A paraneoplastic mixed bullous skin disease associated with anti-skin antibodies and a B-cell lymphoma

High-dose-rate intraluminal brachytherapy for paraneoplastic autoimmune multiorgan syndrome

“…Painful oral erosive ulcers and various forms of skin rashes are typical skin lesions associated with PAMS (2). In particular, stomatitis is a common clinical symptom in PAMS patients (1,9–11).…”

“…Skin lesions associated with autoantibodies may not only be pemphigus lesions, but also erythema multiforme-like lesions, graft-versus-host disease-like lesions and lichen planus lesions (1,2). These diseases may also cause mortality due to the infiltration of autoantibodies into other organs, thus leading to the term paraneoplastic autoimmune multiorgan syndrome (PAMS) (2). …”

“…Lymphoid hyperplasia is the rapid growth and proliferation of normal cells that resemble lymph tissue, and the majority of lymphoid hyperplasia cells are T lymphocytes (2,3). Neoplasms associated with lymphoid hyperplasia include Castleman's disease, non-Hodgkin's lymphoma and thymoma, and these tumors have been frequently associated with PAMS (2).…”

Graft-versus-Host-Like Mucocutaneous Eruptions with Serological Features of Paraneoplastic Pemphigus and Systemic Lupus erythematosus in a Patient with Non-Hodgkin’s Lymphoma

“…The entities of PNP and the recently described paraneoplastic mixed bullous skin disease associated with a B-cell lymphoma and antiskin antibodies (to antigens of approximately 150, 180, 230 and 285 kD) [24] represent two well-defined manifestations of tumor-induced dysimmunoreactivity. Several overlap dermatoses of autoimmune dermatoses [25, 26] are known to exhibit characteristic features of both diseases without associated neoplasms, however.…”

Oral Lesions and Lymphoproliferative Disorders

“…In the literature there are numerous works reported that associate mucous membrane pemphigoid (MMP) with malignancies, including lung cancer [83], pancreatic adenocarcinoma [84], gastric adenocarcinoma [85], and squamous cell carcinoma of the conjunctiva [86] there are only two cases reported of MMP with oral manifestations associated to lymphoproliferative disorders: a B-cell lymphoma [87] and chronic lymphocytic leukemia [88]. It has been described in the literature that large amount of cases have connection between bullous pemphigoid (BP) and lymphoproliferative disorders such as chronic lymphocytic leukemia [89–91] and lymphoblastic lymphoma [92].…”