A One-Year Trial of Triamcinolone Acetonide Aerosol in Severe Steroid-Dependent Asthma

Subjective and Objective Evaluation of Voice Quality in Patients With Asthma

“…Particularly, high-dose inhaled steroids have been reported to cause dysphonia in 8% to 58% of the cases. 7,21,22 The most frequently reported side effects during inhaled treatment include hoarseness (1-5%), headache (2-5%), throat irritation (1-4%), and oral candidiasis (1-4%). 16 Acoustic voice analysis has been proposed as a simple and noninvasive means of detecting subclinical voice changes in a study examining the effects of inhaled steroids in asthma patients.…”

Voice problems as side effects of inhaled corticosteroids in asthma patients—a prevalence study

“…In a study of patients with severe asthma in which comparisons were made of the effects of administration of inhaled corticosteroids and oral steroids, it was found that hoarseness was the most frequently occurring side effect (52 %), with a general onset of 2 weeks after use of inhaled cortison. 13 Other studies reported that dysphonia was related to the dose and potency of inhaled steroids 8 and that the reason for high frequency of dysphonia may be caused by the relatively high dosages of Beclomethasone. 7 Very low prevalence of dysphonia was reported in a study designed to investigate the clinical use of spacer systems for corticosteroid inhalation therapy.…”

“…[7][8][9][10][11][12][13][14][15][16][17] Previous studies have concentrated mostly on the prevalence of voice disturbances among asthma patients treated with inhaled steroids. Some studies have focused on the efficiency of local treatment with corticosteroids, and dysphonia has been mentioned as a side effect.…”

Inhaled Corticosteroids: Hazardous Effects on Voice—An Update

“…Dysphonia, particularly with high-dose treatment, has varied in reported cases from 8% 2,11 up to 58% of patients. 2,12,13 The incidence of oropharyngeal and laryngeal candidiasis has varied from 0% to 77%. 1,8,12,14 Williams et al, in 1983, 15 recognized the occurrence of bowing of the vocal folds, ie, a spindle glottis, as associated with dysphonia caused by ICS.…”

“…2,12,13 The incidence of oropharyngeal and laryngeal candidiasis has varied from 0% to 77%. 1,8,12,14 Williams et al, in 1983, 15 recognized the occurrence of bowing of the vocal folds, ie, a spindle glottis, as associated with dysphonia caused by ICS. The incidence of dysphonia was found to be unrelated to that of candidiasis by Toogood et al 2, 16 Toogood and Shaw found that the incidence of sore throat was not related to candidiasis.…”