A Novel Synthetic Method To Obtain Highly Crystallizable Absorbable Copolyesters

Andjelić, Saša; Jamiolkowski, Dennis D.; Kelly, Brian M.; Newman, H. D.

doi:10.1021/ma035052y

Cited by 5 publications

(2 citation statements)

References 23 publications

(47 reference statements)

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“…In this section we will describe the “mixed initiators” phenomenon, discovered in our laboratory about a decade ago . If, during the course of polymerization of glycolide‐containing copolymers, monofunctional and difunctional initiators are mixed and added to a reactor in a specific molar ratio, a copolymer resin is formed which exhibits significantly faster crystallization kinetics.…”

Section: Case Study 2—novel Chemical Manipulation Methods: Mixed Initmentioning

confidence: 99%

Polymer crystallization rate challenges: The art of chemistry and processing

Andjelić

Scogna

2015

J of Applied Polymer Sci

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The intention of this study is to discuss scientific advances toward one very important challenge in the polymer processing industry: How does one increase the crystallization rate of slow-to-crystallize polymeric materials, thereby facilitating processing and enabling peak product performance? In the medical device field, where both government-controlled regulatory entities and medical professionals closely scrutinize the biocompatibility of added crystallization rate enhancers, achieving these twin goals has always been challenging. Herein, we present a review of various chemical and physical approaches used to tune the crystallization rate of semicrystalline polymers, with a strong emphasis on two novel approaches recently discovered and developed in our laboratories.

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Section: Case Study 2—novel Chemical Manipulation Methods: Mixed Initmentioning

confidence: 99%

Polymer crystallization rate challenges: The art of chemistry and processing

Andjelić

Scogna

2015

J of Applied Polymer Sci

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“…Various p ‐dioxanone‐containing copolyesters, including poly( p ‐dioxanone‐ co ‐ε‐caprolactone), poly ( p ‐dioxanone‐ co ‐glycolide), poly( p ‐dioxanone‐ co ‐lactide), and poly( p ‐dioxanone‐ co ‐alkylene oxide), have been synthesized and proposed as alternative bioresorbable materials 15–24. However, little is known about these p ‐dioxanone copolymers because most of the information about them is in patents and therefore not easily accessible.…”

Section: Introductionmentioning

confidence: 99%

Sequence analysis of glycolide and p‐dioxanone copolymers

Rodríguez‐Galán

Franco

Puiggalı́

2009

J. Polym. Sci. A Polym. Chem.

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Low and medium molecular weight copolymers constituted by glycolide and p-dioxanone units have been synthesized by a ring-opening polymerization. The p-dioxanone monomer was obtained from (2-hydroxyethoxy)acetate or by thermal depolymerization of poly(p-dioxanone). 1 H and 13 C NMR spectra were highly sensitive to the chemical sequences, which were effectively assigned by considering the data from samples with different compositions, and the acquisition of heteronuclear 1 H and 13 C NMR-correlated spectra. End groups were also identified, allowing methylene protons of sequences involving up to two glycolide units to be distinguished. These data seem basic to analyze degradation products or the influence of thermal treatments in chain microstructure. Glycolide/p-dioxanone copolymers are an interesting system because changes on chemical sequences can easily occur due to a depolymerization reaction that eliminates p-dioxanone residues. Furthermore, depending on the polymerization conditions, the occurrence of transesterification reactions may be highly significant. These reactions have a great impact in properties such as the melting temperature and can be easily quantified by NMR spectroscopy because of the occurrence of a new chemical sequence.

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Crystallization behavior of poly(p‐dioxanone)‐PU/montmorillonite nanocomposites prepared by chain‐extending reaction

Zhang¹,

Niu²,

Huang³

et al. 2012

J of Applied Polymer Sci

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Organo‐modified montmorillonites and poly(p‐dioxanone) (PPDO) diol prepolymers were used to prepare Poly(p‐dioxanone)‐PU/organic montmorillonite (PPDO‐PU/OMMT) nanocomposites by chain‐extending reaction. The crystallization behavior and spherulitic morphology of PPDO‐PU/OMMT nanocomposites were investigated by WXRD, differential scanning calorimetry, and polarized optical microscopy. The results show that the regularity of the chain structure plays a dominant role during the crystallization process rather than that of OMMT content and its dispersion status in PPDO matrix. With similar molecular weight and same OMMT content, PPDO‐PU/OMMT nanocomposite, which derived from lower molecular weight PPDO prepolymer, exhibits lower crystallization rate, melting point, and crystallinity. The influence of the clay content on the crystallization behavior highly depends on its dispersing state. The nucleating effect of OMMT can be only observed at high loading percentage. For the nanocomposites with low clay loading percentage, the retarding effect of exfoliated platelets on the chain‐ordering into crystal lamellae became the key factor. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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A Novel Synthetic Method To Obtain Highly Crystallizable Absorbable Copolyesters

Cited by 5 publications

References 23 publications

Polymer crystallization rate challenges: The art of chemistry and processing

Polymer crystallization rate challenges: The art of chemistry and processing

Sequence analysis of glycolide and p‐dioxanone copolymers

Crystallization behavior of poly(p‐dioxanone)‐PU/montmorillonite nanocomposites prepared by chain‐extending reaction

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