volume 6, issue 55, P50053-50060 2016
DOI: 10.1039/c6ra08935f
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Abstract: A macrocyclic polyamine lipid bearing both fluorescent naphthalimide and targeting cholic acid moieties, 1, was designed and synthesized as a novel non-viral gene vector. Plasmid DNA was completely condensed at 10 mM of 1 (N/P ¼ 3.6) in 5 minutes at 37 C. The process of DNA uptake process by 1 in a single cell was clearly investigated through time-dependent fluorescence microscopy assay. Flow cytometry experiments of liposome 1 clearly proved its targeting activity toward HepG2 cells. Luciferase gene expressi…

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