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Cited by 60 publications
(61 citation statements)
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“…PhcrTx1 (also π-PMTX-Pcf1a) was isolated from the sea anemone Phymanthus crucifer as an inhibitor of ASIC currents in rat DRG neurons with an IC 50 ~100 nM (Rodríguez et al, 2014). It also partially (less than 20%) inhibits voltage-gated K + currents in DRG neurons in the low micromolar range (IC 50 ~3.5 µM).…”
Section: Phcrtx1mentioning
confidence: 99%
See 1 more Smart Citation
“…PhcrTx1 (also π-PMTX-Pcf1a) was isolated from the sea anemone Phymanthus crucifer as an inhibitor of ASIC currents in rat DRG neurons with an IC 50 ~100 nM (Rodríguez et al, 2014). It also partially (less than 20%) inhibits voltage-gated K + currents in DRG neurons in the low micromolar range (IC 50 ~3.5 µM).…”
Section: Phcrtx1mentioning
confidence: 99%
“…23 predict a cluster of basic/aromatic residues to be the functional site for ASIC activity (Rodríguez et al, 2014).…”
Section: A C C E P T E D Accepted Manuscriptmentioning
confidence: 99%
“…PhcrTx1 is he firs compound charac erized from he sea anemone Phymanthus crucifer, and i consti u es a novel ASIC inhibi or PhcrTx1 represen s he firs member of a new s ruc ural group of sea anemones oxins acting on ASIC [58]. These oxins have been ins rumen al o s udy he s ruc ure, properties, functional expression in above-mentioned physiopa hological s a es.…”
Section: Pharmacological Agents Availablementioning
confidence: 99%
“…In the past, therapeutic peptides have been found in a variety of unexpected animal and plant sources ranging from venom of cone snails (Han et al 2008), spiders (Saez et al 2010;Gui et al 2014) to sea anemones (Rodríguez et al 2014). Genetic or recombinant libraries and chemical libraries (Meloen et al 2004) have also been the source of therapeutic peptides and synthetic combinatorial libraries have been used to identify bioactive peptides (Falciani et al 2005).…”
Section: Introductionmentioning
confidence: 99%