2018
DOI: 10.1097/scs.0000000000004103 View full text |Buy / Rent full text
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Abstract: Severe traumatic injuries often result in critical size bone defects, which are unable to heal without treatment. Autologous grafting is the standard of care but requires additional surgeries for graft procurement. Amnion-derived multipotent progenitor cells release a secretome of biomolecules identified as integral to the process of bone regeneration and angiogenesis. This secretome is currently under development as a biotherapeutic. The efficacy of this secretome biotherapeutic was evaluated in vitro on the … Show more

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“…The secretome of MSCs is special, as a nondonor-specific and can be lyophilised, enabling more practical storage conditions [6]. These findings reinforce many researchers to look further into this molecule regarding their contents in the bone healing capability and to solve the existing problems with cell handling described earlier.…”
Section: Introductionmentioning
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“…The secretome of MSCs is special, as a nondonor-specific and can be lyophilised, enabling more practical storage conditions [6]. These findings reinforce many researchers to look further into this molecule regarding their contents in the bone healing capability and to solve the existing problems with cell handling described earlier.…”
Section: Introductionmentioning
“…We have observed that all included studies in this review revealed that the CM-MSC significantly enhances the bone regeneration compared to normal medium [6,7,9,[12][13][14][15][16][17]. The secretome was proven to be superior compared to MSC alone [14].…”
Section: Discussionmentioning
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“…This offers the ability to alter the responsiveness of immune cell populations, especially those with direct involvement in islet graft rejection, whilst proffering trophic support . Amnion‐derived stem cells (ASC) exhibit immune‐privilege, most likely via low‐level expression of surface MHC classes I and II, whilst the factors within the ASC secretome include a range of pro‐angiogenic, cell trophic, anti‐inflammatory and immunomodulatory cytokines . Despite these potential benefits in the context of clinical islet allo‐transplantation, the behaviour of human ASC populations for xenogenic immune events has not been widely characterized.…”
Section: Introductionmentioning