“…Second, as introduced previously, LES and DNS are the most advanced methods for cough/sneeze flow simulations. These methods can improve the accuracy of turbulent cough/sneeze puff prediction in indoor environments [ 27 , 28 , [31] , [32] , [33] , [34] ]. However, the significantly refined grid and time-dependent algorithm in turbulence resolution make it too expensive in terms of computational cost, especially for many practical applications such as complex scenarios with multiple infectious sources in a room and external conditions.…”