A Novel Visual Clue for the Diagnosis of Hypertrophic Lichen Planus

Welsh, John P.; Skvarka, Christopher B.; Allen, Herbert B.

doi:10.1001/archderm.142.7.954

Cited by 11 publications

(11 citation statements)

References 2 publications

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“…Welsh et al described its resemblance to the extrusive forms of igneous rock as a useful sign in distigushing the hypertrophic subtype from other differential diagnoses [28]. Polygonal Papules may be seen surrounding the main lesion.…”

Section: Resultsmentioning

confidence: 99%

Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

Gorouhi

Davari

Fazel

2014

The Scientific World Journal

381

391

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Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. LP can involve the skin or mucous membranes including the oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. It has different variants based on the morphology of the lesions and the site of involvement. The literature suggests that certain presentations of the disease such as esophageal or ophthalmological involvement are underdiagnosed. The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. LP can significantly affect the quality of life of patients as well. Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP. LP is a T-cell mediated immunologic disease but the responsible antigen remains unidentified. In this paper, we review the history, epidemiology, and clinical subtypes of LP. We also review the histopathologic aspects of the disease, differential diagnoses, immunopathogenesis, and the clinical and genetic correlations.

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Section: Resultsmentioning

confidence: 99%

Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

Gorouhi

Davari

Fazel

2014

The Scientific World Journal

381

391

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“…It is characterized by hyperkeratotic itchy papules and plaques, involving commonly the extremities, especially the anterior legs, also the upper extremities and trunk [2,3]. Welsh et al described « igneous rock sign » as characteristic clinical sign of HLP as its resemblance to the extrusive forms of igneous rock [3]. In our case, the patient had HLP on his face including the external auditory canal.…”

Section: Sirmentioning

confidence: 56%

“…Hypertrophic lichen planus (HLP) is a rare subtype of lichen planus (LP) that typically affects middleaged adults of both genders, mostly those with darker skinned [1][2][3]. It is characterized by hyperkeratotic itchy papules and plaques, involving commonly the extremities, especially the anterior legs, also the upper extremities and trunk [2,3]. Welsh et al described « igneous rock sign » as characteristic clinical sign of HLP as its resemblance to the extrusive forms of igneous rock [3].…”

Section: Sirmentioning

confidence: 99%

Hypertrophic lichen planus on the face

Korbi¹,

Rouatbi²,

Njima³

2020

Our Dermatol Online

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“…It is a frequently itchy dermatosis and it can present itself with annular, linear, bullous or atrophic lesions. [1][2][3] Hypertrophic lichen planus (HLP) represents the variety of LP in which the epidermis presents marked hyperplasia, due to persistent itching, being considered by some authors as a superposition of a chronic simple lichen to the LP lesions. 4 It is reported here a case of HLP with excellent response to oral treatment with acitretin.…”

Section: Introductionmentioning

confidence: 99%

“…2 Preceptress at the Department of Dermatology from the University of Mogi das Cruzes (UMC) -Mogi das Cruzes (SP), Brazil. 3 Preceptor of the Department of Dermatology at the Marcílio Dias Naval Hospital -Rio de Janeiro (RJ), Brazil.…”

mentioning

confidence: 99%

Líquen plano hipertrófico disseminado: relevante resposta à acitretina

Jaime

Guaraldi

et al. 2011

An. Bras. Dermatol.

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Hyperthrofic lichen planus is considered a variant of lichen planus with marked epidermal hyperplasia in response to persistent itch. It is clinically, characterized by symmetric hyperkeratotic plaques, of purplish-grey color, often located in the pretibial region. Intense pruritus, refractoriness to conventional treatments and the possibility of association of the long-term injuries with squamous cell carcinoma requires an effective treatment. The first-line treatment is corticosteroids which can be applied either topically or systemically. Other therapeutic modalities proposed are: NB-UVB phototherapy or PUVA, immunosuppressive drugs and systemic retinoids, notably acitretin. We report a case with exuberant clinical presentation of hyperthrofic lichen planus with excellent response to acitretin after nine months of treatment. Keywords: Acitretin; Immunosuppressive drugs; Lichen planus; Prednisone Resumo: O líquen plano hipertrófico é uma variante do líquen plano, com pronunciada hiperplasia epidér-mica em resposta à coçadura persistente. Clinicamente, caracterizam-se por placas hiperceratósicas, simétri-cas, de coloração cinza-violácea, com predileção pela região pré-tibial. O prurido intenso, a refratariedade aos tratamentos convencionais e a possibilidade de associação de um carcinoma epidermoide às lesões de longa duração impõem um tratamento eficaz. Os corticoides são considerados o tratamento de primeira linha e podem ser aplicados topicamente ou empregados de forma sistêmica. Outras modalidades terapêu-ticas propostas são a fototerapia com UVB-NB ou PUVA, imunossupressores e retinoides sistêmicos, com destaque para a acitretina. Relatamos um caso com apresentação clínica exuberante e excelente resposta à acitretin, totalizando um seguimento de nove meses.

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A Novel Visual Clue for the Diagnosis of Hypertrophic Lichen Planus

Cited by 11 publications

References 2 publications

Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

Hypertrophic lichen planus on the face

Líquen plano hipertrófico disseminado: relevante resposta à acitretina

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