A novel murine model of cyclical cutaneous ischemia-reperfusion injury

Reid, Russell R.; Sull, Alan C; Mogford, Jon E.; Roy, Nakshatra K.; Mustoe, Thomas A.

doi:10.1016/s0022-4804(03)00227-0

Cited by 57 publications

(45 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Magnets have been used for experimental models of pressure ulcers (Peirce et al, 2000;Reid et al, 2004;ener et al, 2006;Saito et al, 2008). In these, a magnet or steel plate was implanted in the subcutaneous connective tissue and compressed by applying another magnet to the skin.…”

Section: Magnet Compression As a Model Of Compression Ulcersmentioning

confidence: 99%

“…A n i n v e r s e r e l a t i o n s h i p e x i s t s b e t w e e n t h e s e parameters required to produce a pressure ulcer (Kosiak, 1959;Daniel et al, 1981;Linder-Ganz et al, 2006). Another plausible cause of pressure u l c e r s i s i s c h e m i a -r e p e r f u s i o n i n j u r y ( P e i r c e et al., 2000;Reid et al, 2004;Cordeiro et al, 2005Cordeiro et al, , ener et al, 2006. These two factors, i.e., prolonged ischemia and ischemia-reperfusion, are generally considered the most important causes for the development of pressure ulcers.…”

Section: Introductionmentioning

confidence: 99%

“…This required the animals to be anesthetized during experiments to sedate and immobilize them (Kosiak, 1959;Daniel et al, 1981;Bosboom et al, 2001Bosboom et al, , 2003Gefen, 2004, Kawai et al, 2005;LinderGanz et al, 2006;Stekelenburg et al, 2007). On the other hand, Peirce et al (2000), Reid et al (2004Reid et al ( ), ener et al (2006 and Sisco et al (2007) compressed skin using magnets in waking conditions. They implanted a magnet or a steel plate in the subcutaneous connective tissue of the back and caused compression by applying a magnet to the skin.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison between a weight compression and a magnet compression for experimental pressure ulcers in the rat. Histological studies and effects of anesthesia

Hashimoto

Kurose

Kawamata

2008

Archives of Histology and Cytology

View full text Add to dashboard Cite

and low in the skin. The compression with anesthesia produced significantly milder injuries than those under anesthesia. These findings indicate that the difference in the extent of injuries between the weight compression and maget compression models are clearly attributable to the pentobarbital anesthesia induced during the compression. Results therefore show that experimental pressure ulcers should be examined in a waking condition and that magnet compression is a useful model for studying the pathogenesis of pressure ulcers.

show abstract

Section: Magnet Compression As a Model Of Compression Ulcersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison between a weight compression and a magnet compression for experimental pressure ulcers in the rat. Histological studies and effects of anesthesia

Hashimoto

Kurose

Kawamata

2008

Archives of Histology and Cytology

View full text Add to dashboard Cite

show abstract

“…To produce pressure ulcers, the use of magnets has been reported in the literature (Peirce et al, 2000;Reid et al, 2004;Şener et al, 2006;Saito et al, 2008;Wassermann et al, 2009). However, the pressure in previous studies was either not measured or was not as accurate as in our experiment.…”

Section: Discussionmentioning

confidence: 54%

“…P e i r c e e t a l . (2000), Reid et al (2004) and Wassermann et al (2009) used magnets for models of pressure ulcers. They implanted a magnet or a steel plate into the subcutaneous connective tissue of the back or under a m u s c l e ( W a s s e r m a n n e t a l .…”

Section: Methodsmentioning

confidence: 99%

<b>Development and repair of experimental pressure ulcers in the rat abdominal wall induced by repeated compression using magnets</b>

Kawamata

Kurose

Honkawa

et al. 2011

Archives of Histology and Cytology

View full text Add to dashboard Cite

of the skin proceeded to full-thickness necrosis and/or discoloration throughout or in part of the compressed area. Necrotic skin was replaced by black/brown eschar, accompanying exudation, and significant tissue hardening. The injuries considerably contracted a few days after completing the series of compressions. The eschar further decreased gradually in size and usually became detached with time, after which a skin ulcer formed. A small number of rats showed only erosion and/or severe redness of the skin, damage which was reversible to heal without eschar formation. Generally, skin injuries seemed most severe a few days after 5 compressions and essentially healed over the subsequent 20 days. This model should prove useful for developing preventive measures and treating pressure ulcers. IntroductionP r e s s u r e u l c e r s c o n s t i t u t e a m a j o r p r o b l e m f o r persons who are unable or find it difficult to change the position of their bodies. Studying the pathogenesis and repair process of pressure ulcers is of great clinical importance to prevent and treat pressure ulcers. However, the mechanisms of development a n d p r o g r e s s i o n o f p r e s s u r e u l c e r s a r e n o t f u l l y understood because numerous factors are involved in their production (Stekelenburg et al., 2005), including the magnitude of pressure, exposure time, friction, shear forces Gefen, 2004, 2007), and temperature (Kokate et al., 1995 Summary. A better understanding of pressure ulcers requires animal models under precise experimental conditions. We here report on an improved and clinically more relevant model of pressure ulcers. Rats underwent implantation of a gold-plated magnet (25 20 2 mm) into their peritoneal cavities under anesthesia. At either 3 or 4 days postoperatively, the rat abdominal wall was repeatedly compressed at 100 mmHg (13.3 kPa) for 4 h daily for 5 consecutive days by applying another magnet to the skin while animals were conscious. The rats were reared without further treatment and the abdominal skin was photographed daily. Specimens were removed at appropriate intervals for histological examination. Edema and mild redness of the skin appeared at 1 day after the first compression. After a few repetitions of compression, edema and redness of the skin were enhanced. Subsequently, in the majority of rats, redness

show abstract

The lactate conundrum in wound healing: Clinical and experimental findings indicate the requirement for a rapid point‐of‐care diagnostic

Britland

Ross-Smith

Jamil

et al. 2012

Biotechnology Progress

View full text Add to dashboard Cite

show abstract

A novel murine model of cyclical cutaneous ischemia-reperfusion injury

Cited by 57 publications

References 17 publications

Comparison between a weight compression and a magnet compression for experimental pressure ulcers in the rat. Histological studies and effects of anesthesia

Comparison between a weight compression and a magnet compression for experimental pressure ulcers in the rat. Histological studies and effects of anesthesia

<b>Development and repair of experimental pressure ulcers in the rat abdominal wall induced by repeated compression using magnets</b>

The lactate conundrum in wound healing: Clinical and experimental findings indicate the requirement for a rapid point‐of‐care diagnostic

Contact Info

Product

Resources

About