonin derivatives on human medullary thyroid carcinoma cells

“…Shikonins are known to possess several pharmacological effects including anti-bacterial, wound-healing, anti-inflammatory and anti-cancer properties (9, 10, 11, 12, 13). The anti-cancer effects have been shown to be linked to fundamental cellular processes such as cell cycle progression, apoptosis (19, 20) and mitochondrial function (27, 28). Shikonins further affect main anti-apoptotic and pro-proliferative pathways such as MAPK and AKT signaling cascades (29, 30), but the effects on MTC cells with respect to migration and invasion as well as in vivo tumor growth have not yet been investigated.…”

“…The potencies of the pure substances acetylshikonin, β,β-dimethylacrylshikonin and shikonin were compared with the unfractionated petroleum ether extract by converting the IC 50 values from µM to µg/mL. Interestingly, application of the extract, which contains several shikonin derivatives (19), did not show better anti-tumor efficiency than single pure compounds. In fact, the IC 50 of the extract (i.e.…”

“…As described previously (19, 20), shikonin derivatives were isolated from Onosma paniculata Bureau & Franchet. Briefly, a petroleum ether extract (EX) was prepared by exhaustive Soxhlet extraction and further fractionated using preparative HPLC.…”

Antioxidant activity and cytotoxicity ofCyrtosperma johnstoniiextracts on drug sensitive and resistant leukemia and small cell lung carcinoma cells

“…& Franch. (Boraginaceae) induce apoptosis in leukemia cells (Kim et al, 2010;Rinner et al, 2010). We therefore further investigated the effect on cell cycle progression of the acetone extract of C. johnstonii as it showed the most cytotoxic activities.…”