A novel porphyrin–polypyridyl ruthenium(II) hybrid. Synthesis, characterization and photoinduced DNA cleavage activity

Abstract

A novel porphyrin-polypyridyl ruthenium(II) hybrid compound, [C 4 -TPP-(ip)Ru(phen) 2 ](ClO 4 ) 2 (TPP = 5,10,15, ip = imidazo[4,[1,10]phenanthroline and phen = 1,10-Phenanthroline), in which a polypyridyl ruthenium(II) moiety is linked to a porphyrin moiety by a butyl chain, has been synthesized by the reaction of (C 4 ip)TPP with cis-Ru(phen) 2 Cl 2 in glacial acetic acid under an Ar atmosphere and characterized by elemental analysis, i.r., 1 H-n.m.r., u.v.-vis., ESI-MS and electrochemistry. Its photoinduced DNA cleavage activity was investigated preliminarily. It has been found that the hybrid compound promoted photocleavage of plasmid pBR 322 DNA upon irradiation. Singlet oxygen ( 1 O 2 ) is suggested to be the reactive species responsible for the cleavage.

Two‐Dimensional Self‐Assembly of a Porphyrin–Polypyridyl Ruthenium(II) Hybrid on HOPG Surface through Metal–Ligand Interactions

“…This work demonstrates that introducing a metal-ligand in the porphyrin-polypyridyl compound is a useful strategy to obtain novel surface assemblies. [25][26][27] 2.2. Spectroscopic Characterization Figure 1 shows the electronic absorption spectrum and emission spectra of (C 8 ip)TPPC in chloroform .…”