A novel regulatory role of RGS4 in STAT5B activation, neurite outgrowth and neuronal differentiation

Pallaki, Paschalina; Georganta, Eirini-Maria; Serafimidis, Ioannis; Παπακωνσταντίνου, Μαρία-Παγώνα; Papanikolaou, Vassilis; Koutloglou, Sofia; Papadimitriou, Elsa; Agalou, Adamantia; Tserga, Aggeliki; Simeonof, Alexandra; Thomaidou, Dimitra; Gaitanou, Maria; Georgoussi, Zafiroula

doi:10.1016/j.neuropharm.2017.02.012

Cited by 21 publications

(16 citation statements)

References 60 publications

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“…These cascades include MAPKs and other signalling cascades of transcriptional factors, such as the Pax6-Ngn2-Tbr2-NeuroD1-Tbr1 and Prox1-Notch1 signalling pathways 17 . More recently, it was discovered that the regulator of G protein signalling 4 (RGS4) could regulate STAT5B-directed responses, which in turn modulate opioid-induced neurite outgrowth and neuronal differentiation 45 . These signalling cascades, along with biased agonism (the ligand-dependent functional selectivity of a receptor for certain pathways), represent common mechanisms underlying opioid effects on neurogenesis.…”

Section: Opioid Effects On Neurogenesismentioning

confidence: 99%

Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect

Kibaly

Cahill

et al. 2018

Nat Rev Neurosci

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Mortality due to opioid use has grown to the point where, for the first time in history, opioid-related deaths exceed those caused by car accidents in many states in the United States. Changes in the prescribing of opioids for pain and the illicit use of fentanyl (and derivatives) have contributed to the current epidemic. Less known is the impact of opioids on hippocampal neurogenesis, the functional manipulation of which may improve the deleterious effects of opioid use. We provide new insights into how the dysregulation of neurogenesis by opioids can modify learning and affect, mood and emotions, processes that have been well accepted to motivate addictive behaviours.

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Section: Opioid Effects On Neurogenesismentioning

confidence: 99%

Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect

Kibaly

Cahill

et al. 2018

Nat Rev Neurosci

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“…A similar reduction in the levels of STAT3 was observed in the VPA sets of our cultures for both the cell lines (Figure b). STAT5b are known to promote the formation of neurite extension and the maturation of neurons (Pallaki et al, ). A comparable enhancement in the levels of STAT5b was observed when VPA was added in both the cell lines, indicating its supportive role in the development towards mature neurons (Figure c).…”

Section: Resultsmentioning

confidence: 99%

Improved neural differentiation of normal and abnormal induced pluripotent stem cell lines in the presence of valproic acid

Fernandes

Vinnakota

Kumar

et al. 2019

J Tissue Eng Regen Med

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During the generation of induced pluripotent stem cell (iPSC) lines from cord blood CD34+ cells, a line having complete trisomy of Chromosome 1 and deletion of q23 to qTer of Chromosome 11 was accidentally developed in our lab. The abnormality was consistently detected even at higher passages. These chromosomal anomalies are known to manifest neurological developmental defects. In order to examine if such defects occur during in vitro differentiation of the cell line, we set up a protocol for neural differentiation. Valproic acid (VPA) was earlier reported by us to enhance neural differentiation of placental mesenchymal stem cells. Here, we induced normal and abnormal iPSC lines to neural lineage with/without VPA. Neural differentiation was observed in all four sets, but for both the iPSCs lines, VPA sets performed better. The characteristics tested were morphology, neural filament length, detection of neural markers, and electrophysiology. In summary, the karyotypically abnormal line exhibited efficient neural differentiation. This iPSC line may serve as a useful tool to study abnormalities associated with trisomy 1 and deletion of q23 to qTer of Chromosome 11.

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“…In this data analysis, we found that this gene is downregulated in the early stage of PFC development and its expression gradually increases with aging. The gene RGS4 has been shown to be involved in neuron differentiation and neurite growth (Pallaki et al, 2017). An animal test by Huang et al (Huang et al, 2018) showed that RGS4 deficiency in the prefrontal cortex may be related to schizophrenia-related behaviors.…”

Section: Hub Genes At Different Stages Reflect the Development Of Difmentioning

confidence: 99%

Time-Varying Gene Network Analysis of Human Prefrontal Cortex Development

Fang

et al. 2020

Front. Genet.

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The prefrontal cortex (PFC) constitutes a large part of the human central nervous system and is essential for the normal social affection and executive function of humans and other primates. Despite ongoing research in this region, the development of interactions between PFC genes over the lifespan is still unknown. To investigate the conversion of PFC gene interaction networks and further identify hub genes, we obtained time-series gene expression data of human PFC tissues from the Gene Expression Omnibus (GEO) database. A statistical model, loggle, was used to construct time-varying networks and several common network attributes were used to explore the development of PFC gene networks with age. Network similarity analysis showed that the development of human PFC is divided into three stages, namely, fast development period, deceleration to stationary period, and recession period. We identified some genes related to PFC development at these different stages, including genes involved in neuronal differentiation or synapse formation, genes involved in nerve impulse transmission, and genes involved in the development of myelin around neurons. Some of these genes are consistent with findings in previous reports. At the same time, we explored the development of several known KEGG pathways in PFC and corresponding hub genes. This study clarified the development trajectory of the interaction between PFC genes, and proposed a set of candidate genes related to PFC development, which helps further study of human brain development at the genomic level supplemental to regular anatomical analyses. The analytical process used in this study, involving the loggle model, similarity analysis, and central analysis, provides a comprehensive strategy to gain novel insights into the evolution and development of brain networks in other organisms.

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A novel regulatory role of RGS4 in STAT5B activation, neurite outgrowth and neuronal differentiation

Cited by 21 publications

References 60 publications

Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect

Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect

Improved neural differentiation of normal and abnormal induced pluripotent stem cell lines in the presence of valproic acid

Time-Varying Gene Network Analysis of Human Prefrontal Cortex Development

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