A panel of stomach‐specific biomarkers (GastroPanel®) for the diagnosis of atrophic gastritis: A prospective, multicenter study in a low gastric cancer incidence area

Abstract

Background Analysis of serum biomarkers for the assessment of atrophic gastritis (AG), considered as gastric precancerous lesion, is of growing interest and recommended by current guidelines. Our aim was to evaluate the diagnostic performance of a panel of biomarkers (GastroPanel®) for the detection of AG in France, a country of a low gastric cancer (GC) incidence. Material and Methods In this prospective, multicenter, cross‐sectional study, consecutive patients considered at increased risk of GC and undergoing upper endoscopy with gastric biopsies were included. Blood samples were collected for the analysis of GastroPanel® (association of Pepsinogens I and II, Gastrin‐17, and Helicobacter pylori serology) using ELISA. The results of GastroPanel® were compared to the results of histology considered as the reference. Results Between 2016 and 2019, 344 patients (148 cases with AG, 196 controls without AG) were included. Sensitivity, specificity, positive, and negative predictive values for the detection of AG by GastroPanel® were of 39.9% (95% CI 31.9; 48.2), 93.4% (95% CI 88.9; 96.4), 81.9 (95% CI 71.1; 90.0), and 67.3 (95% CI 61.4; 72.8), respectively. The sensitivity was significantly higher for the detection of severe AG [60.8% (95% CI 46.1; 74.6) P = .015] and corpus AG [61.0% (95% CI 49.2; 72.0), P = .004]. Diagnostic performances of GastroPanel® tended to be better than those of Pepsinogen I alone, but the difference did not reach statistical significance (P = .068). Conclusion Serum pepsinogen and GastroPanel® tests show promising results for the detection of AG, especially of corpus AG and severe AG, in patients at high risk of GC in France.

Serum Gastrin and Pepsinogen Levels after Administration of Acid Secretion Inhibitors for Ulcers due to Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer

“…However, in our study, the median serum gastrin level following the administration of vonoprazan (20 mg) for 4 weeks was 2,470 pg/mL, which is similar to the level in a previous report by Iwakiri et al [22]. Thus, patients may experience a sharp increase in the serum In recent years, Western countries have demonstrated that the serum level of G17, which is secreted from the antral G cells, has been used to evaluate the topography of gastritis by GastroPanel [23][24][25][26]. However, in Japan, the serum titer of gastrin has been used for the evaluation of corpus atrophy, and total gastrin is evaluated using the domestic enzyme-linked immunosorbent assay system.…”

Microbiota changes with fermented kimchi contributed to either the amelioration or rejuvenation of <i>Helicobacter pylori</i>-associated chronic atrophic gastritis

“…( 59 – 61 ) Though follow-up endoscopy for Updated Sydney System to evaluate atrophic gastritis in the current study is prerequisite, the analysis of serum biomarkers for the assessment of CAG using stomach-specific diagnostic performance of GastroPanel ® was done. ( 62 – 64 ) As seen in Supplemental Fig. 3 * , the detection of corpus CAG and severe CAG was significantly improved in group taken 10 weeks of fermented kimchi relevant to gut microbiota changes.…”

Value of GastroPanel in the diagnosis of atrophic gastritis

“…This theory is supported by a group of French researchers who claim that GastroPanel has an insufficient diagnostic performance in case of mild gastric atrophy. However, it can be useful in selected groups of patients at high risk for gastric cancer, in particular to detect severe atrophy and corpus atrophy ( 29 ).…”