2016
DOI: 10.1038/srep20307
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) sepsis is a life-threatening medical condition thatMethicillin-resistant staphylococcus aureus (MRSA) sepsis is a blood infection with staphylococcus bacteria that are resistant to treatment with beta-lactam antibiotics. MRSA sepsis is a life-threatening medical condition that is caused by an overpowering immune response to MRSA infection and leads to systemic inflammation. Early diagnosis and rapid treatment increase the chances of patient survival, although … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
12
0

Year Published

2016
2016
2023
2023

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 18 publications
(12 citation statements)
references
References 51 publications
0
12
0
Order By: Relevance
“…S. aureus , the main pathogen of G + bacteria, is one of the most prevalent causes of sepsis with high mortality in U.S. hospitals 1 7 8 . Along with the emergence of MRSA, patients with sepsis face an increased risk of death 10 11 . A number of therapeutic strategies were put forward to aim at treating sepsis induced by S. aureus or MRSA targeting either the pathogens or the host’s response.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…S. aureus , the main pathogen of G + bacteria, is one of the most prevalent causes of sepsis with high mortality in U.S. hospitals 1 7 8 . Along with the emergence of MRSA, patients with sepsis face an increased risk of death 10 11 . A number of therapeutic strategies were put forward to aim at treating sepsis induced by S. aureus or MRSA targeting either the pathogens or the host’s response.…”
Section: Discussionmentioning
confidence: 99%
“…Although all G − bacteria had decreased mortality hazards, methicillin-resistant S. aureus (MRSA) had the highest mortality hazard of 1.38 (1.33–1.44) of G + organisms 9 . Even though early use of antibiotics increased the survival chances of patients with sepsis, the patients still face a higher risk of death due to uncontrolled inflammation and drug resistance 10 11 .…”
mentioning
confidence: 99%
“…Most of the multidrug-resistant MRSA strains have the capability of biofilm formation which is an important virulence determinant 19 as well as a barrier against the treatment of infections 20 . Bacterial biofilm is a structured aggregation of bacterial cells surrounded by a self-produced matrix layer and adherent to the host surface 21 .…”
Section: Discussionmentioning
confidence: 99%
“…In particular, a NO-releasing derivative of dexamethasone, ND8008, was found to be more effective than dexamethasone in reducing the inflammatory response in LPS-stimulated mouse peritoneal macrophages and in an in vivo model of methicillin-resistant Staphylococcus aureus (MRSA) blood infection (188). …”
Section: Endothelial Response To Gcs In Sepsismentioning
confidence: 99%