2007
DOI: 10.1038/nnano.2006.206
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Abstract: Microfabricated regular sieving structures hold great promise as an alternative to gels to improve biomolecule separation speed and resolution. In contrast to disordered gel porous networks, these regular structures also provide well-defined environments ideal for study of molecular dynamics in confining spaces. However, previous regular sieving structures have been limited for separation of long DNA molecules, and separation of smaller, physiologically-relevant macromolecules, such as proteins, still remains … Show more

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Cited by 306 publications
(336 citation statements)
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“…Of particular interest is the intricate interplay among surface chemistry, electrokinetics, and fluid dynamics spanning over molecular and continuum macroscopic length scales [4,5]. It has been demonstrated that the electrokinetic properties at this scale have enabled a range of innovations including those for chemical sensing and bioanalytics [6][7][8][9][10][11][12], energy harvesting systems, [13][14][15][16][17][18], and nanofluidic ion transport [19][20][21][22][23][24][25][26], including enrichment, depletion, and rectification effects [27][28][29][30][31][32].…”
Section: Introductionmentioning
confidence: 99%
“…Of particular interest is the intricate interplay among surface chemistry, electrokinetics, and fluid dynamics spanning over molecular and continuum macroscopic length scales [4,5]. It has been demonstrated that the electrokinetic properties at this scale have enabled a range of innovations including those for chemical sensing and bioanalytics [6][7][8][9][10][11][12], energy harvesting systems, [13][14][15][16][17][18], and nanofluidic ion transport [19][20][21][22][23][24][25][26], including enrichment, depletion, and rectification effects [27][28][29][30][31][32].…”
Section: Introductionmentioning
confidence: 99%
“…As a computationally efficient explicitsolvent method, CGH-MD is potentially useful for simulating systems of large number of water particles to complement more rigorous methods. It may also be applied to the study of polar and hydrophobic effects, 13 nonuniformly distributed electrostatic interactions, and the effects associated with bound and sequestered water molecules 12,13 in various bio-macromolecular and nanofluidic systems such as the electrophoresis of DNA, 36 proteins, 60 viral particles, and complexes 61 in nanofluidic, 34,58,59,62 microfluidic, 63,64 and microstructure array 16,65 systems. …”
Section: Ion Distribution Patternmentioning
confidence: 99%
“…19,33 It was then tested on the computation of nonuniform distribution of ions in a cylindrical nanotube by comparing our result with that of CG-MD. 33,34 Our method was further evaluated by using it to simulate the process of DNA electrophoresis in a polymer solution and in a well-studied nanofluidic device to compare its performance with observations and other simulation studies 5,6 and to evaluate its computing cost with respect to those of other methods.…”
Section: Introductionmentioning
confidence: 99%
“…Another reported variant of the 'DNA prism' device was a self-patterned 3D crystalline nanoarray used for fractionating smaller DNA molecules (2-50 kbp) in a continuous flow setup 15 . Other separation principles, including Ogston sieving, entropic trapping, and electrostatic sieving, were demonstrated by Fu et al using a nanofabricated two-dimensional (2D) sieving array operated under pulsed electric fields to fractionate DNA in a continuous flow 16 .…”
Section: Introductionmentioning
confidence: 99%
“…However, defectfree fabrication of the 3D nanostructures, such as the nanopost array 11 and the crystalline nanoarray 15 , is extremely challenging. Although the manufacturing of 2D nanostructures (for example, the anisotropic nanofluidic sieving array 16 ) is relatively easier, these nanostructures intrinsically yield low sample throughput. An ideal sieving matrix should thus have a simple design and facile fabrication steps yet provide high-resolution and high-throughput separation.…”
Section: Introductionmentioning
confidence: 99%