A novel mouse model for vulnerability to alcohol dependence induced by early-life adversity

Okhuarobo, Agbonlahor; Bolton, Jessica L.; Igbe, Ighodaro; Zorrilla, Eric P.; Baram, Tallie Z.; Contet, Candice

doi:10.1016/j.ynstr.2020.100269

Cited by 30 publications

(45 citation statements)

References 77 publications

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“…Far fewer studies have examined deficits in self‐care or motivational behavior due to resource scarcity. In agreement with our own findings in rats, a recent report described no effect of LBN rearing in mice on grooming behavior in the splash test (Okhuarobo et al., 2020). However, as with the “core features” assessed in the previously described tests, apathy or lack of motivation is not specific to depression and can be considered across cognitive, emotional, and behavioral contexts (Starkstein & Leentjens, 2008).…”

Section: Discussionsupporting

confidence: 93%

Neonatal resource scarcity alters maternal care and impacts offspring core temperature and growth in rats

Shupe

Clinton

2021

Developmental Psychobiology

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Stressful experiences during childhood, including poverty and inconsistent parental care, can enhance vulnerability for worsened physical and mental health outcomes in adulthood. Using Sprague Dawley rats, the present study explored the impact of limited resource availability on maternal behavior and physiological and emotional behavior outcomes in the offspring. Early life adversity was induced by incorporating aspects of the limited bedding and nesting and scarcity models, wherein limited resource availability has previously been shown to provoke unpredictable or adverse maternal care respectively. In our hands, neonatal limited bedding (NLB) stress during postnatal days (P)2–9 altered maternal care, augmenting pup‐directed behaviors and reducing self‐directed behaviors, and modestly increased the frequency of transitions between discrete behaviors across consecutive timed observations. NLB‐exposed pups had lower core body temperatures immediately following the stressful manipulation and exhibited decreased body weight gain across development. However, NLB exposure did not impact adult offspring's social or emotional behavior outcomes in the three‐chamber social interaction, novelty‐suppressed feeding, splash, or forced swim tests. These findings add to the literature demonstrating that early life adversity impacts maternal care in rodents and can disrupt certain metabolic and thermoregulatory outcomes in the offspring.

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Section: Discussionsupporting

confidence: 93%

Neonatal resource scarcity alters maternal care and impacts offspring core temperature and growth in rats

Shupe

Clinton

2021

Developmental Psychobiology

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“…pPVT inhibition prevents cocaine cue-induced relapse-like behaviors (Matzeu et al, 2015), and inhibition of anterior and mid-PVT projections to the NAc prevents opioid-primed relapse and blocks preference for a morphine-paired chamber in a morphine-conditioned place preference assay (Keyes et al, 2020). Similar to the influence of ELA on alcohol dependence, which includes increased intermittent access consumption (Daoura et al, 2011), accelerated intake escalation, and exacerbated affective dysfunction during withdrawal (Okhuarobo et al, 2020), stimulation of the aPVT with orexin or substance P increases intermittent-access consumption of alcohol (Barson et al, 2015).…”

Section: Diverse Consequences Of Early-life Experiences On the Brain And Behaviormentioning

confidence: 99%

The Paraventricular Thalamus: A Potential Sensor and Integrator of Emotionally Salient Early-Life Experiences

Kooiker

Birnie

Baram

2021

Front. Behav. Neurosci.

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Early-life experiences influence a broad spectrum of behaviors throughout the lifespan that contribute to resilience or vulnerability to mental health disorders. Yet, how emotionally salient experiences early in life are encoded, stored, and processed and the mechanisms by which they influence future behaviors remain poorly understood. The paraventricular nucleus of the thalamus (PVT) is a key structure in modulating positive and negative experiences and behaviors in adults. However, little is known of the PVT’s role in encoding and integrating emotionally salient experiences that occur during neonatal, infancy, and childhood periods. In this review, we (1) describe the functions and connections of the PVT and its regulation of behavior, (2) introduce novel technical approaches to elucidating the role of the PVT in mediating enduring changes in adult behaviors resulting from early-life experiences, and (3) conclude that PVT neurons of neonatal rodents are engaged by both positive and negative emotionally salient experiences, and their activation may enduringly govern future behavior-modulating PVT activity during emotionally salient contexts.

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“…However, inconsistent findings have also been reported. Maternal deprivation reared male and female Wistar rats do not show increased ethanol intake until after two-wk of withdrawal and additional stress in adulthood ( 121 ), and LBN rearing decreases ethanol consumption during acquisition in male but not female C57BL/6J mice ( 122 ). In this same study, ethanol consumption levels eventually matched between groups, suggesting that ELS reduced the rewarding properties of ethanol only during early exposure and did not cause a long-lasting deficit in preference.…”

Section: Impact Of Early Life Stress On Motivated Behavior and Reward Circuit Activity From Non-human Animal Modelsmentioning

confidence: 99%

Impact of Early Life Stress on Reward Circuit Function and Regulation

et al. 2021

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Early life stress – including experience of child maltreatment, neglect, separation from or loss of a parent, and other forms of adversity – increases lifetime risk of mood, anxiety, and substance use disorders. A major component of this risk may be early life stress-induced alterations in motivation and reward processing, mediated by changes in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Here, we review evidence of the impact of early life stress on reward circuit structure and function from human and animal models, with a focus on the NAc. We then connect these results to emerging theoretical models about the indirect and direct impacts of early life stress on reward circuit development. Through this review and synthesis, we aim to highlight open research questions and suggest avenues of future study in service of basic science, as well as applied insights. Understanding how early life stress alters reward circuit development, function, and motivated behaviors is a critical first step toward developing the ability to predict, prevent, and treat stress-related psychopathology spanning mood, anxiety, and substance use disorders.

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A novel mouse model for vulnerability to alcohol dependence induced by early-life adversity

Cited by 30 publications

References 77 publications

Neonatal resource scarcity alters maternal care and impacts offspring core temperature and growth in rats

Neonatal resource scarcity alters maternal care and impacts offspring core temperature and growth in rats

The Paraventricular Thalamus: A Potential Sensor and Integrator of Emotionally Salient Early-Life Experiences

Impact of Early Life Stress on Reward Circuit Function and Regulation

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