2018
DOI: 10.18632/aging.101473
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Abstract: Ovarian cancer yields the highest mortality rate of all lethal gynecologic cancers, and the prognosis is unsatisfactory with the major obstacle in resistance to chemotherapy. The generation of reactive oxygen species (ROS) in tumor tissues was associated with chemotherapeutic effectiveness by mediating cellular longevity. In this study, we screened the prognostic values of oxidative stress-related genes in ovarian cancer patients received platinum-based chemotherapy, and conducted a prognostic gene signature c… Show more

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Cited by 9 publications
(8 citation statements)
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References 26 publications
(22 reference statements)
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“…Currently, clinical features such as tumor grade, histopathological classification, debulking status, and CA-125 levels are the most common criteria to evaluate the risk of HGSOC patients [27]. Although a lot of multigene prognostic signatures [9, 2830] have been developed, the accuracy of their prognostic prediction remains uncertain. A method to identify EOC patients with a worse prognosis is urgently needed to improve the design of customized therapies.…”
Section: Discussionmentioning
confidence: 99%
“…Currently, clinical features such as tumor grade, histopathological classification, debulking status, and CA-125 levels are the most common criteria to evaluate the risk of HGSOC patients [27]. Although a lot of multigene prognostic signatures [9, 2830] have been developed, the accuracy of their prognostic prediction remains uncertain. A method to identify EOC patients with a worse prognosis is urgently needed to improve the design of customized therapies.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, patients with ESCC exhibiting low expression of antioxidant proteins in the Nrf2 signaling pathway in pre-therapeutic endoscopic biopsy specimens are considered reasonably suitable candidates for dCRT. In addition, results of several studies have also suggested that Nrf2 and TXNRD1 are useful markers for predicting the e cacy of chemotherapy or irradiation therapy in other neoplasms, such as non-small cell lung cancer or ovarian cancer [46,47]. However, further investigation is necessary for con rming these propositions.…”
Section: Discussionmentioning
confidence: 99%
“…Functional in vitro validations showed that TAT induced apoptosis and that TAT possessed tumor-suppressive functions [23]. GSTZ1, which is expressed in both hepatic cytosol and mitochondria, has shown to be oxidative stress-related [29]. High levels of GSTZ1 expression conferred resistance to the effect of anti-cancer therapy of dichloroacetate in hepatocellular carcinoma cell lines by an independent mechanism to tyrosine metabolism [49,50].…”
Section: Plos Onementioning
confidence: 99%
“…Patients carrying GSTZ1 variants had an increased risk of bladder cancer when exposed to trihalomethanes [28]. Furthermore, a computational-based investigation suggested GSTZ1 might act as a protective factor in ovarian cancer [29].…”
Section: Introductionmentioning
confidence: 99%