A novel Rickettsia infecting Amblyomma dubitatum ticks in Brazil

Almeida, Arlindo; Cunha, Lucas Maciel; Bello, Ana Cristina Passos de Paiva; Cunha, Arildo Pinto da; Domingues, Luísa N.; Leite, Romário Cerqueira; Labruna, Marcelo Bahia

doi:10.1016/j.ttbdis.2011.08.003

Cited by 29 publications

(13 citation statements)

References 23 publications

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“…is, to our knowledge, the first report of these host-tick relationships. This tick species (A. dubitatum = A. cooperi) [25] has been shown to harbor R. bellii, a species with unknown pathogenicity, and at least two other undefined Rickettsia species [26][27][28]. At the same time, it is a tick species with strong association in all parasitic stages with capybaras (Hydrochoerus hydrochaeris) [29].…”

Section: Discussionmentioning

confidence: 99%

Serologic evidence of the exposure of small mammals to spotted-fever Rickettsia and Rickettsia bellii in Minas Gerais, Brazil

Coelho

Limongi

Lemos

et al. 2016

J Infect Dev Ctries

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Introduction: Sources of pathogenic Rickettsia in wildlife are largely unknown in Brazil. In this work, potential tick vectors and seroreactivity of small mammals against four spotted-fever group Rickettsia (R. rickettsii, R. parkeri, R. amblyommii and R. rhipicephali) and Rickettsia bellii from peri-urban areas of Uberlândia, a major town in Brazil, are described for the first time. Methodology: Small mammals were captured and blood samples collected. Ticks were collected from the surface of the host and the environment and posteriorly identified. Reactivity of small mammal sera to Rickettsia was tested by indirect immunofluorescence assay (IFA) using crude antigens from five Brazilian Rickettsia isolates. Results: Information was obtained from 416 small mammals (48 Marsupialia and 368 Rodentia). Forty-eight animals were parasitized and two tick species, Ixodes loricatus and Amblyomma dubitatum, were found on several host species, with a few tick-host relationships described for the first time. From the 416 tested sera, 70 reacted to at least one Rickettsia antigen (prevalence of 16.8%) and from these, 19 (27.1%) reacted to two or more antigens. Seroprevalence was higher for marsupials (39.6%) than for rodents (13.8%). Marsupial and Rhipidomys spp. sera reacted mainly (highest seroprevalence and titers) to R. bellii, and that of Necromys lasiurus mainly to R. rickettsii. Conclusions: Although the serologic assays poorly discriminate between closely related spotted-fever group Rickettsia, the observed small mammal seroreactivity suggests the circulation of Rickettsia in the peri-urban area of Uberlândia, albeit at low levels.

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Section: Discussionmentioning

confidence: 99%

Serologic evidence of the exposure of small mammals to spotted-fever Rickettsia and Rickettsia bellii in Minas Gerais, Brazil

Coelho

Limongi

Lemos

et al. 2016

J Infect Dev Ctries

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“…The Pampulha strain, recently reported in A. dubitatum ticks in Brazil (201)(202)(203), and the Colombianensi strain, reported in Amblyomma dissimile and Rhipicephalus (Boophilus) microplus ticks in Colombia (204), are two distinct strains that are closely related to the Old World species Rickettsia tamurae and Rickettsia monacensis. In Brazil, only a few populations of A. dubitatum have been found to be infected by the Pampulha strain; however, infection rates are usually very high among the infected populations (203).…”

Section: South Americamentioning

confidence: 99%

Update on Tick-Borne Rickettsioses around the World: a Geographic Approach

et al. 2013

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SUMMARY Tick-borne rickettsioses are caused by obligate intracellular bacteria belonging to the spotted fever group of the genus Rickettsia . These zoonoses are among the oldest known vector-borne diseases. However, in the past 25 years, the scope and importance of the recognized tick-associated rickettsial pathogens have increased dramatically, making this complex of diseases an ideal paradigm for the understanding of emerging and reemerging infections. Several species of tick-borne rickettsiae that were considered nonpathogenic for decades are now associated with human infections, and novel Rickettsia species of undetermined pathogenicity continue to be detected in or isolated from ticks around the world. This remarkable expansion of information has been driven largely by the use of molecular techniques that have facilitated the identification of novel and previously recognized rickettsiae in ticks. New approaches, such as swabbing of eschars to obtain material to be tested by PCR, have emerged in recent years and have played a role in describing emerging tick-borne rickettsioses. Here, we present the current knowledge on tick-borne rickettsiae and rickettsioses using a geographic approach toward the epidemiology of these diseases.

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“…Atlantic rain forest Amblyomma ovale Rhipicephalus sanguineus Brazil [ 156 ] Unnamed [ 157 ] Rickettsia sp. strain Pampulha Amblyomma dubitatum Brazil [ 158 ] – – Rickettsia sp. strain colombianensi Amblyomma dissimile Colombia [ 159 ] – – Rickettsia sp.- novel isolate Ixodes ricinus Czech Republic [ 160 ] – – Rickettsia sp.…”

Section: New Rickettsiaementioning

confidence: 99%

Neglected aspects of tick-borne rickettsioses

et al. 2018

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Rickettsioses are among the oldest known infectious diseases. In spite of this, and of the extensive research carried out, many aspects of the biology and epidemiology of tick-borne rickettsiae are far from being completely understood. Their association with arthropod vectors, the importance of vertebrates as reservoirs, the rarity of clinical signs in animals, or the interactions of pathogenic species with rickettsial endosymbionts and with the host intracellular environment, are only some examples. Moreover, new rickettsiae are continuously being discovered. In this review, we focus on the ‘neglected’ aspects of tick-borne rickettsioses and on the gaps in knowledge, which could help to explain why these infections are still emerging and re-emerging threats worldwide.

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A novel Rickettsia infecting Amblyomma dubitatum ticks in Brazil

Cited by 29 publications

References 23 publications

Serologic evidence of the exposure of small mammals to spotted-fever Rickettsia and Rickettsia bellii in Minas Gerais, Brazil

Serologic evidence of the exposure of small mammals to spotted-fever Rickettsia and Rickettsia bellii in Minas Gerais, Brazil

Update on Tick-Borne Rickettsioses around the World: a Geographic Approach

Neglected aspects of tick-borne rickettsioses

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