2016
DOI: 10.1177/0363546516631954
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Abstract: ACL regeneration using a silk fiber-based scaffold with and without additional cell seeding may provide a new treatment option after joint injuries.

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Cited by 53 publications
(51 citation statements)
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References 45 publications
(55 reference statements)
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“…Previous groups have shown that compared to static culture, tensile loading of polymer scaffolds during culture encourages more cellular deposition of highly aligned collagen fibers similar to those observed in ligaments 56,57 . Additionally, nano-scale alterations such as modifying the nanofibers to have a crimp-like microarchitecture may encourage ECM deposition and cell differentiation 58,59 .…”
Section: Discussionmentioning
confidence: 67%
“…Previous groups have shown that compared to static culture, tensile loading of polymer scaffolds during culture encourages more cellular deposition of highly aligned collagen fibers similar to those observed in ligaments 56,57 . Additionally, nano-scale alterations such as modifying the nanofibers to have a crimp-like microarchitecture may encourage ECM deposition and cell differentiation 58,59 .…”
Section: Discussionmentioning
confidence: 67%
“…Augmentation devices, such as the ligament advanced replacement system (LARS), are also used and have shown a high success rate. Present generation synthetic materials for ligament regenerative engineering include, poly(l-lactic acid) (PLLA) [12,29], poly(glycolic acid) (PGA) [39], poly(lactic-co-glycolic acid) (PLGA) [29], polycapro lactone [40] and silk [41,42]. These materials are biodegradable, and thus allow for the regeneration of the ACL over time while providing initial stability of the knee joint.…”
Section: Present Approaches and Materials For Ligament Regenerative Engmentioning
confidence: 99%
“…In a study by Altman et al, silk fibers were braided in a 6-cord arrangement, which provide mechanical properties similar to the human ACL. Additionally, the slow rate of degradation of silk is a desirable quality and theoretically allows for the gradual transfer of mechanical load from the graft to the neoligament [41]. In the past, the drawback of the use of silk is the immune-eliciting sericin proteins, and that the degumming processes significantly alter the biomechanical properties of silk scaffolds.…”
Section: Present Approaches and Materials For Ligament Regenerative Engmentioning
confidence: 99%
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“…Electrospun SF scaffolds have been also used as photoactivated tendon wraps that improved the healing of damaged Achilles tendon in rabbits reducing the adhesions in surrounding tissues in an effective way . Recently, Teuschl et al . have obtained promising results using silk fiber‐based scaffolds in combination with autologous stem cells in the reconstruction of ACL after its resection, under in vivo conditions and using sheep as animal model.…”
Section: Introductionmentioning
confidence: 99%