A novel method to evaluate salivary flow rates of head and neck cancer patients after radiotherapy: a pilot study

Palma, Luiz Felipe; Gonnelli, Fernanda Aurora Stabile; Marcucci, Marcelo; Giordani, Adelmo José; Dias, Rodrigo; Segreto, Roberto Araújo; Segreto, Helena Regina Comodo

doi:10.1016/j.bjorl.2017.03.004

Cited by 11 publications

(8 citation statements)

References 19 publications

(41 reference statements)

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“…35 Indeed, our preliminary study 14 and others 12,36 have shown that the induction phase is a critical time for hematological cancer treatment with more impact on oral physiological parameters such as saliva, oral microbiota, and host cell interactions. Although some previous studies have also evaluated these response variables (USF and oral streptococci load), the results are crosssectional 11,13,18 or longitudinal of short-term periods (50 days for the endpoint), 9,22,37,38 which are not able to completely evaluate the impact of cancer therapy on different follow-up time-points.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 This cancer treatment can particularly induce some physicochemical changes in the saliva characteristics, such as the excretion flow rate, organic and inorganic composition, and immunological properties. 10,11 Salivary changes in children have consequently been associated with deteriorating oral health status during chemotherapy. 9,[12][13][14] However, some cross-sectional studies 15,16 have shown controversial results regarding chemotherapy's effect on the salivary flow rate because the saliva exams were performed in different early stages of cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

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Unstimulated salivary flow and oral streptococci in pediatric patients with hematological tumors: A longitudinal study

Araújo

Costa

Ribeiro

et al. 2021

Special Care in Dentistry

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Aims:To evaluate the unstimulated salivary flow (USF) and salivary colonization of total Streptococcus spp. (TS) and mutans-group (MS) in pediatric patients with hematological tumors. Correlations of salivary and microbiological changes with chemotherapy and patient-related factors were also verified. Methods and Results: Eligible children (n = 31) were evaluated before (control) and after (2, 5, and 10-weeks) the chemotherapy protocol was applied. Saliva samples were collected by the traditional spitting method to determine the USF (ml/min). Salivary TS and MS were determined by colony-forming units (CFU ) counts in a selective medium. The caries experience was evaluated by DMFT/dmft indexes. Data were submitted to Student's t-test, one-way ANOVA, and correlation tests (α = 0.05). The USF rate at baseline was 0.89 (±0.73) ml/min with up to 20% reduction during the follow-up and did not differ statistically during chemotherapy (p > .05). Chemotherapy did not modify the salivary TS load (p > .05), but induced a dysbiotic shift with higher MS counts (∼ 5 fold-increase) at 10-weeks (p < .05). There is a correlation of USF with age (r = .390) and SM load with caries experience (r s = −.540) at 5-weeks. Conclusion:Chemotherapy may promote a specific increase of mutans-group streptococci without changing the Streptococcus spp. load and unstimulated saliva flow. Correlation reinforced the need for further enlightenment about the chemotherapy mechanisms in the salivary and microbiological parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unstimulated salivary flow and oral streptococci in pediatric patients with hematological tumors: A longitudinal study

Araújo

Costa

Ribeiro

et al. 2021

Special Care in Dentistry

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“…Advanced cases, in contrast, commonly require chemotherapy and/or surgery. 1,2 The deleterious effects of radiation on bone tissue have been closely examined with the goal of elucidating the mechanisms leading to osteoradionecrosis, 3 but conclusive evidence is not yet available. Histomorphometric analysis of biopsies has proven to be a valuable laboratory method to evaluate bone quality, while clinical methods include digital radiography, ultrasonography, and computed tomography.…”

Section: Introductionmentioning

confidence: 99%

Impact of radiotherapy on mandibular bone: A retrospective study of digital panoramic radiographs

Palma

Tateno²,

Remondes³

et al. 2020

Imaging Sci Dent

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Purpose: The purpose of this study was to investigate the impact of radiotherapy on mandibular bone tissue in head and neck cancer patients through an analysis of pixel intensity and fractal dimension values on digital panoramic radiographs. Materials and Methods: Thirty patients with radiographic records from before and after 3-dimensional (3D) conformational radiotherapy were selected. A single examiner carried out digital analyses of pixel intensity values and fractal dimensions, with the areas of interest unilaterally located in the right angle medullary region of the mandible below the mandibular canal and posterior to the molar region. Results: Statistically significant decreases were observed in the mean pixel intensity (P = 0.0368) and fractal dimension (P = 0.0495) values after radiotherapy. Conclusion: The results suggest that 3D conformational radiotherapy for head and neck cancer negatively affected the trabecular microarchitecture and mandibular bone mass.

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“…A literatura afirma que a escolha do tratamento do CCP depende de sua localização e estádio (GALBIATTI et al, 2013;DEMIAN et al, 2014;VINES et al, 2017). A radioterapia é considerada a modalidade padrão para os cânceres em estádio inicial, nos casos mais avançados, é indicada a associação com cirurgia e/ou quimioterapia (PALMA et al, 2017 (GULLIFORD et al, 2012;XIAO et al, 2016;WEBER;O'BRIEN, 2016;HASHEMI et al, 2017;LIPSETT et al, 2017). Sawada et al (2012) KOMURCU, 2010;KWEKKEBOOM et al, 2012;FINNEGAN-JOHN et al, 2013;BAR-SELA et al, 2015).…”

Section: Qualidade De Vida Relacionada à Saúdeunclassified

“…Para a maioria dos cânceres de cabeça e pescoço em fase inicial, a radioterapia é considerada como a modalidade terapêutica padrão, seu principal objetivo é controlar a evolução do tumor com o menor dano possível aos tecidos e órgãos normais adjacentes (PALMA et al, 2017). O tratamento radioterápico apesar de apresentar a vantagem de preservar a estrutura dos tecidos, pode acarretar reações adversas que se manifestam na cavidade oral, entre elas estão a mucosite,…”

Section: Introductionunclassified

Relaxamento com visualização guiada: influência sobre a fadiga e a qualidade de vida relacionada à saúde de pacientes com câncer de cabeça e pescoço durante o tratamento radioterápico

Avelar¹

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DEDICATÓRIAS A DEUS, por me proporcionar a dádiva da vida e me fortalecer todos os dias nesta caminhada, às vezes difícil, porém, edificante. Ao meu filho Felipe, que é uma das maiores razões do meu viver, pelo qual tenho um amor incondicional, sem limites, sem mensuração, e que me dá forças todos os dias para eu ser uma pessoa cada vez melhor. Ao meu marido Alberto, que é meu amor, amigo, companheiro... A pessoa que eu posso contar todas as horas e que eu tenho profunda admiração e respeito. A minha avó Maria Olímpia, que sempre foi a pessoa em que me espelhei, meu grande exemplo de ser humano, e onde quer que ela esteja, sei que sempre esteve torcendo e orando por mim. Aos pacientes com câncer, em especial aos com câncer de cabeça e pescoço, que aceitaram participar deste estudo, compreendendo a importância da ciência para o aperfeiçoamento do cuidado. AGRADECIMENTOS À minha orientadora, Profa. Dra. Namie Okino Sawada que sempre esteve comigo em minha trajetória acadêmica, desde o primeiro ano de graduação, sempre confiando em meu trabalho, me estimulando e, sobretudo, me ensinando muito com todo seu conhecimento e experiência. É uma excelente profissional e pessoa, na qual tenho uma enorme admiração, respeito e carinho. À Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), pelo apoio financeiro fornecido para o desenvolvimento do projeto, por meio de Projeto Regular-Processo 2013/04649-1. Aos meus pais Márcio e Silvia, por estarem sempre ao meu lado e por compartilharem comigo de todos os momentos de minha vida. À minha família amada, que sempre foi e sempre será a base de tudo em minha vida, meu pilar de sustentação, minha fortaleza, principalmente meu filho Felipe, que é minha inspiração diária. Ao meu marido Alberto, especialmente, pelo carinho, companheirismo, e paciência que sempre teve comigo, sempre acreditando e me apoiando em todos os momentos.

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A novel method to evaluate salivary flow rates of head and neck cancer patients after radiotherapy: a pilot study

Abstract: This novel method seems to be suitable for patients submitted to radiotherapy.

Cited by 11 publications

References 19 publications

Unstimulated salivary flow and oral streptococci in pediatric patients with hematological tumors: A longitudinal study

Unstimulated salivary flow and oral streptococci in pediatric patients with hematological tumors: A longitudinal study

Impact of radiotherapy on mandibular bone: A retrospective study of digital panoramic radiographs

Relaxamento com visualização guiada: influência sobre a fadiga e a qualidade de vida relacionada à saúde de pacientes com câncer de cabeça e pescoço durante o tratamento radioterápico

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